Cargando…

Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus

Components of the translation apparatus, including ribosomal proteins, have been found in cell nuclei in various organisms. Components of the translation apparatus are involved in various nuclear processes, particularly those associated with genome integrity control and the nuclear stages of gene ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Kachaev, Zaur M., Ivashchenko, Sergey D., Kozlov, Eugene N., Lebedeva, Lyubov A., Shidlovskii, Yulii V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623629/
https://www.ncbi.nlm.nih.gov/pubmed/34831461
http://dx.doi.org/10.3390/cells10113239
_version_ 1784605978418741248
author Kachaev, Zaur M.
Ivashchenko, Sergey D.
Kozlov, Eugene N.
Lebedeva, Lyubov A.
Shidlovskii, Yulii V.
author_facet Kachaev, Zaur M.
Ivashchenko, Sergey D.
Kozlov, Eugene N.
Lebedeva, Lyubov A.
Shidlovskii, Yulii V.
author_sort Kachaev, Zaur M.
collection PubMed
description Components of the translation apparatus, including ribosomal proteins, have been found in cell nuclei in various organisms. Components of the translation apparatus are involved in various nuclear processes, particularly those associated with genome integrity control and the nuclear stages of gene expression, such as transcription, mRNA processing, and mRNA export. Components of the translation apparatus control intranuclear trafficking; the nuclear import and export of RNA and proteins; and regulate the activity, stability, and functional recruitment of nuclear proteins. The nuclear translocation of these components is often involved in the cell response to stimulation and stress, in addition to playing critical roles in oncogenesis and viral infection. Many components of the translation apparatus are moonlighting proteins, involved in integral cell stress response and coupling of gene expression subprocesses. Thus, this phenomenon represents a significant interest for both basic and applied molecular biology. Here, we provide an overview of the current data regarding the molecular functions of translation factors and ribosomal proteins in the cell nucleus.
format Online
Article
Text
id pubmed-8623629
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86236292021-11-27 Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus Kachaev, Zaur M. Ivashchenko, Sergey D. Kozlov, Eugene N. Lebedeva, Lyubov A. Shidlovskii, Yulii V. Cells Review Components of the translation apparatus, including ribosomal proteins, have been found in cell nuclei in various organisms. Components of the translation apparatus are involved in various nuclear processes, particularly those associated with genome integrity control and the nuclear stages of gene expression, such as transcription, mRNA processing, and mRNA export. Components of the translation apparatus control intranuclear trafficking; the nuclear import and export of RNA and proteins; and regulate the activity, stability, and functional recruitment of nuclear proteins. The nuclear translocation of these components is often involved in the cell response to stimulation and stress, in addition to playing critical roles in oncogenesis and viral infection. Many components of the translation apparatus are moonlighting proteins, involved in integral cell stress response and coupling of gene expression subprocesses. Thus, this phenomenon represents a significant interest for both basic and applied molecular biology. Here, we provide an overview of the current data regarding the molecular functions of translation factors and ribosomal proteins in the cell nucleus. MDPI 2021-11-19 /pmc/articles/PMC8623629/ /pubmed/34831461 http://dx.doi.org/10.3390/cells10113239 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kachaev, Zaur M.
Ivashchenko, Sergey D.
Kozlov, Eugene N.
Lebedeva, Lyubov A.
Shidlovskii, Yulii V.
Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus
title Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus
title_full Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus
title_fullStr Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus
title_full_unstemmed Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus
title_short Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus
title_sort localization and functional roles of components of the translation apparatus in the eukaryotic cell nucleus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623629/
https://www.ncbi.nlm.nih.gov/pubmed/34831461
http://dx.doi.org/10.3390/cells10113239
work_keys_str_mv AT kachaevzaurm localizationandfunctionalrolesofcomponentsofthetranslationapparatusintheeukaryoticcellnucleus
AT ivashchenkosergeyd localizationandfunctionalrolesofcomponentsofthetranslationapparatusintheeukaryoticcellnucleus
AT kozloveugenen localizationandfunctionalrolesofcomponentsofthetranslationapparatusintheeukaryoticcellnucleus
AT lebedevalyubova localizationandfunctionalrolesofcomponentsofthetranslationapparatusintheeukaryoticcellnucleus
AT shidlovskiiyuliiv localizationandfunctionalrolesofcomponentsofthetranslationapparatusintheeukaryoticcellnucleus