A Yeast-Based Repurposing Approach for the Treatment of Mitochondrial DNA Depletion Syndromes Led to the Identification of Molecules Able to Modulate the dNTP Pool

Mitochondrial DNA depletion syndromes (MDS) are clinically heterogenous and often severe diseases, characterized by a reduction of the number of copies of mitochondrial DNA (mtDNA) in affected tissues. In the context of MDS, yeast has proved to be both an excellent model for the study of the mechani...

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Detalles Bibliográficos
Autores principales: di Punzio, Giulia, Gilberti, Micol, Baruffini, Enrico, Lodi, Tiziana, Donnini, Claudia, Dallabona, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621932/
https://www.ncbi.nlm.nih.gov/pubmed/34830106
http://dx.doi.org/10.3390/ijms222212223

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