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Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi
Effective management and treatment of fungal diseases is hampered by poor diagnosis, limited options for antifungal therapy, and the emergence of antifungal drug resistance. An understanding of molecular mechanisms contributing to resistance is essential to optimize the efficacy of currently availab...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623157/ https://www.ncbi.nlm.nih.gov/pubmed/34829198 http://dx.doi.org/10.3390/jof7110909 |
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author | Delma, Fatima Zohra Al-Hatmi, Abdullah M. S. Brüggemann, Roger J. M. Melchers, Willem J. G. de Hoog, Sybren Verweij, Paul E. Buil, Jochem B. |
author_facet | Delma, Fatima Zohra Al-Hatmi, Abdullah M. S. Brüggemann, Roger J. M. Melchers, Willem J. G. de Hoog, Sybren Verweij, Paul E. Buil, Jochem B. |
author_sort | Delma, Fatima Zohra |
collection | PubMed |
description | Effective management and treatment of fungal diseases is hampered by poor diagnosis, limited options for antifungal therapy, and the emergence of antifungal drug resistance. An understanding of molecular mechanisms contributing to resistance is essential to optimize the efficacy of currently available antifungals. In this perspective, one of the oldest antifungals, 5-fluorocytosine (5-FC), has been the focus of recent studies applying advanced genomic and transcriptomic techniques to decipher the order of events at the molecular level that lead to resistance. These studies have highlighted the complexity of resistance and provided new insights that are reviewed in the present paper. |
format | Online Article Text |
id | pubmed-8623157 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86231572021-11-27 Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi Delma, Fatima Zohra Al-Hatmi, Abdullah M. S. Brüggemann, Roger J. M. Melchers, Willem J. G. de Hoog, Sybren Verweij, Paul E. Buil, Jochem B. J Fungi (Basel) Review Effective management and treatment of fungal diseases is hampered by poor diagnosis, limited options for antifungal therapy, and the emergence of antifungal drug resistance. An understanding of molecular mechanisms contributing to resistance is essential to optimize the efficacy of currently available antifungals. In this perspective, one of the oldest antifungals, 5-fluorocytosine (5-FC), has been the focus of recent studies applying advanced genomic and transcriptomic techniques to decipher the order of events at the molecular level that lead to resistance. These studies have highlighted the complexity of resistance and provided new insights that are reviewed in the present paper. MDPI 2021-10-27 /pmc/articles/PMC8623157/ /pubmed/34829198 http://dx.doi.org/10.3390/jof7110909 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Delma, Fatima Zohra Al-Hatmi, Abdullah M. S. Brüggemann, Roger J. M. Melchers, Willem J. G. de Hoog, Sybren Verweij, Paul E. Buil, Jochem B. Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi |
title | Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi |
title_full | Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi |
title_fullStr | Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi |
title_full_unstemmed | Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi |
title_short | Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi |
title_sort | molecular mechanisms of 5-fluorocytosine resistance in yeasts and filamentous fungi |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623157/ https://www.ncbi.nlm.nih.gov/pubmed/34829198 http://dx.doi.org/10.3390/jof7110909 |
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