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Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections

Survivors of severe SARS-CoV-2 infections frequently suffer from a range of post-infection sequelae. Whether survivors of mild or asymptomatic infections can expect any long-term health consequences is not yet known. Herein we investigated lasting changes to soluble inflammatory factors and cellular...

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Autores principales: Kennedy, Allison E., Cook, Laura, Breznik, Jessica A., Cowbrough, Braeden, Wallace, Jessica G., Huynh, Angela, Smith, James W., Son, Kiho, Stacey, Hannah, Ang, Jann, McGeer, Allison, Coleman, Brenda L., Larché, Maggie, Larché, Mark, Hambly, Nathan, Nair, Parameswaran, Ask, Kjetil, Miller, Matthew S., Bramson, Jonathan, Levings, Megan K., Nazy, Ishac, Svenningsen, Sarah, Mukherjee, Manali, Bowdish, Dawn M. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622816/
https://www.ncbi.nlm.nih.gov/pubmed/34835045
http://dx.doi.org/10.3390/v13112239
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author Kennedy, Allison E.
Cook, Laura
Breznik, Jessica A.
Cowbrough, Braeden
Wallace, Jessica G.
Huynh, Angela
Smith, James W.
Son, Kiho
Stacey, Hannah
Ang, Jann
McGeer, Allison
Coleman, Brenda L.
Larché, Maggie
Larché, Mark
Hambly, Nathan
Nair, Parameswaran
Ask, Kjetil
Miller, Matthew S.
Bramson, Jonathan
Levings, Megan K.
Nazy, Ishac
Svenningsen, Sarah
Mukherjee, Manali
Bowdish, Dawn M. E.
author_facet Kennedy, Allison E.
Cook, Laura
Breznik, Jessica A.
Cowbrough, Braeden
Wallace, Jessica G.
Huynh, Angela
Smith, James W.
Son, Kiho
Stacey, Hannah
Ang, Jann
McGeer, Allison
Coleman, Brenda L.
Larché, Maggie
Larché, Mark
Hambly, Nathan
Nair, Parameswaran
Ask, Kjetil
Miller, Matthew S.
Bramson, Jonathan
Levings, Megan K.
Nazy, Ishac
Svenningsen, Sarah
Mukherjee, Manali
Bowdish, Dawn M. E.
author_sort Kennedy, Allison E.
collection PubMed
description Survivors of severe SARS-CoV-2 infections frequently suffer from a range of post-infection sequelae. Whether survivors of mild or asymptomatic infections can expect any long-term health consequences is not yet known. Herein we investigated lasting changes to soluble inflammatory factors and cellular immune phenotype and function in individuals who had recovered from mild SARS-CoV-2 infections (n = 22), compared to those that had recovered from other mild respiratory infections (n = 11). Individuals who had experienced mild SARS-CoV-2 infections had elevated levels of C-reactive protein 1–3 months after symptom onset, and changes in phenotype and function of circulating T-cells that were not apparent in individuals 6–9 months post-symptom onset. Markers of monocyte activation, and expression of adherence and chemokine receptors indicative of altered migratory capacity, were also higher at 1–3 months post-infection in individuals who had mild SARS-CoV-2, but these were no longer elevated by 6–9 months post-infection. Perhaps most surprisingly, significantly more T-cells could be activated by polyclonal stimulation in individuals who had recently experienced a mild SARS-CoV-2, infection compared to individuals with other recent respiratory infections. These data are indicative of prolonged immune activation and systemic inflammation that persists for at least three months after mild or asymptomatic SARS-CoV-2 infections.
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spelling pubmed-86228162021-11-27 Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections Kennedy, Allison E. Cook, Laura Breznik, Jessica A. Cowbrough, Braeden Wallace, Jessica G. Huynh, Angela Smith, James W. Son, Kiho Stacey, Hannah Ang, Jann McGeer, Allison Coleman, Brenda L. Larché, Maggie Larché, Mark Hambly, Nathan Nair, Parameswaran Ask, Kjetil Miller, Matthew S. Bramson, Jonathan Levings, Megan K. Nazy, Ishac Svenningsen, Sarah Mukherjee, Manali Bowdish, Dawn M. E. Viruses Article Survivors of severe SARS-CoV-2 infections frequently suffer from a range of post-infection sequelae. Whether survivors of mild or asymptomatic infections can expect any long-term health consequences is not yet known. Herein we investigated lasting changes to soluble inflammatory factors and cellular immune phenotype and function in individuals who had recovered from mild SARS-CoV-2 infections (n = 22), compared to those that had recovered from other mild respiratory infections (n = 11). Individuals who had experienced mild SARS-CoV-2 infections had elevated levels of C-reactive protein 1–3 months after symptom onset, and changes in phenotype and function of circulating T-cells that were not apparent in individuals 6–9 months post-symptom onset. Markers of monocyte activation, and expression of adherence and chemokine receptors indicative of altered migratory capacity, were also higher at 1–3 months post-infection in individuals who had mild SARS-CoV-2, but these were no longer elevated by 6–9 months post-infection. Perhaps most surprisingly, significantly more T-cells could be activated by polyclonal stimulation in individuals who had recently experienced a mild SARS-CoV-2, infection compared to individuals with other recent respiratory infections. These data are indicative of prolonged immune activation and systemic inflammation that persists for at least three months after mild or asymptomatic SARS-CoV-2 infections. MDPI 2021-11-08 /pmc/articles/PMC8622816/ /pubmed/34835045 http://dx.doi.org/10.3390/v13112239 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kennedy, Allison E.
Cook, Laura
Breznik, Jessica A.
Cowbrough, Braeden
Wallace, Jessica G.
Huynh, Angela
Smith, James W.
Son, Kiho
Stacey, Hannah
Ang, Jann
McGeer, Allison
Coleman, Brenda L.
Larché, Maggie
Larché, Mark
Hambly, Nathan
Nair, Parameswaran
Ask, Kjetil
Miller, Matthew S.
Bramson, Jonathan
Levings, Megan K.
Nazy, Ishac
Svenningsen, Sarah
Mukherjee, Manali
Bowdish, Dawn M. E.
Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections
title Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections
title_full Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections
title_fullStr Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections
title_full_unstemmed Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections
title_short Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections
title_sort lasting changes to circulating leukocytes in people with mild sars-cov-2 infections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622816/
https://www.ncbi.nlm.nih.gov/pubmed/34835045
http://dx.doi.org/10.3390/v13112239
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