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Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy

Cancer immunotherapy is becoming more important in the clinical setting, especially for cancers resistant to conventional chemotherapy, including targeted therapy. Chimeric antigen receptor (CAR)-T cell therapy, which uses patient’s autologous T cells, combined with engineered T cell receptors, has...

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Detalles Bibliográficos
Autores principales: Chung, Hyunmin, Jung, Haiyoung, Noh, Ji-Yoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621681/
https://www.ncbi.nlm.nih.gov/pubmed/34830003
http://dx.doi.org/10.3390/ijms222212126
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author Chung, Hyunmin
Jung, Haiyoung
Noh, Ji-Yoon
author_facet Chung, Hyunmin
Jung, Haiyoung
Noh, Ji-Yoon
author_sort Chung, Hyunmin
collection PubMed
description Cancer immunotherapy is becoming more important in the clinical setting, especially for cancers resistant to conventional chemotherapy, including targeted therapy. Chimeric antigen receptor (CAR)-T cell therapy, which uses patient’s autologous T cells, combined with engineered T cell receptors, has shown remarkable results, with five US Food and Drug Administration (FDA) approvals to date. CAR-T cells have been very effective in hematologic malignancies, such as diffuse large B cell lymphoma (DLBCL), B cell acute lymphoblastic leukemia (B-ALL), and multiple myeloma (MM); however, its effectiveness in treating solid tumors has not been evaluated clearly. Therefore, many studies and clinical investigations are emerging to improve the CAR-T cell efficacy in solid tumors. The novel therapeutic approaches include modifying CARs in multiple ways or developing a combination therapy with immune checkpoint inhibitors and chemotherapies. In this review, we focus on the challenges and recent advancements in CAR-T cell therapy for solid tumors.
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spelling pubmed-86216812021-11-27 Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy Chung, Hyunmin Jung, Haiyoung Noh, Ji-Yoon Int J Mol Sci Review Cancer immunotherapy is becoming more important in the clinical setting, especially for cancers resistant to conventional chemotherapy, including targeted therapy. Chimeric antigen receptor (CAR)-T cell therapy, which uses patient’s autologous T cells, combined with engineered T cell receptors, has shown remarkable results, with five US Food and Drug Administration (FDA) approvals to date. CAR-T cells have been very effective in hematologic malignancies, such as diffuse large B cell lymphoma (DLBCL), B cell acute lymphoblastic leukemia (B-ALL), and multiple myeloma (MM); however, its effectiveness in treating solid tumors has not been evaluated clearly. Therefore, many studies and clinical investigations are emerging to improve the CAR-T cell efficacy in solid tumors. The novel therapeutic approaches include modifying CARs in multiple ways or developing a combination therapy with immune checkpoint inhibitors and chemotherapies. In this review, we focus on the challenges and recent advancements in CAR-T cell therapy for solid tumors. MDPI 2021-11-09 /pmc/articles/PMC8621681/ /pubmed/34830003 http://dx.doi.org/10.3390/ijms222212126 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chung, Hyunmin
Jung, Haiyoung
Noh, Ji-Yoon
Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy
title Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy
title_full Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy
title_fullStr Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy
title_full_unstemmed Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy
title_short Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy
title_sort emerging approaches for solid tumor treatment using car-t cell therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621681/
https://www.ncbi.nlm.nih.gov/pubmed/34830003
http://dx.doi.org/10.3390/ijms222212126
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