The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome

Wolfram syndrome (WS) 1 is a rare monogenic neurodegenerative disorder caused by mutations in the gene encoding WFS1. Knowledge of the pathophysiology of WS is incomplete and to date, there is no treatment available. Here, we describe early deviations in the renin-angiotensin-aldosterone system (RAA...

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Detalles Bibliográficos
Autores principales: Punapart, Marite, Seppa, Kadri, Jagomäe, Toomas, Liiv, Mailis, Reimets, Riin, Kirillov, Silvia, Kaasik, Allen, Moons, Lieve, De Groef, Lies, Terasmaa, Anton, Vasar, Eero, Plaas, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621801/
https://www.ncbi.nlm.nih.gov/pubmed/34828323
http://dx.doi.org/10.3390/genes12111717

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