Molecular Mechanisms of Cereblon-Interacting Small Molecules in Multiple Myeloma Therapy

Thalidomide analogues (or immunomodulatory imide drugs, IMiDs) are cornerstones in the treatment of multiple myeloma (MM). These drugs bind Cereblon (CRBN), a receptor for the Cullin-ring 4 ubiquitin-ligase (CRL4) complex, to modify its substrate specificity. IMiDs mediate CRBN-dependent engagement...

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Detalles Bibliográficos
Autores principales: Costacurta, Matteo, He, Jackson, Thompson, Philip E., Shortt, Jake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623651/
https://www.ncbi.nlm.nih.gov/pubmed/34834536
http://dx.doi.org/10.3390/jpm11111185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623651/
https://www.ncbi.nlm.nih.gov/pubmed/34834536
http://dx.doi.org/10.3390/jpm11111185

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