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A Blueprint for Cancer-Related Inflammation and Host Innate Immunity

Both in situ and allograft models of cancer in juvenile and adult Drosophila melanogaster fruit flies offer a powerful means for unravelling cancer gene networks and cancer–host interactions. They can also be used as tools for cost-effective drug discovery and repurposing. Moreover, in situ modeling...

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Autores principales: García-López, Lucia, Adrados, Isabel, Ferres-Marco, Dolors, Dominguez, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623541/
https://www.ncbi.nlm.nih.gov/pubmed/34831432
http://dx.doi.org/10.3390/cells10113211
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author García-López, Lucia
Adrados, Isabel
Ferres-Marco, Dolors
Dominguez, Maria
author_facet García-López, Lucia
Adrados, Isabel
Ferres-Marco, Dolors
Dominguez, Maria
author_sort García-López, Lucia
collection PubMed
description Both in situ and allograft models of cancer in juvenile and adult Drosophila melanogaster fruit flies offer a powerful means for unravelling cancer gene networks and cancer–host interactions. They can also be used as tools for cost-effective drug discovery and repurposing. Moreover, in situ modeling of emerging tumors makes it possible to address cancer initiating events—a black box in cancer research, tackle the innate antitumor immune responses to incipient preneoplastic cells and recurrent growing tumors, and decipher the initiation and evolution of inflammation. These studies in Drosophila melanogaster can serve as a blueprint for studies in more complex organisms and help in the design of mechanism-based therapies for the individualized treatment of cancer diseases in humans. This review focuses on new discoveries in Drosophila related to the diverse innate immune responses to cancer-related inflammation and the systemic effects that are so detrimental to the host.
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spelling pubmed-86235412021-11-27 A Blueprint for Cancer-Related Inflammation and Host Innate Immunity García-López, Lucia Adrados, Isabel Ferres-Marco, Dolors Dominguez, Maria Cells Review Both in situ and allograft models of cancer in juvenile and adult Drosophila melanogaster fruit flies offer a powerful means for unravelling cancer gene networks and cancer–host interactions. They can also be used as tools for cost-effective drug discovery and repurposing. Moreover, in situ modeling of emerging tumors makes it possible to address cancer initiating events—a black box in cancer research, tackle the innate antitumor immune responses to incipient preneoplastic cells and recurrent growing tumors, and decipher the initiation and evolution of inflammation. These studies in Drosophila melanogaster can serve as a blueprint for studies in more complex organisms and help in the design of mechanism-based therapies for the individualized treatment of cancer diseases in humans. This review focuses on new discoveries in Drosophila related to the diverse innate immune responses to cancer-related inflammation and the systemic effects that are so detrimental to the host. MDPI 2021-11-17 /pmc/articles/PMC8623541/ /pubmed/34831432 http://dx.doi.org/10.3390/cells10113211 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
García-López, Lucia
Adrados, Isabel
Ferres-Marco, Dolors
Dominguez, Maria
A Blueprint for Cancer-Related Inflammation and Host Innate Immunity
title A Blueprint for Cancer-Related Inflammation and Host Innate Immunity
title_full A Blueprint for Cancer-Related Inflammation and Host Innate Immunity
title_fullStr A Blueprint for Cancer-Related Inflammation and Host Innate Immunity
title_full_unstemmed A Blueprint for Cancer-Related Inflammation and Host Innate Immunity
title_short A Blueprint for Cancer-Related Inflammation and Host Innate Immunity
title_sort blueprint for cancer-related inflammation and host innate immunity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623541/
https://www.ncbi.nlm.nih.gov/pubmed/34831432
http://dx.doi.org/10.3390/cells10113211
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