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Polymorphism of Alpha-Synuclein Amyloid Fibrils Depends on Ionic Strength and Protein Concentration

Protein aggregate formation is linked with multiple amyloidoses, including Alzheimer‘s and Parkinson‘s diseases. Currently, the understanding of such fibrillar structure formation and propagation is still not sufficient, the outcome of which is a lack of potent, anti-amyloid drugs. The environmental...

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Detalles Bibliográficos
Autores principales: Ziaunys, Mantas, Sakalauskas, Andrius, Mikalauskaite, Kamile, Smirnovas, Vytautas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621411/
https://www.ncbi.nlm.nih.gov/pubmed/34830264
http://dx.doi.org/10.3390/ijms222212382