Simultaneous Quantification of Propylthiouracil and Its N-β-d Glucuronide by HPLC-MS/MS: Application to a Metabolic Study

Propylthiouracil (PTU) is commonly prescribed for the management of hyperthyroidism and thyrotoxicosis. Although the exact mechanism of action is not fully understood, PTU is associated with hepatoxicity in pediatric population. Glucuronidation mediated by uridine 5′-diphospho-glucuronosyltransferas...

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Detalles Bibliográficos
Autores principales: Li, Min, He, Qingfeng, Yao, Li, Wang, Xiaofeng, Tang, Zhijia, Zhu, Xiao, Lin, Hai-Shu, Xiang, Xiaoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622909/
https://www.ncbi.nlm.nih.gov/pubmed/34832976
http://dx.doi.org/10.3390/ph14111194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622909/
https://www.ncbi.nlm.nih.gov/pubmed/34832976
http://dx.doi.org/10.3390/ph14111194

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