Cargando…

Histamine H(3) Receptor Ligands—KSK-59 and KSK-73—Reduce Body Weight Gain in a Rat Model of Excessive Eating

Noting the worldwide rapid increase in the prevalence of overweight and obesity new effective drugs are now being sought to combat these diseases. Histamine H(3) receptor antagonists may represent an effective therapy as they have been shown to modulate histamine synthesis and release and affect a n...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mika, Kamil, Szafarz, Małgorzata, Bednarski, Marek, Latacz, Gniewomir, Sudoł, Sylwia, Handzlik, Jadwiga, Pociecha, Krzysztof, Knutelska, Joanna, Nicosia, Noemi, Szczepańska, Katarzyna, Kuder, Kamil J., Kieć-Kononowicz, Katarzyna, Kotańska, Magdalena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622623/ https://www.ncbi.nlm.nih.gov/pubmed/34832862 http://dx.doi.org/10.3390/ph14111080

Ejemplares similares

KSK-74: Dual Histamine H(3) and Sigma-2 Receptor Ligand with Anti-Obesity Potential
por: Mika, Kamil, et al.
Publicado: (2022)

Evaluation of Some Safety Parameters of Dual Histamine H(3) and Sigma-2 Receptor Ligands with Anti-Obesity Potential
por: Mika, Kamil, et al.
Publicado: (2023)

The histamine H(3) receptor inverse agonist pitolisant reduces body weight in obese mice
por: Kotańska, Magdalena, et al.
Publicado: (2018)

Discovery of Potential, Dual-Active Histamine H(3) Receptor Ligands with Combined Antioxidant Properties
por: Kuder, Kamil J., et al.
Publicado: (2021)

Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats
por: Sadek, Bassem, et al.
Publicado: (2016)

Structure Prediction, Evaluation, and Validation of GPR18 Lipid Receptor Using Free Programs
por: Michalik, Ilona, et al.
Publicado: (2022)

Diffractive dissociation into $K_sK^{\pm}\pi^{\mp}\pi^{-}$ final states
por: Bernhard, Johannes, et al.
Publicado: (2011)

Preliminary Evidence of the Potent and Selective Adenosine A2B Receptor Antagonist PSB-603 in Reducing Obesity and Some of Its Associated Metabolic Disorders in Mice
por: Kotańska, Magdalena, et al.
Publicado: (2022)

Studies on Anticonvulsant Effects of Novel Histamine H3R Antagonists in Electrically and Chemically Induced Seizures in Rats
por: Alachkar, Alaa, et al.
Publicado: (2018)

Benzophenone Derivatives with Histamine H(3) Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer’s Disease
por: Godyń, Justyna, et al.
Publicado: (2022)

Guanabenz—an old drug with a potential to decrease obesity
por: Kotańska, Magdalena, et al.
Publicado: (2022)

Interleukin-10 as Covid-19 biomarker targeting KSK and its analogues: Integrated network pharmacology
por: V., Vidhya Rajalakshmi, et al.
Publicado: (2023)

The Stereoselectivity and Hydrolysis Efficiency of Recombinant d-Hydantoinase from Vigna angularis Against 5-Benzylhydantoin Derivatives with Halogen and Methyl Substituents
por: Latacz, Gniewomir, et al.
Publicado: (2014)

The GPR18 Agonist PSB-KD-107 Exerts Endothelium-Dependent Vasorelaxant Effects
por: Kotańska, Magdalena, et al.
Publicado: (2021)

H(3) histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice
por: Dudek, Magdalena, et al.
Publicado: (2016)

KD-64—A new selective A(2A) adenosine receptor antagonist has anti-inflammatory activity but contrary to the non-selective antagonist—Caffeine does not reduce diet-induced obesity in mice
por: Kotańska, Magdalena, et al.
Publicado: (2020)

The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT(6) Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment
por: Latacz, Gniewomir, et al.
Publicado: (2019)

Effects of GPR18 Ligands on Body Weight and Metabolic Parameters in a Female Rat Model of Excessive Eating
por: Kotańska, Magdalena, et al.
Publicado: (2021)

Phenylpiperazine 5,5-Dimethylhydantoin Derivatives as First Synthetic Inhibitors of Msr(A) Efflux Pump in Staphylococcus epidermidis
por: Witek, Karolina, et al.
Publicado: (2020)

