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Baseline Drug Treatments as Indicators of Increased Risk of COVID-19 Mortality in Spain and Italy

This study aims to identify baseline medications that, as a proxy for the diseases they are dispensed for, are associated with increased risk of mortality in COVID-19 patients from two regions in Spain and Italy using real-world data. We conducted a cross-country, retrospective, observational study...

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Autores principales: Bliek-Bueno, Kevin, Mucherino, Sara, Poblador-Plou, Beatriz, González-Rubio, Francisca, Aza-Pascual-Salcedo, Mercedes, Orlando, Valentina, Clerencia-Sierra, Mercedes, Ioakeim-Skoufa, Ignatios, Coscioni, Enrico, Carmona-Pírez, Jonás, Perrella, Alessandro, Trama, Ugo, Prados-Torres, Alexandra, Menditto, Enrica, Gimeno-Miguel, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623536/
https://www.ncbi.nlm.nih.gov/pubmed/34831541
http://dx.doi.org/10.3390/ijerph182211786
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author Bliek-Bueno, Kevin
Mucherino, Sara
Poblador-Plou, Beatriz
González-Rubio, Francisca
Aza-Pascual-Salcedo, Mercedes
Orlando, Valentina
Clerencia-Sierra, Mercedes
Ioakeim-Skoufa, Ignatios
Coscioni, Enrico
Carmona-Pírez, Jonás
Perrella, Alessandro
Trama, Ugo
Prados-Torres, Alexandra
Menditto, Enrica
Gimeno-Miguel, Antonio
author_facet Bliek-Bueno, Kevin
Mucherino, Sara
Poblador-Plou, Beatriz
González-Rubio, Francisca
Aza-Pascual-Salcedo, Mercedes
Orlando, Valentina
Clerencia-Sierra, Mercedes
Ioakeim-Skoufa, Ignatios
Coscioni, Enrico
Carmona-Pírez, Jonás
Perrella, Alessandro
Trama, Ugo
Prados-Torres, Alexandra
Menditto, Enrica
Gimeno-Miguel, Antonio
author_sort Bliek-Bueno, Kevin
collection PubMed
description This study aims to identify baseline medications that, as a proxy for the diseases they are dispensed for, are associated with increased risk of mortality in COVID-19 patients from two regions in Spain and Italy using real-world data. We conducted a cross-country, retrospective, observational study including 8570 individuals from both regions with confirmed SARS-CoV-2 infection between 4 March and 17 April 2020, and followed them for a minimum of 30 days to allow sufficient time for the studied event, in this case death, to occur. Baseline demographic variables and all drugs dispensed in community pharmacies three months prior to infection were extracted from the PRECOVID Study cohort (Aragon, Spain) and the Campania Region Database (Campania, Italy) and analyzed using logistic regression models. Results show that the presence at baseline of potassium-sparing agents, antipsychotics, vasodilators, high-ceiling diuretics, antithrombotic agents, vitamin B12, folic acid, and antiepileptics were systematically associated with mortality in COVID-19 patients from both countries. Treatments for chronic cardiovascular and metabolic diseases, systemic inflammation, and processes with increased risk of thrombosis as proxies for the conditions they are intended for can serve as timely indicators of an increased likelihood of mortality after the infection, and the assessment of pharmacological profiles can be an additional approach to the identification of at-risk individuals in clinical practice.
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spelling pubmed-86235362021-11-27 Baseline Drug Treatments as Indicators of Increased Risk of COVID-19 Mortality in Spain and Italy Bliek-Bueno, Kevin Mucherino, Sara Poblador-Plou, Beatriz González-Rubio, Francisca Aza-Pascual-Salcedo, Mercedes Orlando, Valentina Clerencia-Sierra, Mercedes Ioakeim-Skoufa, Ignatios Coscioni, Enrico Carmona-Pírez, Jonás Perrella, Alessandro Trama, Ugo Prados-Torres, Alexandra Menditto, Enrica Gimeno-Miguel, Antonio Int J Environ Res Public Health Article This study aims to identify baseline medications that, as a proxy for the diseases they are dispensed for, are associated with increased risk of mortality in COVID-19 patients from two regions in Spain and Italy using real-world data. We conducted a cross-country, retrospective, observational study including 8570 individuals from both regions with confirmed SARS-CoV-2 infection between 4 March and 17 April 2020, and followed them for a minimum of 30 days to allow sufficient time for the studied event, in this case death, to occur. Baseline demographic variables and all drugs dispensed in community pharmacies three months prior to infection were extracted from the PRECOVID Study cohort (Aragon, Spain) and the Campania Region Database (Campania, Italy) and analyzed using logistic regression models. Results show that the presence at baseline of potassium-sparing agents, antipsychotics, vasodilators, high-ceiling diuretics, antithrombotic agents, vitamin B12, folic acid, and antiepileptics were systematically associated with mortality in COVID-19 patients from both countries. Treatments for chronic cardiovascular and metabolic diseases, systemic inflammation, and processes with increased risk of thrombosis as proxies for the conditions they are intended for can serve as timely indicators of an increased likelihood of mortality after the infection, and the assessment of pharmacological profiles can be an additional approach to the identification of at-risk individuals in clinical practice. MDPI 2021-11-10 /pmc/articles/PMC8623536/ /pubmed/34831541 http://dx.doi.org/10.3390/ijerph182211786 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bliek-Bueno, Kevin
Mucherino, Sara
Poblador-Plou, Beatriz
González-Rubio, Francisca
Aza-Pascual-Salcedo, Mercedes
Orlando, Valentina
Clerencia-Sierra, Mercedes
Ioakeim-Skoufa, Ignatios
Coscioni, Enrico
Carmona-Pírez, Jonás
Perrella, Alessandro
Trama, Ugo
Prados-Torres, Alexandra
Menditto, Enrica
Gimeno-Miguel, Antonio
Baseline Drug Treatments as Indicators of Increased Risk of COVID-19 Mortality in Spain and Italy
title Baseline Drug Treatments as Indicators of Increased Risk of COVID-19 Mortality in Spain and Italy
title_full Baseline Drug Treatments as Indicators of Increased Risk of COVID-19 Mortality in Spain and Italy
title_fullStr Baseline Drug Treatments as Indicators of Increased Risk of COVID-19 Mortality in Spain and Italy
title_full_unstemmed Baseline Drug Treatments as Indicators of Increased Risk of COVID-19 Mortality in Spain and Italy
title_short Baseline Drug Treatments as Indicators of Increased Risk of COVID-19 Mortality in Spain and Italy
title_sort baseline drug treatments as indicators of increased risk of covid-19 mortality in spain and italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623536/
https://www.ncbi.nlm.nih.gov/pubmed/34831541
http://dx.doi.org/10.3390/ijerph182211786
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