Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons

Among the nine mammalian protein arginine methyltransferases (PRMTs), PRMT8 is unusual because it has restricted expression in the nervous system and is the only membrane-bound PRMT. Emerging studies have demonstrated that this enzyme plays multifaceted roles in diverse processes in neurons. Here we...

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Detalles Bibliográficos
Autores principales: Dong, Rui, Li, Xuejun, Lai, Kwok-On
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621972/
https://www.ncbi.nlm.nih.gov/pubmed/34833008
http://dx.doi.org/10.3390/life11111132
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author Dong, Rui
Li, Xuejun
Lai, Kwok-On
author_facet Dong, Rui
Li, Xuejun
Lai, Kwok-On
author_sort Dong, Rui
collection PubMed
description Among the nine mammalian protein arginine methyltransferases (PRMTs), PRMT8 is unusual because it has restricted expression in the nervous system and is the only membrane-bound PRMT. Emerging studies have demonstrated that this enzyme plays multifaceted roles in diverse processes in neurons. Here we will summarize the unique structural features of PRMT8 and describe how it participates in various neuronal functions such as dendritic growth, synapse maturation, and synaptic plasticity. Recent evidence suggesting the potential role of PRMT8 function in neurological diseases will also be discussed.
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spelling pubmed-86219722021-11-27 Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons Dong, Rui Li, Xuejun Lai, Kwok-On Life (Basel) Review Among the nine mammalian protein arginine methyltransferases (PRMTs), PRMT8 is unusual because it has restricted expression in the nervous system and is the only membrane-bound PRMT. Emerging studies have demonstrated that this enzyme plays multifaceted roles in diverse processes in neurons. Here we will summarize the unique structural features of PRMT8 and describe how it participates in various neuronal functions such as dendritic growth, synapse maturation, and synaptic plasticity. Recent evidence suggesting the potential role of PRMT8 function in neurological diseases will also be discussed. MDPI 2021-10-24 /pmc/articles/PMC8621972/ /pubmed/34833008 http://dx.doi.org/10.3390/life11111132 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dong, Rui
Li, Xuejun
Lai, Kwok-On
Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons
title Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons
title_full Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons
title_fullStr Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons
title_full_unstemmed Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons
title_short Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons
title_sort activity and function of the prmt8 protein arginine methyltransferase in neurons
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621972/
https://www.ncbi.nlm.nih.gov/pubmed/34833008
http://dx.doi.org/10.3390/life11111132
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