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Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor bioavailability, which is a major challenge whe...

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Autores principales: Gupta, Bharti, Mishra, Varsha, Gharat, Sankalp, Momin, Munira, Omri, Abdelwahab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621906/
https://www.ncbi.nlm.nih.gov/pubmed/34832983
http://dx.doi.org/10.3390/ph14111201
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author Gupta, Bharti
Mishra, Varsha
Gharat, Sankalp
Momin, Munira
Omri, Abdelwahab
author_facet Gupta, Bharti
Mishra, Varsha
Gharat, Sankalp
Momin, Munira
Omri, Abdelwahab
author_sort Gupta, Bharti
collection PubMed
description One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor bioavailability, which is a major challenge when one has to develop an ocular drug delivery system. The outer lipid layer, pre-corneal, dynamic, and static ocular barriers limit drug availability to the targeted ocular tissues. Biopharmaceutical Classification System (BCS) class II drugs with adequate permeability and limited or no aqueous solubility have been extensively studied for various polymer-based solubility enhancement approaches. The hydrophilic nature of cellulosic polymers and their tunable properties make them the polymers of choice in various solubility-enhancement techniques. This review focuses on various cellulose derivatives, specifically, their role, current status and novel modified cellulosic polymers for enhancing the bioavailability of BCS class II drugs in ocular drug delivery systems.
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spelling pubmed-86219062021-11-27 Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems Gupta, Bharti Mishra, Varsha Gharat, Sankalp Momin, Munira Omri, Abdelwahab Pharmaceuticals (Basel) Review One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor bioavailability, which is a major challenge when one has to develop an ocular drug delivery system. The outer lipid layer, pre-corneal, dynamic, and static ocular barriers limit drug availability to the targeted ocular tissues. Biopharmaceutical Classification System (BCS) class II drugs with adequate permeability and limited or no aqueous solubility have been extensively studied for various polymer-based solubility enhancement approaches. The hydrophilic nature of cellulosic polymers and their tunable properties make them the polymers of choice in various solubility-enhancement techniques. This review focuses on various cellulose derivatives, specifically, their role, current status and novel modified cellulosic polymers for enhancing the bioavailability of BCS class II drugs in ocular drug delivery systems. MDPI 2021-11-22 /pmc/articles/PMC8621906/ /pubmed/34832983 http://dx.doi.org/10.3390/ph14111201 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gupta, Bharti
Mishra, Varsha
Gharat, Sankalp
Momin, Munira
Omri, Abdelwahab
Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
title Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
title_full Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
title_fullStr Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
title_full_unstemmed Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
title_short Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
title_sort cellulosic polymers for enhancing drug bioavailability in ocular drug delivery systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621906/
https://www.ncbi.nlm.nih.gov/pubmed/34832983
http://dx.doi.org/10.3390/ph14111201
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