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Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections
Survivors of severe SARS-CoV-2 infections frequently suffer from a range of post-infection sequelae. Whether survivors of mild or asymptomatic infections can expect any long-term health consequences is not yet known. Herein we investigated lasting changes to soluble inflammatory factors and cellular...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622816/ https://www.ncbi.nlm.nih.gov/pubmed/34835045 http://dx.doi.org/10.3390/v13112239 |
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author | Kennedy, Allison E. Cook, Laura Breznik, Jessica A. Cowbrough, Braeden Wallace, Jessica G. Huynh, Angela Smith, James W. Son, Kiho Stacey, Hannah Ang, Jann McGeer, Allison Coleman, Brenda L. Larché, Maggie Larché, Mark Hambly, Nathan Nair, Parameswaran Ask, Kjetil Miller, Matthew S. Bramson, Jonathan Levings, Megan K. Nazy, Ishac Svenningsen, Sarah Mukherjee, Manali Bowdish, Dawn M. E. |
author_facet | Kennedy, Allison E. Cook, Laura Breznik, Jessica A. Cowbrough, Braeden Wallace, Jessica G. Huynh, Angela Smith, James W. Son, Kiho Stacey, Hannah Ang, Jann McGeer, Allison Coleman, Brenda L. Larché, Maggie Larché, Mark Hambly, Nathan Nair, Parameswaran Ask, Kjetil Miller, Matthew S. Bramson, Jonathan Levings, Megan K. Nazy, Ishac Svenningsen, Sarah Mukherjee, Manali Bowdish, Dawn M. E. |
author_sort | Kennedy, Allison E. |
collection | PubMed |
description | Survivors of severe SARS-CoV-2 infections frequently suffer from a range of post-infection sequelae. Whether survivors of mild or asymptomatic infections can expect any long-term health consequences is not yet known. Herein we investigated lasting changes to soluble inflammatory factors and cellular immune phenotype and function in individuals who had recovered from mild SARS-CoV-2 infections (n = 22), compared to those that had recovered from other mild respiratory infections (n = 11). Individuals who had experienced mild SARS-CoV-2 infections had elevated levels of C-reactive protein 1–3 months after symptom onset, and changes in phenotype and function of circulating T-cells that were not apparent in individuals 6–9 months post-symptom onset. Markers of monocyte activation, and expression of adherence and chemokine receptors indicative of altered migratory capacity, were also higher at 1–3 months post-infection in individuals who had mild SARS-CoV-2, but these were no longer elevated by 6–9 months post-infection. Perhaps most surprisingly, significantly more T-cells could be activated by polyclonal stimulation in individuals who had recently experienced a mild SARS-CoV-2, infection compared to individuals with other recent respiratory infections. These data are indicative of prolonged immune activation and systemic inflammation that persists for at least three months after mild or asymptomatic SARS-CoV-2 infections. |
format | Online Article Text |
id | pubmed-8622816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86228162021-11-27 Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections Kennedy, Allison E. Cook, Laura Breznik, Jessica A. Cowbrough, Braeden Wallace, Jessica G. Huynh, Angela Smith, James W. Son, Kiho Stacey, Hannah Ang, Jann McGeer, Allison Coleman, Brenda L. Larché, Maggie Larché, Mark Hambly, Nathan Nair, Parameswaran Ask, Kjetil Miller, Matthew S. Bramson, Jonathan Levings, Megan K. Nazy, Ishac Svenningsen, Sarah Mukherjee, Manali Bowdish, Dawn M. E. Viruses Article Survivors of severe SARS-CoV-2 infections frequently suffer from a range of post-infection sequelae. Whether survivors of mild or asymptomatic infections can expect any long-term health consequences is not yet known. Herein we investigated lasting changes to soluble inflammatory factors and cellular immune phenotype and function in individuals who had recovered from mild SARS-CoV-2 infections (n = 22), compared to those that had recovered from other mild respiratory infections (n = 11). Individuals who had experienced mild SARS-CoV-2 infections had elevated levels of C-reactive protein 1–3 months after symptom onset, and changes in phenotype and function of circulating T-cells that were not apparent in individuals 6–9 months post-symptom onset. Markers of monocyte activation, and expression of adherence and chemokine receptors indicative of altered migratory capacity, were also higher at 1–3 months post-infection in individuals who had mild SARS-CoV-2, but these were no longer elevated by 6–9 months post-infection. Perhaps most surprisingly, significantly more T-cells could be activated by polyclonal stimulation in individuals who had recently experienced a mild SARS-CoV-2, infection compared to individuals with other recent respiratory infections. These data are indicative of prolonged immune activation and systemic inflammation that persists for at least three months after mild or asymptomatic SARS-CoV-2 infections. MDPI 2021-11-08 /pmc/articles/PMC8622816/ /pubmed/34835045 http://dx.doi.org/10.3390/v13112239 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kennedy, Allison E. Cook, Laura Breznik, Jessica A. Cowbrough, Braeden Wallace, Jessica G. Huynh, Angela Smith, James W. Son, Kiho Stacey, Hannah Ang, Jann McGeer, Allison Coleman, Brenda L. Larché, Maggie Larché, Mark Hambly, Nathan Nair, Parameswaran Ask, Kjetil Miller, Matthew S. Bramson, Jonathan Levings, Megan K. Nazy, Ishac Svenningsen, Sarah Mukherjee, Manali Bowdish, Dawn M. E. Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections |
title | Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections |
title_full | Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections |
title_fullStr | Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections |
title_full_unstemmed | Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections |
title_short | Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections |
title_sort | lasting changes to circulating leukocytes in people with mild sars-cov-2 infections |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622816/ https://www.ncbi.nlm.nih.gov/pubmed/34835045 http://dx.doi.org/10.3390/v13112239 |
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