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Serum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients

Redox status disturbances are known during carcinogenesis and may have influence on patients’ survival. However, the prediction of mortality in lung cancer patients based on serum total SOD activity, and concentrations of its isoforms, has not been studied to date. This prospective cohort study has...

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Autores principales: Skórska, Katarzyna Beata, Płaczkowska, Sylwia, Prescha, Anna, Porębska, Irena, Kosacka, Monika, Pawełczyk, Konrad, Zabłocka-Słowińska, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622563/
https://www.ncbi.nlm.nih.gov/pubmed/34832849
http://dx.doi.org/10.3390/ph14111067
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author Skórska, Katarzyna Beata
Płaczkowska, Sylwia
Prescha, Anna
Porębska, Irena
Kosacka, Monika
Pawełczyk, Konrad
Zabłocka-Słowińska, Katarzyna
author_facet Skórska, Katarzyna Beata
Płaczkowska, Sylwia
Prescha, Anna
Porębska, Irena
Kosacka, Monika
Pawełczyk, Konrad
Zabłocka-Słowińska, Katarzyna
author_sort Skórska, Katarzyna Beata
collection PubMed
description Redox status disturbances are known during carcinogenesis and may have influence on patients’ survival. However, the prediction of mortality in lung cancer patients based on serum total SOD activity, and concentrations of its isoforms, has not been studied to date. This prospective cohort study has following aims: (1) to evaluate the disturbances in serum SOD activity and SOD1/2 concentrations; (2) to assess the implications of these alterations with regard to biochemical variables and clinical data, and (3) to investigate the association between serum SOD activity, SOD1/2 concentrations, and all-cause mortality in lung cancer patients. Serum total SOD activity and SOD1, SOD2, albumin, CRP, and ceruloplasmin concentrations were determined in lung cancer patients (n = 190) and control subjects (n = 52). Additionally, patients were characterized in terms of biochemical, clinical, and sociodemographic data. Multiple Cox regression models were used to estimate the association between all-cause death and SOD-related parameters. All-cause mortality in lung cancer was positively associated with serum SOD1 and SOD2 concentrations. Clinical stage III and IV disease was the strongest predictor. The utility of the evaluated parameters in predicting overall survival was demonstrated only for SOD1. Serum SOD1 and SOD2 concentrations were shown to positively affect all-cause mortality in lung cancer patients, but SOD1 seems to be a better predictor than SOD2.
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spelling pubmed-86225632021-11-27 Serum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients Skórska, Katarzyna Beata Płaczkowska, Sylwia Prescha, Anna Porębska, Irena Kosacka, Monika Pawełczyk, Konrad Zabłocka-Słowińska, Katarzyna Pharmaceuticals (Basel) Article Redox status disturbances are known during carcinogenesis and may have influence on patients’ survival. However, the prediction of mortality in lung cancer patients based on serum total SOD activity, and concentrations of its isoforms, has not been studied to date. This prospective cohort study has following aims: (1) to evaluate the disturbances in serum SOD activity and SOD1/2 concentrations; (2) to assess the implications of these alterations with regard to biochemical variables and clinical data, and (3) to investigate the association between serum SOD activity, SOD1/2 concentrations, and all-cause mortality in lung cancer patients. Serum total SOD activity and SOD1, SOD2, albumin, CRP, and ceruloplasmin concentrations were determined in lung cancer patients (n = 190) and control subjects (n = 52). Additionally, patients were characterized in terms of biochemical, clinical, and sociodemographic data. Multiple Cox regression models were used to estimate the association between all-cause death and SOD-related parameters. All-cause mortality in lung cancer was positively associated with serum SOD1 and SOD2 concentrations. Clinical stage III and IV disease was the strongest predictor. The utility of the evaluated parameters in predicting overall survival was demonstrated only for SOD1. Serum SOD1 and SOD2 concentrations were shown to positively affect all-cause mortality in lung cancer patients, but SOD1 seems to be a better predictor than SOD2. MDPI 2021-10-21 /pmc/articles/PMC8622563/ /pubmed/34832849 http://dx.doi.org/10.3390/ph14111067 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Skórska, Katarzyna Beata
Płaczkowska, Sylwia
Prescha, Anna
Porębska, Irena
Kosacka, Monika
Pawełczyk, Konrad
Zabłocka-Słowińska, Katarzyna
Serum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients
title Serum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients
title_full Serum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients
title_fullStr Serum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients
title_full_unstemmed Serum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients
title_short Serum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients
title_sort serum total sod activity and sod1/2 concentrations in predicting all-cause mortality in lung cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622563/
https://www.ncbi.nlm.nih.gov/pubmed/34832849
http://dx.doi.org/10.3390/ph14111067
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