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Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease

Long-term intake of potential zinc-chelating drugs may cause zinc deficiency. We postulated that zinc deficiency in Parkinson’s disease (PD) patients was related to the intake of drugs such as levodopa. We investigated the relationship between zinc levels and levodopa administration period, dosage,...

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Autores principales: Matsuyama, Hirofumi, Matsuura, Keita, Ishikawa, Hidehiro, Hirata, Yoshinori, Kato, Natsuko, Niwa, Atsushi, Narita, Yugo, Tomimoto, Hidekazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621473/
https://www.ncbi.nlm.nih.gov/pubmed/34836369
http://dx.doi.org/10.3390/nu13114114
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author Matsuyama, Hirofumi
Matsuura, Keita
Ishikawa, Hidehiro
Hirata, Yoshinori
Kato, Natsuko
Niwa, Atsushi
Narita, Yugo
Tomimoto, Hidekazu
author_facet Matsuyama, Hirofumi
Matsuura, Keita
Ishikawa, Hidehiro
Hirata, Yoshinori
Kato, Natsuko
Niwa, Atsushi
Narita, Yugo
Tomimoto, Hidekazu
author_sort Matsuyama, Hirofumi
collection PubMed
description Long-term intake of potential zinc-chelating drugs may cause zinc deficiency. We postulated that zinc deficiency in Parkinson’s disease (PD) patients was related to the intake of drugs such as levodopa. We investigated the relationship between zinc levels and levodopa administration period, dosage, and symptoms of zinc deficiency in PD patients. We measured serum zinc levels and analyzed correlations between serum zinc levels, the levodopa oral administration period, dosage, dosing frequency, and zinc deficiency symptoms including taste disorders. Data analyses were performed using Spearman’s rank correlation coefficient. The mean serum zinc level was 60.5 ± 11.6 μg/dL. The mean administration period for levodopa was 8.0 ± 5.5 years, mean administration frequency 3.4 ± 0.9 times/d, and mean administration dose 420.6 ± 237.1 mg/d. Negative correlations between zinc levels and levodopa dosage and dosing frequency were found. Multiple regression analysis showed a significant correlation with the frequency of levodopa (β = −0.360, p = 0.007). No significant change in clinical symptoms was observed after zinc administration, but anxiety tended to improve. Our results indicated that frequent levodopa administration strongly influenced serum zinc levels which may have alleviating effects on psychiatric symptoms; therefore, preventing zinc deficiency can be important during PD treatment.
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spelling pubmed-86214732021-11-27 Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease Matsuyama, Hirofumi Matsuura, Keita Ishikawa, Hidehiro Hirata, Yoshinori Kato, Natsuko Niwa, Atsushi Narita, Yugo Tomimoto, Hidekazu Nutrients Article Long-term intake of potential zinc-chelating drugs may cause zinc deficiency. We postulated that zinc deficiency in Parkinson’s disease (PD) patients was related to the intake of drugs such as levodopa. We investigated the relationship between zinc levels and levodopa administration period, dosage, and symptoms of zinc deficiency in PD patients. We measured serum zinc levels and analyzed correlations between serum zinc levels, the levodopa oral administration period, dosage, dosing frequency, and zinc deficiency symptoms including taste disorders. Data analyses were performed using Spearman’s rank correlation coefficient. The mean serum zinc level was 60.5 ± 11.6 μg/dL. The mean administration period for levodopa was 8.0 ± 5.5 years, mean administration frequency 3.4 ± 0.9 times/d, and mean administration dose 420.6 ± 237.1 mg/d. Negative correlations between zinc levels and levodopa dosage and dosing frequency were found. Multiple regression analysis showed a significant correlation with the frequency of levodopa (β = −0.360, p = 0.007). No significant change in clinical symptoms was observed after zinc administration, but anxiety tended to improve. Our results indicated that frequent levodopa administration strongly influenced serum zinc levels which may have alleviating effects on psychiatric symptoms; therefore, preventing zinc deficiency can be important during PD treatment. MDPI 2021-11-17 /pmc/articles/PMC8621473/ /pubmed/34836369 http://dx.doi.org/10.3390/nu13114114 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Matsuyama, Hirofumi
Matsuura, Keita
Ishikawa, Hidehiro
Hirata, Yoshinori
Kato, Natsuko
Niwa, Atsushi
Narita, Yugo
Tomimoto, Hidekazu
Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease
title Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease
title_full Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease
title_fullStr Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease
title_full_unstemmed Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease
title_short Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease
title_sort correlation between serum zinc levels and levodopa in parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621473/
https://www.ncbi.nlm.nih.gov/pubmed/34836369
http://dx.doi.org/10.3390/nu13114114
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