Early Intervention and Lifelong Treatment with GLP1 Receptor Agonist Liraglutide in a Wolfram Syndrome Rat Model with an Emphasis on Visual Neurodegeneration, Sensorineural Hearing Loss and Diabetic Phenotype

Wolfram syndrome (WS), also known as a DIDMOAD (diabetes insipidus, early-onset diabetes mellitus, optic nerve atrophy and deafness) is a rare autosomal disorder caused by mutations in the Wolframin1 (WFS1) gene. Previous studies have revealed that glucagon-like peptide-1 receptor agonist (GLP1 RA)...

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Detalles Bibliográficos
Autores principales: Jagomäe, Toomas, Seppa, Kadri, Reimets, Riin, Pastak, Marko, Plaas, Mihkel, Hickey, Miriam A., Kukker, Kaia Grete, Moons, Lieve, De Groef, Lies, Vasar, Eero, Kaasik, Allen, Terasmaa, Anton, Plaas, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623088/
https://www.ncbi.nlm.nih.gov/pubmed/34831417
http://dx.doi.org/10.3390/cells10113193

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