Cargando…

Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus

The purpose of the study was to determine the influence of lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) values on the prognosis in patients with renal cell carcinoma (RCC) and venous tumor thrombus. The respective data of 91 patient...

Descripción completa

Detalles Bibliográficos
Autores principales: Zapała, Łukasz, Kunc, Michał, Sharma, Sumit, Biernat, Wojciech, Radziszewski, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623560/
https://www.ncbi.nlm.nih.gov/pubmed/34829506
http://dx.doi.org/10.3390/diagnostics11112159
_version_ 1784605961938272256
author Zapała, Łukasz
Kunc, Michał
Sharma, Sumit
Biernat, Wojciech
Radziszewski, Piotr
author_facet Zapała, Łukasz
Kunc, Michał
Sharma, Sumit
Biernat, Wojciech
Radziszewski, Piotr
author_sort Zapała, Łukasz
collection PubMed
description The purpose of the study was to determine the influence of lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) values on the prognosis in patients with renal cell carcinoma (RCC) and venous tumor thrombus. The respective data of 91 patients treated with radical surgery in the years 2012–2021 in 2 tertiary referral urological centers were retrieved from local medical databases. Mean calculated 3-year overall survival (OS) reached 70% (mean follow-up 35.3 months). The association between lower LMR and the presence of tumor necrosis (p = 0.0004) was observed. Amongst systemic inflammatory markers, only LMR was selected as the sensitive marker predicting death with a calculated cut-off value of 2.53. OS was decreased in patients presenting with low LMR when compared to the high LMR group (39% vs. 82%, p = 0.0011). Neither NLR nor PLR were associated with survival rates. In multivariate analysis, LMR was identified as the independent prognostic factor (HR = 0.20, 95% CI 0.07–0.55, p = 0.001). Low values of LMR (<2.53) are independently connected with poorer OS in patients with RCC and coexisting tumor thrombus. The incorporation of the hematological variables into the prognostic model greatly increased its accuracy in predicting survival in the distinctive subpopulation of patients with RCC.
format Online
Article
Text
id pubmed-8623560
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86235602021-11-27 Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus Zapała, Łukasz Kunc, Michał Sharma, Sumit Biernat, Wojciech Radziszewski, Piotr Diagnostics (Basel) Article The purpose of the study was to determine the influence of lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) values on the prognosis in patients with renal cell carcinoma (RCC) and venous tumor thrombus. The respective data of 91 patients treated with radical surgery in the years 2012–2021 in 2 tertiary referral urological centers were retrieved from local medical databases. Mean calculated 3-year overall survival (OS) reached 70% (mean follow-up 35.3 months). The association between lower LMR and the presence of tumor necrosis (p = 0.0004) was observed. Amongst systemic inflammatory markers, only LMR was selected as the sensitive marker predicting death with a calculated cut-off value of 2.53. OS was decreased in patients presenting with low LMR when compared to the high LMR group (39% vs. 82%, p = 0.0011). Neither NLR nor PLR were associated with survival rates. In multivariate analysis, LMR was identified as the independent prognostic factor (HR = 0.20, 95% CI 0.07–0.55, p = 0.001). Low values of LMR (<2.53) are independently connected with poorer OS in patients with RCC and coexisting tumor thrombus. The incorporation of the hematological variables into the prognostic model greatly increased its accuracy in predicting survival in the distinctive subpopulation of patients with RCC. MDPI 2021-11-21 /pmc/articles/PMC8623560/ /pubmed/34829506 http://dx.doi.org/10.3390/diagnostics11112159 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zapała, Łukasz
Kunc, Michał
Sharma, Sumit
Biernat, Wojciech
Radziszewski, Piotr
Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus
title Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus
title_full Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus
title_fullStr Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus
title_full_unstemmed Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus
title_short Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus
title_sort low lymphocyte-to-monocyte ratio is the potential indicator of worse overall survival in patients with renal cell carcinoma and venous tumor thrombus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623560/
https://www.ncbi.nlm.nih.gov/pubmed/34829506
http://dx.doi.org/10.3390/diagnostics11112159
work_keys_str_mv AT zapałałukasz lowlymphocytetomonocyteratioisthepotentialindicatorofworseoverallsurvivalinpatientswithrenalcellcarcinomaandvenoustumorthrombus
AT kuncmichał lowlymphocytetomonocyteratioisthepotentialindicatorofworseoverallsurvivalinpatientswithrenalcellcarcinomaandvenoustumorthrombus
AT sharmasumit lowlymphocytetomonocyteratioisthepotentialindicatorofworseoverallsurvivalinpatientswithrenalcellcarcinomaandvenoustumorthrombus
AT biernatwojciech lowlymphocytetomonocyteratioisthepotentialindicatorofworseoverallsurvivalinpatientswithrenalcellcarcinomaandvenoustumorthrombus
AT radziszewskipiotr lowlymphocytetomonocyteratioisthepotentialindicatorofworseoverallsurvivalinpatientswithrenalcellcarcinomaandvenoustumorthrombus