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Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study

Objectives: To compare the application value of digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) in breast galactography. Materials and Methods: A total of 128 patients with pathological nipple discharge (PND) were selected to undergo galactography. DBT and FFDM were perf...

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Autores principales: Tao, Juan, Liao, Hao, Liu, Yuan, Peng, Qingsong, Zhu, Wenying, Peng, Shuyi, Liu, Jie, Chen, Leqing, Yang, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622426/
https://www.ncbi.nlm.nih.gov/pubmed/34829407
http://dx.doi.org/10.3390/diagnostics11112060
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author Tao, Juan
Liao, Hao
Liu, Yuan
Peng, Qingsong
Zhu, Wenying
Peng, Shuyi
Liu, Jie
Chen, Leqing
Yang, Fan
author_facet Tao, Juan
Liao, Hao
Liu, Yuan
Peng, Qingsong
Zhu, Wenying
Peng, Shuyi
Liu, Jie
Chen, Leqing
Yang, Fan
author_sort Tao, Juan
collection PubMed
description Objectives: To compare the application value of digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) in breast galactography. Materials and Methods: A total of 128 patients with pathological nipple discharge (PND) were selected to undergo galactography. DBT and FFDM were performed for each patient after injecting the contrast agent; the radiation dose of DBT and FFDM was calculated, and the image quality was evaluated in consensus by two senior breast radiologists. Histopathologic data were found in 49 of the 128 patients. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for both FFDM- and DBT-galactography were calculated using histopathologic results as a reference standard. Data were presented as percentages along with their 95% confidence intervals (CI). Results: The average age of the 128 patients was 46.53 years. The average glandular dose (AGD) of DBT-galactography was slightly higher than that of FFDM-galactography (p < 0.001). DBT-galactography was 30.7% higher than FFDM-galactography in CC view, while DBT-galactography increased by 21.7% compared with FFDM-galactography in ML view. Regarding catheter anatomic distortion, structure detail, and overall image quality groups, DBT scores were higher than FFDM scores, and the differences were significant for all measures (p < 0.05). In 49 patients with pathological nipple discharge, we found that the DBT-galactography had higher sensitivity, specificity, PPV, and NPV (93.3%, 75%, 97.7%, and 50%, respectively) than FFDM-galactography (91.1%, 50%, 95.3%, and 33.3%, respectively). Conclusions: Compared to FFDM-galactography, within the acceptable radiation dose range, DBT-galactography increases the sensitivity and specificity of lesion detection by improving the image quality, providing more confidence for the diagnosis of clinical ductal lesions.
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spelling pubmed-86224262021-11-27 Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study Tao, Juan Liao, Hao Liu, Yuan Peng, Qingsong Zhu, Wenying Peng, Shuyi Liu, Jie Chen, Leqing Yang, Fan Diagnostics (Basel) Article Objectives: To compare the application value of digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) in breast galactography. Materials and Methods: A total of 128 patients with pathological nipple discharge (PND) were selected to undergo galactography. DBT and FFDM were performed for each patient after injecting the contrast agent; the radiation dose of DBT and FFDM was calculated, and the image quality was evaluated in consensus by two senior breast radiologists. Histopathologic data were found in 49 of the 128 patients. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for both FFDM- and DBT-galactography were calculated using histopathologic results as a reference standard. Data were presented as percentages along with their 95% confidence intervals (CI). Results: The average age of the 128 patients was 46.53 years. The average glandular dose (AGD) of DBT-galactography was slightly higher than that of FFDM-galactography (p < 0.001). DBT-galactography was 30.7% higher than FFDM-galactography in CC view, while DBT-galactography increased by 21.7% compared with FFDM-galactography in ML view. Regarding catheter anatomic distortion, structure detail, and overall image quality groups, DBT scores were higher than FFDM scores, and the differences were significant for all measures (p < 0.05). In 49 patients with pathological nipple discharge, we found that the DBT-galactography had higher sensitivity, specificity, PPV, and NPV (93.3%, 75%, 97.7%, and 50%, respectively) than FFDM-galactography (91.1%, 50%, 95.3%, and 33.3%, respectively). Conclusions: Compared to FFDM-galactography, within the acceptable radiation dose range, DBT-galactography increases the sensitivity and specificity of lesion detection by improving the image quality, providing more confidence for the diagnosis of clinical ductal lesions. MDPI 2021-11-07 /pmc/articles/PMC8622426/ /pubmed/34829407 http://dx.doi.org/10.3390/diagnostics11112060 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tao, Juan
Liao, Hao
Liu, Yuan
Peng, Qingsong
Zhu, Wenying
Peng, Shuyi
Liu, Jie
Chen, Leqing
Yang, Fan
Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study
title Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study
title_full Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study
title_fullStr Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study
title_full_unstemmed Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study
title_short Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study
title_sort evaluation of breast galactography using digital breast tomosynthesis: a clinical exploratory study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622426/
https://www.ncbi.nlm.nih.gov/pubmed/34829407
http://dx.doi.org/10.3390/diagnostics11112060
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