Search for CP violation in the $D_s^+ \rightarrow K_s\pi^+, D^+ \rightarrow K_sK^+$ and $D^+ \rightarrow \phi\pi^+$ decays
por: Maccolini, Serena
Publicado: (2019)

Are the Hydantoin-1,3,5-triazine 5-HT(6)R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro
por: Lubelska, Annamaria, et al.
Publicado: (2019)

LC–MS–MS Method for the Analysis of New Non-Imidazole Histamine H(3) Receptor Antagonist 1-[3-(4-tert-Butylphenoxy)propyl]piperidine in Rat Serum—Application to Pharmacokinetic Studies
por: Szafarz, Malgorzata, et al.
Publicado: (2011)

Recent Advances in Multi-Drug Resistance (MDR) Efflux Pump Inhibitors of Gram-Positive Bacteria S. aureus
por: Handzlik, Jadwiga, et al.
Publicado: (2013)

Trisubstituted 1,3,5-Triazines as Histamine H(4) Receptor Antagonists with Promising Activity In Vivo
por: Olejarz-Maciej, Agnieszka, et al.
Publicado: (2023)

A Taxicab geometry quantification system to evaluate the performance of in silico methods: a case study on adenosine receptors ligands
por: Kuder, Kamil J., et al.
Publicado: (2020)

Aspects of a Distinct Cytotoxicity of Selenium Salts and Organic Selenides in Living Cells with Possible Implications for Drug Design
por: Castellucci Estevam, Ethiene, et al.
Publicado: (2015)

The Potent and Selective Histamine H3 Receptor Antagonist E169 Counteracts Cognitive Deficits and Mitigates Disturbances in the PI3K/AKT/GSK-3β Signaling Pathway in MK801-Induced Amnesia in Mice
por: Abdalla, Sabna, et al.
Publicado: (2023)

Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT(6) Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo
por: Kurczab, Rafał, et al.
Publicado: (2018)

Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H(3) Receptor Antagonists and Monoamine Oxidase B Inhibitors
por: Łażewska, Dorota, et al.
Publicado: (2020)

Selenazolinium Salts as “Small Molecule Catalysts” with High Potency against ESKAPE Bacterial Pathogens
por: Witek, Karolina, et al.
Publicado: (2017)

Antiplatelet Effects of Selected Xanthine-Based Adenosine A(2A) and A(2B) Receptor Antagonists Determined in Rat Blood
por: Kubacka, Monika, et al.
Publicado: (2023)

Manifestations of Liver Impairment and the Effects of MH-76, a Non-Quinazoline α1-Adrenoceptor Antagonist, and Prazosin on Liver Tissue in Fructose-Induced Metabolic Syndrome
por: Kubacka, Monika, et al.
Publicado: (2023)

Salsolinol—neurotoxic or Neuroprotective?
por: Kurnik-Łucka, Magdalena, et al.
Publicado: (2019)

5-Arylideneimidazolones with Amine at Position 3 as Potential Antibiotic Adjuvants against Multidrug Resistant Bacteria
por: Kaczor, Aneta, et al.
Publicado: (2019)

The Structural Determinants for α(1)-Adrenergic/Serotonin Receptors Activity among Phenylpiperazine-Hydantoin Derivatives
por: Kucwaj-Brysz, Katarzyna, et al.
Publicado: (2021)

Low-basicity 5-HT(7) Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol
por: Hogendorf, Adam S., et al.
Publicado: (2017)

Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A(2A) and Dual A(1)/A(2A) Receptor Affinity
por: Załuski, Michał, et al.
Publicado: (2023)

Study on the effect of EMD386088, a 5-HT(6) receptor partial agonist, in enhancing the anti-immobility action of some antidepressants in rats
por: Jastrzębska-Więsek, Magdalena, et al.
Publicado: (2017)

The efficacy of Siddha Medicine, Kabasura Kudineer (KSK) compared to Vitamin C & Zinc (CZ) supplementation in the management of asymptomatic COVID-19 cases: A structured summary of a study protocol for a randomised controlled trial
por: Natarajan, S., et al.
Publicado: (2020)

The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats
por: Alachkar, Alaa, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_bc2idrorvvsjls03j8nlvsek5u