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Length of Nutritional Transition Associates Negatively with Postnatal Growth in Very Low Birthweight Infants

Very low birthweight (VLBW, <1500 g) infants may be predisposed to undernutrition during the nutritional transition phase from parenteral to enteral nutrition. We studied the associations among the length of the transition phase, postnatal macronutrient intake, and growth from birth to term equiv...

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Autores principales: Immeli, Lotta, Sankilampi, Ulla, Mäkelä, Pauliina M., Leskinen, Markus, Sund, Reijo, Andersson, Sture, Luukkainen, Päivi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622897/
https://www.ncbi.nlm.nih.gov/pubmed/34836216
http://dx.doi.org/10.3390/nu13113961
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author Immeli, Lotta
Sankilampi, Ulla
Mäkelä, Pauliina M.
Leskinen, Markus
Sund, Reijo
Andersson, Sture
Luukkainen, Päivi
author_facet Immeli, Lotta
Sankilampi, Ulla
Mäkelä, Pauliina M.
Leskinen, Markus
Sund, Reijo
Andersson, Sture
Luukkainen, Päivi
author_sort Immeli, Lotta
collection PubMed
description Very low birthweight (VLBW, <1500 g) infants may be predisposed to undernutrition during the nutritional transition phase from parenteral to enteral nutrition. We studied the associations among the length of the transition phase, postnatal macronutrient intake, and growth from birth to term equivalent age in VLBW infants. This retrospective cohort study included 248 VLBW infants born before 32 weeks of gestation and admitted to the Children’s Hospital, Helsinki, Finland during 2005–2013. Daily nutrient intakes were obtained from computerized medication administration records. The length of the transition phase correlated negatively with cumulative energy, protein, fat, and carbohydrate intake at 28 days of age. It also associated negatively with weight and head circumference growth from birth to term equivalent age. For infants with a long transition phase (over 12 d), the estimates (95% CI) for weight and head circumference z-score change from birth to term equivalent age were −0.3 (−0.56, −0.04) and −0.44 (−0.81, −0.07), respectively, in comparison to those with a short transition phase (ad 7 d). For VLBW infants, rapid transition to full enteral feeding might be beneficial. However, if enteral nutrition cannot be advanced, well-planned parenteral nutrition during the transition phase is necessary to promote adequate growth.
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spelling pubmed-86228972021-11-27 Length of Nutritional Transition Associates Negatively with Postnatal Growth in Very Low Birthweight Infants Immeli, Lotta Sankilampi, Ulla Mäkelä, Pauliina M. Leskinen, Markus Sund, Reijo Andersson, Sture Luukkainen, Päivi Nutrients Article Very low birthweight (VLBW, <1500 g) infants may be predisposed to undernutrition during the nutritional transition phase from parenteral to enteral nutrition. We studied the associations among the length of the transition phase, postnatal macronutrient intake, and growth from birth to term equivalent age in VLBW infants. This retrospective cohort study included 248 VLBW infants born before 32 weeks of gestation and admitted to the Children’s Hospital, Helsinki, Finland during 2005–2013. Daily nutrient intakes were obtained from computerized medication administration records. The length of the transition phase correlated negatively with cumulative energy, protein, fat, and carbohydrate intake at 28 days of age. It also associated negatively with weight and head circumference growth from birth to term equivalent age. For infants with a long transition phase (over 12 d), the estimates (95% CI) for weight and head circumference z-score change from birth to term equivalent age were −0.3 (−0.56, −0.04) and −0.44 (−0.81, −0.07), respectively, in comparison to those with a short transition phase (ad 7 d). For VLBW infants, rapid transition to full enteral feeding might be beneficial. However, if enteral nutrition cannot be advanced, well-planned parenteral nutrition during the transition phase is necessary to promote adequate growth. MDPI 2021-11-06 /pmc/articles/PMC8622897/ /pubmed/34836216 http://dx.doi.org/10.3390/nu13113961 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Immeli, Lotta
Sankilampi, Ulla
Mäkelä, Pauliina M.
Leskinen, Markus
Sund, Reijo
Andersson, Sture
Luukkainen, Päivi
Length of Nutritional Transition Associates Negatively with Postnatal Growth in Very Low Birthweight Infants
title Length of Nutritional Transition Associates Negatively with Postnatal Growth in Very Low Birthweight Infants
title_full Length of Nutritional Transition Associates Negatively with Postnatal Growth in Very Low Birthweight Infants
title_fullStr Length of Nutritional Transition Associates Negatively with Postnatal Growth in Very Low Birthweight Infants
title_full_unstemmed Length of Nutritional Transition Associates Negatively with Postnatal Growth in Very Low Birthweight Infants
title_short Length of Nutritional Transition Associates Negatively with Postnatal Growth in Very Low Birthweight Infants
title_sort length of nutritional transition associates negatively with postnatal growth in very low birthweight infants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622897/
https://www.ncbi.nlm.nih.gov/pubmed/34836216
http://dx.doi.org/10.3390/nu13113961
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