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Immunohistochemistry for Thymidine Kinase-1 (TK1): A Potential Tool for the Prognostic Stratification of Breast Cancer Patients

Breast cancer (BC) is the most frequent non-cutaneous malignancy in women. Histological grade, expression of estrogen and progesterone receptors (ER and PgR), overexpression/amplification of the human epidermal growth factor receptor 2 (HER2) oncogene, and proliferative activity measured with ki-67...

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Autores principales: Fanelli, Giuseppe Nicolò, Scarpitta, Rosa, Cinacchi, Paola, Fuochi, Beatrice, Szumera-Ciećkiewicz, Anna, De Ieso, Katia, Ferrari, Paola, Fontana, Andrea, Miccoli, Mario, Naccarato, Antonio Giuseppe, Scatena, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623797/
https://www.ncbi.nlm.nih.gov/pubmed/34830698
http://dx.doi.org/10.3390/jcm10225416
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author Fanelli, Giuseppe Nicolò
Scarpitta, Rosa
Cinacchi, Paola
Fuochi, Beatrice
Szumera-Ciećkiewicz, Anna
De Ieso, Katia
Ferrari, Paola
Fontana, Andrea
Miccoli, Mario
Naccarato, Antonio Giuseppe
Scatena, Cristian
author_facet Fanelli, Giuseppe Nicolò
Scarpitta, Rosa
Cinacchi, Paola
Fuochi, Beatrice
Szumera-Ciećkiewicz, Anna
De Ieso, Katia
Ferrari, Paola
Fontana, Andrea
Miccoli, Mario
Naccarato, Antonio Giuseppe
Scatena, Cristian
author_sort Fanelli, Giuseppe Nicolò
collection PubMed
description Breast cancer (BC) is the most frequent non-cutaneous malignancy in women. Histological grade, expression of estrogen and progesterone receptors (ER and PgR), overexpression/amplification of the human epidermal growth factor receptor 2 (HER2) oncogene, and proliferative activity measured with ki-67 provide important information on the biological features of BC and guide treatment choices. However, a biomarker that allows a more accurate prognostic stratification is still lacking. Thymidine kinase-1 (TK1), a ubiquitous enzyme involved in the pyrimidine nucleotide recovery pathway, is a cell-proliferation marker with potential prognostic and predictive impacts in BC. Eighty (80) cases of invasive BC with a long-term follow-up were retrospectively selected, and clinicopathological data were collected for each patient. TK1 tissue expression was evaluated immunohistochemically. Data suggested that TK1 expression levels are positively correlated with ER and PgR expression, and negatively correlated with HER2 status and the impact on patients’ distant recurrence-free survival (DRFS): in detail, among patients undergoing adjuvant chemotherapy, lower TK1 levels are correlated with better DRFS. Therefore, these results contribute to furthering the knowledge of TK1, suggesting a possible and important role of this enzyme as a biomarker in the stratification of BC patients.
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spelling pubmed-86237972021-11-27 Immunohistochemistry for Thymidine Kinase-1 (TK1): A Potential Tool for the Prognostic Stratification of Breast Cancer Patients Fanelli, Giuseppe Nicolò Scarpitta, Rosa Cinacchi, Paola Fuochi, Beatrice Szumera-Ciećkiewicz, Anna De Ieso, Katia Ferrari, Paola Fontana, Andrea Miccoli, Mario Naccarato, Antonio Giuseppe Scatena, Cristian J Clin Med Article Breast cancer (BC) is the most frequent non-cutaneous malignancy in women. Histological grade, expression of estrogen and progesterone receptors (ER and PgR), overexpression/amplification of the human epidermal growth factor receptor 2 (HER2) oncogene, and proliferative activity measured with ki-67 provide important information on the biological features of BC and guide treatment choices. However, a biomarker that allows a more accurate prognostic stratification is still lacking. Thymidine kinase-1 (TK1), a ubiquitous enzyme involved in the pyrimidine nucleotide recovery pathway, is a cell-proliferation marker with potential prognostic and predictive impacts in BC. Eighty (80) cases of invasive BC with a long-term follow-up were retrospectively selected, and clinicopathological data were collected for each patient. TK1 tissue expression was evaluated immunohistochemically. Data suggested that TK1 expression levels are positively correlated with ER and PgR expression, and negatively correlated with HER2 status and the impact on patients’ distant recurrence-free survival (DRFS): in detail, among patients undergoing adjuvant chemotherapy, lower TK1 levels are correlated with better DRFS. Therefore, these results contribute to furthering the knowledge of TK1, suggesting a possible and important role of this enzyme as a biomarker in the stratification of BC patients. MDPI 2021-11-19 /pmc/articles/PMC8623797/ /pubmed/34830698 http://dx.doi.org/10.3390/jcm10225416 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fanelli, Giuseppe Nicolò
Scarpitta, Rosa
Cinacchi, Paola
Fuochi, Beatrice
Szumera-Ciećkiewicz, Anna
De Ieso, Katia
Ferrari, Paola
Fontana, Andrea
Miccoli, Mario
Naccarato, Antonio Giuseppe
Scatena, Cristian
Immunohistochemistry for Thymidine Kinase-1 (TK1): A Potential Tool for the Prognostic Stratification of Breast Cancer Patients
title Immunohistochemistry for Thymidine Kinase-1 (TK1): A Potential Tool for the Prognostic Stratification of Breast Cancer Patients
title_full Immunohistochemistry for Thymidine Kinase-1 (TK1): A Potential Tool for the Prognostic Stratification of Breast Cancer Patients
title_fullStr Immunohistochemistry for Thymidine Kinase-1 (TK1): A Potential Tool for the Prognostic Stratification of Breast Cancer Patients
title_full_unstemmed Immunohistochemistry for Thymidine Kinase-1 (TK1): A Potential Tool for the Prognostic Stratification of Breast Cancer Patients
title_short Immunohistochemistry for Thymidine Kinase-1 (TK1): A Potential Tool for the Prognostic Stratification of Breast Cancer Patients
title_sort immunohistochemistry for thymidine kinase-1 (tk1): a potential tool for the prognostic stratification of breast cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623797/
https://www.ncbi.nlm.nih.gov/pubmed/34830698
http://dx.doi.org/10.3390/jcm10225416
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