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Staphylococcal Scalded Skin Syndrome and Bullous Impetigo

Staphylococcal scalded skin syndrome (SSSS) and bullous impetigo are infections caused by Staphylococcus aureus. The pathogenesis of both conditions centers around exotoxin mediated cleavage of desmoglein-1, which results in intraepidermal desquamation. Bullous impetigo is due to the local release o...

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Detalles Bibliográficos
Autores principales: Brazel, Morgan, Desai, Anand, Are, Abhirup, Motaparthi, Kiran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623226/
https://www.ncbi.nlm.nih.gov/pubmed/34833375
http://dx.doi.org/10.3390/medicina57111157
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author Brazel, Morgan
Desai, Anand
Are, Abhirup
Motaparthi, Kiran
author_facet Brazel, Morgan
Desai, Anand
Are, Abhirup
Motaparthi, Kiran
author_sort Brazel, Morgan
collection PubMed
description Staphylococcal scalded skin syndrome (SSSS) and bullous impetigo are infections caused by Staphylococcus aureus. The pathogenesis of both conditions centers around exotoxin mediated cleavage of desmoglein-1, which results in intraepidermal desquamation. Bullous impetigo is due to the local release of these toxins and thus, often presents with localized skin findings, whereas SSSS is from the systemic spread of these toxins, resulting in a more generalized rash and severe presentation. Both conditions are treated with antibiotics that target S. aureus. These conditions can sometimes be confused with other conditions that result in superficial blistering; the distinguishing features are outlined below.
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spelling pubmed-86232262021-11-27 Staphylococcal Scalded Skin Syndrome and Bullous Impetigo Brazel, Morgan Desai, Anand Are, Abhirup Motaparthi, Kiran Medicina (Kaunas) Review Staphylococcal scalded skin syndrome (SSSS) and bullous impetigo are infections caused by Staphylococcus aureus. The pathogenesis of both conditions centers around exotoxin mediated cleavage of desmoglein-1, which results in intraepidermal desquamation. Bullous impetigo is due to the local release of these toxins and thus, often presents with localized skin findings, whereas SSSS is from the systemic spread of these toxins, resulting in a more generalized rash and severe presentation. Both conditions are treated with antibiotics that target S. aureus. These conditions can sometimes be confused with other conditions that result in superficial blistering; the distinguishing features are outlined below. MDPI 2021-10-24 /pmc/articles/PMC8623226/ /pubmed/34833375 http://dx.doi.org/10.3390/medicina57111157 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Brazel, Morgan
Desai, Anand
Are, Abhirup
Motaparthi, Kiran
Staphylococcal Scalded Skin Syndrome and Bullous Impetigo
title Staphylococcal Scalded Skin Syndrome and Bullous Impetigo
title_full Staphylococcal Scalded Skin Syndrome and Bullous Impetigo
title_fullStr Staphylococcal Scalded Skin Syndrome and Bullous Impetigo
title_full_unstemmed Staphylococcal Scalded Skin Syndrome and Bullous Impetigo
title_short Staphylococcal Scalded Skin Syndrome and Bullous Impetigo
title_sort staphylococcal scalded skin syndrome and bullous impetigo
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623226/
https://www.ncbi.nlm.nih.gov/pubmed/34833375
http://dx.doi.org/10.3390/medicina57111157
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