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Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview

Respiratory viruses represent a major public health concern, as they are highly mutated, resulting in new strains emerging with high pathogenicity. Currently, the world is suffering from the newly evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus is the cause of coron...

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Autores principales: Al-Karmalawy, Ahmed A., Soltane, Raya, Abo Elmaaty, Ayman, Tantawy, Mohamed A., Antar, Samar A., Yahya, Galal, Chrouda, Amani, Pashameah, Rami Adel, Mustafa, Muhamad, Abu Mraheil, Mobarak, Mostafa, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622998/
https://www.ncbi.nlm.nih.gov/pubmed/34835248
http://dx.doi.org/10.3390/vaccines9111317
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author Al-Karmalawy, Ahmed A.
Soltane, Raya
Abo Elmaaty, Ayman
Tantawy, Mohamed A.
Antar, Samar A.
Yahya, Galal
Chrouda, Amani
Pashameah, Rami Adel
Mustafa, Muhamad
Abu Mraheil, Mobarak
Mostafa, Ahmed
author_facet Al-Karmalawy, Ahmed A.
Soltane, Raya
Abo Elmaaty, Ayman
Tantawy, Mohamed A.
Antar, Samar A.
Yahya, Galal
Chrouda, Amani
Pashameah, Rami Adel
Mustafa, Muhamad
Abu Mraheil, Mobarak
Mostafa, Ahmed
author_sort Al-Karmalawy, Ahmed A.
collection PubMed
description Respiratory viruses represent a major public health concern, as they are highly mutated, resulting in new strains emerging with high pathogenicity. Currently, the world is suffering from the newly evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus is the cause of coronavirus disease 2019 (COVID-19), a mild-to-severe respiratory tract infection with frequent ability to give rise to fatal pneumonia in humans. The overwhelming outbreak of SARS-CoV-2 continues to unfold all over the world, urging scientists to put an end to this global pandemic through biological and pharmaceutical interventions. Currently, there is no specific treatment option that is capable of COVID-19 pandemic eradication, so several repurposed drugs and newly conditionally approved vaccines are in use and heavily applied to control the COVID-19 pandemic. The emergence of new variants of the virus that partially or totally escape from the immune response elicited by the approved vaccines requires continuous monitoring of the emerging variants to update the content of the developed vaccines or modify them totally to match the new variants. Herein, we discuss the potential therapeutic and prophylactic interventions including repurposed drugs and the newly developed/approved vaccines, highlighting the impact of virus evolution on the immune evasion of the virus from currently licensed vaccines for COVID-19.
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spelling pubmed-86229982021-11-27 Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview Al-Karmalawy, Ahmed A. Soltane, Raya Abo Elmaaty, Ayman Tantawy, Mohamed A. Antar, Samar A. Yahya, Galal Chrouda, Amani Pashameah, Rami Adel Mustafa, Muhamad Abu Mraheil, Mobarak Mostafa, Ahmed Vaccines (Basel) Review Respiratory viruses represent a major public health concern, as they are highly mutated, resulting in new strains emerging with high pathogenicity. Currently, the world is suffering from the newly evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus is the cause of coronavirus disease 2019 (COVID-19), a mild-to-severe respiratory tract infection with frequent ability to give rise to fatal pneumonia in humans. The overwhelming outbreak of SARS-CoV-2 continues to unfold all over the world, urging scientists to put an end to this global pandemic through biological and pharmaceutical interventions. Currently, there is no specific treatment option that is capable of COVID-19 pandemic eradication, so several repurposed drugs and newly conditionally approved vaccines are in use and heavily applied to control the COVID-19 pandemic. The emergence of new variants of the virus that partially or totally escape from the immune response elicited by the approved vaccines requires continuous monitoring of the emerging variants to update the content of the developed vaccines or modify them totally to match the new variants. Herein, we discuss the potential therapeutic and prophylactic interventions including repurposed drugs and the newly developed/approved vaccines, highlighting the impact of virus evolution on the immune evasion of the virus from currently licensed vaccines for COVID-19. MDPI 2021-11-12 /pmc/articles/PMC8622998/ /pubmed/34835248 http://dx.doi.org/10.3390/vaccines9111317 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Al-Karmalawy, Ahmed A.
Soltane, Raya
Abo Elmaaty, Ayman
Tantawy, Mohamed A.
Antar, Samar A.
Yahya, Galal
Chrouda, Amani
Pashameah, Rami Adel
Mustafa, Muhamad
Abu Mraheil, Mobarak
Mostafa, Ahmed
Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview
title Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview
title_full Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview
title_fullStr Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview
title_full_unstemmed Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview
title_short Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview
title_sort coronavirus disease (covid-19) control between drug repurposing and vaccination: a comprehensive overview
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622998/
https://www.ncbi.nlm.nih.gov/pubmed/34835248
http://dx.doi.org/10.3390/vaccines9111317
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