Cargando…
High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2
Background: Since the beginning of the COVID-19 pandemic, several SARS-CoV-2 variants have sequentially emerged. In France, most cases were due to spike D641G-harbouring viruses that descended initially from the Wuhan strain, then by the variant of B.1.160 lineage we called Marseille-4 since the sum...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623169/ https://www.ncbi.nlm.nih.gov/pubmed/34834983 http://dx.doi.org/10.3390/v13112177 |
_version_ | 1784605867346231296 |
---|---|
author | Jaafar, Rita Boschi, Celine Aherfi, Sarah Bancod, Audrey Le Bideau, Marion Edouard, Sophie Colson, Philippe Chahinian, Henri Raoult, Didier Yahi, Nouara Fantini, Jacques La Scola, Bernard |
author_facet | Jaafar, Rita Boschi, Celine Aherfi, Sarah Bancod, Audrey Le Bideau, Marion Edouard, Sophie Colson, Philippe Chahinian, Henri Raoult, Didier Yahi, Nouara Fantini, Jacques La Scola, Bernard |
author_sort | Jaafar, Rita |
collection | PubMed |
description | Background: Since the beginning of the COVID-19 pandemic, several SARS-CoV-2 variants have sequentially emerged. In France, most cases were due to spike D641G-harbouring viruses that descended initially from the Wuhan strain, then by the variant of B.1.160 lineage we called Marseille-4 since the summer of 2020, which was followed by the Alpha and Beta variants in early 2021, then the Delta variant currently. Methods: We determined the neutralising antibody (nAb) titres in sera from convalescent individuals previously infected by these four major local variants and from vaccine recipients to the original Wuhan strain and nine variants, including two recent circulating Delta isolates. Results: The results show high inter-individual heterogeneity in nAbs, especially according to the variant tested. The major variations among nAbs are based on the genotype responsible for the infection. Patients previously infected with the beta and B.1.160 variants had the lowest nAb titres. We show that this heterogeneity is well explained by spike protein mutants modelling using in silico approaches. The highest titres were observed in individuals vaccinated with the Pfizer/BioNTech COVID-19 vaccine, even against the delta variant. Conclusions: Immunity acquired naturally after infection is highly dependent on the infecting variant, and, unexpectedly, mRNA-based vaccine efficacy was shown to be often better than natural immunity in eliciting neutralising antibodies. |
format | Online Article Text |
id | pubmed-8623169 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86231692021-11-27 High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2 Jaafar, Rita Boschi, Celine Aherfi, Sarah Bancod, Audrey Le Bideau, Marion Edouard, Sophie Colson, Philippe Chahinian, Henri Raoult, Didier Yahi, Nouara Fantini, Jacques La Scola, Bernard Viruses Article Background: Since the beginning of the COVID-19 pandemic, several SARS-CoV-2 variants have sequentially emerged. In France, most cases were due to spike D641G-harbouring viruses that descended initially from the Wuhan strain, then by the variant of B.1.160 lineage we called Marseille-4 since the summer of 2020, which was followed by the Alpha and Beta variants in early 2021, then the Delta variant currently. Methods: We determined the neutralising antibody (nAb) titres in sera from convalescent individuals previously infected by these four major local variants and from vaccine recipients to the original Wuhan strain and nine variants, including two recent circulating Delta isolates. Results: The results show high inter-individual heterogeneity in nAbs, especially according to the variant tested. The major variations among nAbs are based on the genotype responsible for the infection. Patients previously infected with the beta and B.1.160 variants had the lowest nAb titres. We show that this heterogeneity is well explained by spike protein mutants modelling using in silico approaches. The highest titres were observed in individuals vaccinated with the Pfizer/BioNTech COVID-19 vaccine, even against the delta variant. Conclusions: Immunity acquired naturally after infection is highly dependent on the infecting variant, and, unexpectedly, mRNA-based vaccine efficacy was shown to be often better than natural immunity in eliciting neutralising antibodies. MDPI 2021-10-28 /pmc/articles/PMC8623169/ /pubmed/34834983 http://dx.doi.org/10.3390/v13112177 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jaafar, Rita Boschi, Celine Aherfi, Sarah Bancod, Audrey Le Bideau, Marion Edouard, Sophie Colson, Philippe Chahinian, Henri Raoult, Didier Yahi, Nouara Fantini, Jacques La Scola, Bernard High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2 |
title | High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2 |
title_full | High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2 |
title_fullStr | High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2 |
title_full_unstemmed | High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2 |
title_short | High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2 |
title_sort | high individual heterogeneity of neutralizing activities against the original strain and nine different variants of sars-cov-2 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623169/ https://www.ncbi.nlm.nih.gov/pubmed/34834983 http://dx.doi.org/10.3390/v13112177 |
work_keys_str_mv | AT jaafarrita highindividualheterogeneityofneutralizingactivitiesagainsttheoriginalstrainandninedifferentvariantsofsarscov2 AT boschiceline highindividualheterogeneityofneutralizingactivitiesagainsttheoriginalstrainandninedifferentvariantsofsarscov2 AT aherfisarah highindividualheterogeneityofneutralizingactivitiesagainsttheoriginalstrainandninedifferentvariantsofsarscov2 AT bancodaudrey highindividualheterogeneityofneutralizingactivitiesagainsttheoriginalstrainandninedifferentvariantsofsarscov2 AT lebideaumarion highindividualheterogeneityofneutralizingactivitiesagainsttheoriginalstrainandninedifferentvariantsofsarscov2 AT edouardsophie highindividualheterogeneityofneutralizingactivitiesagainsttheoriginalstrainandninedifferentvariantsofsarscov2 AT colsonphilippe highindividualheterogeneityofneutralizingactivitiesagainsttheoriginalstrainandninedifferentvariantsofsarscov2 AT chahinianhenri highindividualheterogeneityofneutralizingactivitiesagainsttheoriginalstrainandninedifferentvariantsofsarscov2 AT raoultdidier highindividualheterogeneityofneutralizingactivitiesagainsttheoriginalstrainandninedifferentvariantsofsarscov2 AT yahinouara highindividualheterogeneityofneutralizingactivitiesagainsttheoriginalstrainandninedifferentvariantsofsarscov2 AT fantinijacques highindividualheterogeneityofneutralizingactivitiesagainsttheoriginalstrainandninedifferentvariantsofsarscov2 AT lascolabernard highindividualheterogeneityofneutralizingactivitiesagainsttheoriginalstrainandninedifferentvariantsofsarscov2 |