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Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review
Many flavonoids, as eminent phenolic compounds, have been commercialized and consumed as dietary supplements due to their incredible human health benefits. In the present study, a bioactive flavone glycoside linarin (LN) was designated to comprehensively overview its phytochemical and biological pro...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621830/ https://www.ncbi.nlm.nih.gov/pubmed/34832886 http://dx.doi.org/10.3390/ph14111104 |
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author | Mottaghipisheh, Javad Taghrir, Hadi Boveiri Dehsheikh, Anahita Zomorodian, Kamiar Irajie, Cambyz Mahmoodi Sourestani, Mohammad Iraji, Aida |
author_facet | Mottaghipisheh, Javad Taghrir, Hadi Boveiri Dehsheikh, Anahita Zomorodian, Kamiar Irajie, Cambyz Mahmoodi Sourestani, Mohammad Iraji, Aida |
author_sort | Mottaghipisheh, Javad |
collection | PubMed |
description | Many flavonoids, as eminent phenolic compounds, have been commercialized and consumed as dietary supplements due to their incredible human health benefits. In the present study, a bioactive flavone glycoside linarin (LN) was designated to comprehensively overview its phytochemical and biological properties. LN has been characterized abundantly in the Cirsium, Micromeria, and Buddleja species belonging to Asteraceae, Lamiaceae, and Scrophulariaceae families, respectively. Biological assessments exhibited promising activities of LN, particularly, the remedial effects on central nervous system (CNS) disorders, whereas the remarkable sleep enhancing and sedative effects as well as AChE (acetylcholinesterase) inhibitory activity were highlighted. Of note, LN has indicated promising anti osteoblast proliferation and differentiation, thus a bone formation effect. Further biological and pharmacological assessments of LN and its optimized semi-synthetic derivatives, specifically its therapeutic characteristics on osteoarthritis and osteoporosis, might lead to uncovering potential drug candidates. |
format | Online Article Text |
id | pubmed-8621830 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86218302021-11-27 Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review Mottaghipisheh, Javad Taghrir, Hadi Boveiri Dehsheikh, Anahita Zomorodian, Kamiar Irajie, Cambyz Mahmoodi Sourestani, Mohammad Iraji, Aida Pharmaceuticals (Basel) Review Many flavonoids, as eminent phenolic compounds, have been commercialized and consumed as dietary supplements due to their incredible human health benefits. In the present study, a bioactive flavone glycoside linarin (LN) was designated to comprehensively overview its phytochemical and biological properties. LN has been characterized abundantly in the Cirsium, Micromeria, and Buddleja species belonging to Asteraceae, Lamiaceae, and Scrophulariaceae families, respectively. Biological assessments exhibited promising activities of LN, particularly, the remedial effects on central nervous system (CNS) disorders, whereas the remarkable sleep enhancing and sedative effects as well as AChE (acetylcholinesterase) inhibitory activity were highlighted. Of note, LN has indicated promising anti osteoblast proliferation and differentiation, thus a bone formation effect. Further biological and pharmacological assessments of LN and its optimized semi-synthetic derivatives, specifically its therapeutic characteristics on osteoarthritis and osteoporosis, might lead to uncovering potential drug candidates. MDPI 2021-10-29 /pmc/articles/PMC8621830/ /pubmed/34832886 http://dx.doi.org/10.3390/ph14111104 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mottaghipisheh, Javad Taghrir, Hadi Boveiri Dehsheikh, Anahita Zomorodian, Kamiar Irajie, Cambyz Mahmoodi Sourestani, Mohammad Iraji, Aida Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review |
title | Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review |
title_full | Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review |
title_fullStr | Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review |
title_full_unstemmed | Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review |
title_short | Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review |
title_sort | linarin, a glycosylated flavonoid, with potential therapeutic attributes: a comprehensive review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621830/ https://www.ncbi.nlm.nih.gov/pubmed/34832886 http://dx.doi.org/10.3390/ph14111104 |
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