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The Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status
Osteoarthritis (OA) is a common joint condition and one of the greatest causes of disability worldwide. The role of vitamin D in the origin and development of the disease is not clear, although it could have important implications for diagnosis and treatment. For this proposal, a cross-sectional stu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622912/ https://www.ncbi.nlm.nih.gov/pubmed/34836290 http://dx.doi.org/10.3390/nu13114035 |
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author | Alabajos-Cea, Ana Herrero-Manley, Luz Suso-Martí, Luis Viosca-Herrero, Enrique Cuenca-Martínez, Ferran Varangot-Reille, Clovis Blanco-Díaz, María Calatayud, Joaquín Casaña, José |
author_facet | Alabajos-Cea, Ana Herrero-Manley, Luz Suso-Martí, Luis Viosca-Herrero, Enrique Cuenca-Martínez, Ferran Varangot-Reille, Clovis Blanco-Díaz, María Calatayud, Joaquín Casaña, José |
author_sort | Alabajos-Cea, Ana |
collection | PubMed |
description | Osteoarthritis (OA) is a common joint condition and one of the greatest causes of disability worldwide. The role of vitamin D in the origin and development of the disease is not clear, although it could have important implications for diagnosis and treatment. For this proposal, a cross-sectional study with a non-probabilistic sample was performed. In total, 48 with early osteoarthritis (EOA) and 48 matched controls were selected, and serum 25(OH)D and parathyroid hormone (PTH) levels were analyzed. In addition, physical and psychological variables were measured to establish their relationship with vitamin D levels. Patients with EOA showed lower levels (22.3 ± 7.3 ng/mL) in comparison to matched controls (29.31 ± 9.2 ng/mL). A statistically significant higher number (Chi-squared = 8.525; p = 0.004) of patients with EOA had deficiency levels (<20 ng/mL) compared to the control group. Patients with lower vitamin D levels showed higher levels of pain intensity, disability, and anxiety, as well as poorer values for sit-to-stand, walking speed, and social participation. Correlation analysis showed a relationship between serum 25(OH)D, PTH and pain intensity, and social participation. These results highlight the relevance of vitamin D in the early diagnosis and prevention of EOA. |
format | Online Article Text |
id | pubmed-8622912 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86229122021-11-27 The Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status Alabajos-Cea, Ana Herrero-Manley, Luz Suso-Martí, Luis Viosca-Herrero, Enrique Cuenca-Martínez, Ferran Varangot-Reille, Clovis Blanco-Díaz, María Calatayud, Joaquín Casaña, José Nutrients Article Osteoarthritis (OA) is a common joint condition and one of the greatest causes of disability worldwide. The role of vitamin D in the origin and development of the disease is not clear, although it could have important implications for diagnosis and treatment. For this proposal, a cross-sectional study with a non-probabilistic sample was performed. In total, 48 with early osteoarthritis (EOA) and 48 matched controls were selected, and serum 25(OH)D and parathyroid hormone (PTH) levels were analyzed. In addition, physical and psychological variables were measured to establish their relationship with vitamin D levels. Patients with EOA showed lower levels (22.3 ± 7.3 ng/mL) in comparison to matched controls (29.31 ± 9.2 ng/mL). A statistically significant higher number (Chi-squared = 8.525; p = 0.004) of patients with EOA had deficiency levels (<20 ng/mL) compared to the control group. Patients with lower vitamin D levels showed higher levels of pain intensity, disability, and anxiety, as well as poorer values for sit-to-stand, walking speed, and social participation. Correlation analysis showed a relationship between serum 25(OH)D, PTH and pain intensity, and social participation. These results highlight the relevance of vitamin D in the early diagnosis and prevention of EOA. MDPI 2021-11-12 /pmc/articles/PMC8622912/ /pubmed/34836290 http://dx.doi.org/10.3390/nu13114035 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alabajos-Cea, Ana Herrero-Manley, Luz Suso-Martí, Luis Viosca-Herrero, Enrique Cuenca-Martínez, Ferran Varangot-Reille, Clovis Blanco-Díaz, María Calatayud, Joaquín Casaña, José The Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status |
title | The Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status |
title_full | The Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status |
title_fullStr | The Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status |
title_full_unstemmed | The Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status |
title_short | The Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status |
title_sort | role of vitamin d in early knee osteoarthritis and its relationship with their physical and psychological status |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622912/ https://www.ncbi.nlm.nih.gov/pubmed/34836290 http://dx.doi.org/10.3390/nu13114035 |
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