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Structural Insights into the Azole Resistance of the Candida albicans Darlington Strain Using Saccharomyces cerevisiae Lanosterol 14α-Demethylase as a Surrogate

Target-based azole resistance in Candida albicans involves overexpression of the ERG11 gene encoding lanosterol 14α-demethylase (LDM), and/or the presence of single or multiple mutations in this enzyme. Overexpression of Candida albicans LDM (CaLDM) Y132H I471T by the Darlington strain strongly incr...

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Detalles Bibliográficos
Autores principales:	Graham, Danyon O., Wilson, Rajni K., Ruma, Yasmeen N., Keniya, Mikhail V., Tyndall, Joel D. A., Monk, Brian C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621857/ https://www.ncbi.nlm.nih.gov/pubmed/34829185 http://dx.doi.org/10.3390/jof7110897

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