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Impact of Compression Force on Mechanical, Textural, Release and Chewing Perception Properties of Compressible Medicated Chewing Gums

Medicated chewing gums (MCGs) represent a beneficial platform for realizing drugs intended for dental prophylaxis and treatment. The present study aimed to investigate the impact of compression force on the mechanical, textural, release, and chewing perception characteristics of compressible MCGs wi...

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Autores principales: Maslii, Yuliia, Kolisnyk, Tetiana, Ruban, Olena, Yevtifieieva, Olga, Gureyeva, Svitlana, Goy, Andriy, Kasparaviciene, Giedre, Kalveniene, Zenona, Bernatoniene, Jurga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621342/
https://www.ncbi.nlm.nih.gov/pubmed/34834223
http://dx.doi.org/10.3390/pharmaceutics13111808
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author Maslii, Yuliia
Kolisnyk, Tetiana
Ruban, Olena
Yevtifieieva, Olga
Gureyeva, Svitlana
Goy, Andriy
Kasparaviciene, Giedre
Kalveniene, Zenona
Bernatoniene, Jurga
author_facet Maslii, Yuliia
Kolisnyk, Tetiana
Ruban, Olena
Yevtifieieva, Olga
Gureyeva, Svitlana
Goy, Andriy
Kasparaviciene, Giedre
Kalveniene, Zenona
Bernatoniene, Jurga
author_sort Maslii, Yuliia
collection PubMed
description Medicated chewing gums (MCGs) represent a beneficial platform for realizing drugs intended for dental prophylaxis and treatment. The present study aimed to investigate the impact of compression force on the mechanical, textural, release, and chewing perception characteristics of compressible MCGs with the combination of lysozyme hydrochloride (LH) and ascorbic acid (AsA). Four batches of MCGs were obtained on a laboratory single-punch tablet machine applying different forces, i.e., 5, 7, 10, and 15 kN, and evaluated by their geometrical parameters, mechanical resistance, surface and internal structure characteristics, texture profile, release behavior, and perception attributes during mastication. It was found that increasing compression force slightly affected resistance to crushing and friability of MCGs, but resulted in surface smoothing and formation of a thicker layer with highly compacted particle arrangement. According to the texture analysis, increasing compression force led to harder and more adhesive gums, indicating possible difficulties in chewing and, therefore, impairment of their consumer properties. Lower compression forces were also found to be preferable in terms of better drug release from the obtained chewing gums. The volunteers’ assessment showed that an increase of compression force led to significantly raising the initial hardness and crumbliness as well as to decreasing the rate of the integral gum mass formation during mastication, which may negatively affect perceptive sensations when using MCGs. Based on the results obtained, the optimal compressing force was selected to be 7 kN, which allows obtaining MCGs with good organoleptic, mechanical, textural, and release properties.
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spelling pubmed-86213422021-11-27 Impact of Compression Force on Mechanical, Textural, Release and Chewing Perception Properties of Compressible Medicated Chewing Gums Maslii, Yuliia Kolisnyk, Tetiana Ruban, Olena Yevtifieieva, Olga Gureyeva, Svitlana Goy, Andriy Kasparaviciene, Giedre Kalveniene, Zenona Bernatoniene, Jurga Pharmaceutics Article Medicated chewing gums (MCGs) represent a beneficial platform for realizing drugs intended for dental prophylaxis and treatment. The present study aimed to investigate the impact of compression force on the mechanical, textural, release, and chewing perception characteristics of compressible MCGs with the combination of lysozyme hydrochloride (LH) and ascorbic acid (AsA). Four batches of MCGs were obtained on a laboratory single-punch tablet machine applying different forces, i.e., 5, 7, 10, and 15 kN, and evaluated by their geometrical parameters, mechanical resistance, surface and internal structure characteristics, texture profile, release behavior, and perception attributes during mastication. It was found that increasing compression force slightly affected resistance to crushing and friability of MCGs, but resulted in surface smoothing and formation of a thicker layer with highly compacted particle arrangement. According to the texture analysis, increasing compression force led to harder and more adhesive gums, indicating possible difficulties in chewing and, therefore, impairment of their consumer properties. Lower compression forces were also found to be preferable in terms of better drug release from the obtained chewing gums. The volunteers’ assessment showed that an increase of compression force led to significantly raising the initial hardness and crumbliness as well as to decreasing the rate of the integral gum mass formation during mastication, which may negatively affect perceptive sensations when using MCGs. Based on the results obtained, the optimal compressing force was selected to be 7 kN, which allows obtaining MCGs with good organoleptic, mechanical, textural, and release properties. MDPI 2021-10-29 /pmc/articles/PMC8621342/ /pubmed/34834223 http://dx.doi.org/10.3390/pharmaceutics13111808 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maslii, Yuliia
Kolisnyk, Tetiana
Ruban, Olena
Yevtifieieva, Olga
Gureyeva, Svitlana
Goy, Andriy
Kasparaviciene, Giedre
Kalveniene, Zenona
Bernatoniene, Jurga
Impact of Compression Force on Mechanical, Textural, Release and Chewing Perception Properties of Compressible Medicated Chewing Gums
title Impact of Compression Force on Mechanical, Textural, Release and Chewing Perception Properties of Compressible Medicated Chewing Gums
title_full Impact of Compression Force on Mechanical, Textural, Release and Chewing Perception Properties of Compressible Medicated Chewing Gums
title_fullStr Impact of Compression Force on Mechanical, Textural, Release and Chewing Perception Properties of Compressible Medicated Chewing Gums
title_full_unstemmed Impact of Compression Force on Mechanical, Textural, Release and Chewing Perception Properties of Compressible Medicated Chewing Gums
title_short Impact of Compression Force on Mechanical, Textural, Release and Chewing Perception Properties of Compressible Medicated Chewing Gums
title_sort impact of compression force on mechanical, textural, release and chewing perception properties of compressible medicated chewing gums
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621342/
https://www.ncbi.nlm.nih.gov/pubmed/34834223
http://dx.doi.org/10.3390/pharmaceutics13111808
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