Cargando…

The Structural Determinants for α(1)-Adrenergic/Serotonin Receptors Activity among Phenylpiperazine-Hydantoin Derivatives

Several studies confirmed the reciprocal interactions between adrenergic and serotoninergic systems and the influence of these phenomena on the pathogenesis of anxiety. Hence, searching for chemical agents with a multifunctional pharmacodynamic profile may bring highly effective therapy for CNS diso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kucwaj-Brysz, Katarzyna, Dela, Anna, Podlewska, Sabina, Bednarski, Marek, Siwek, Agata, Satała, Grzegorz, Czarnota, Kinga, Handzlik, Jadwiga, Kieć-Kononowicz, Katarzyna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623851/ https://www.ncbi.nlm.nih.gov/pubmed/34834117 http://dx.doi.org/10.3390/molecules26227025

Ejemplares similares

Multitargeting the Action of 5-HT(6) Serotonin Receptor Ligands by Additional Modulation of Kinases in the Search for a New Therapy for Alzheimer’s Disease: Can It Work from a Molecular Point of View?
por: Czarnota-Łydka, Kinga, et al.
Publicado: (2022)

Phenylpiperazine 5,5-Dimethylhydantoin Derivatives as First Synthetic Inhibitors of Msr(A) Efflux Pump in Staphylococcus epidermidis
por: Witek, Karolina, et al.
Publicado: (2020)

Efflux Pump Blockers in Gram-Negative Bacteria: The New Generation of Hydantoin Based-Modulators to Improve Antibiotic Activity
por: Otręebska-Machaj, Ewa, et al.
Publicado: (2016)

The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT(6) Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment
por: Latacz, Gniewomir, et al.
Publicado: (2019)

Recent Advances in Multi-Drug Resistance (MDR) Efflux Pump Inhibitors of Gram-Positive Bacteria S. aureus
por: Handzlik, Jadwiga, et al.
Publicado: (2013)

Evaluation of Some Safety Parameters of Dual Histamine H(3) and Sigma-2 Receptor Ligands with Anti-Obesity Potential
por: Mika, Kamil, et al.
Publicado: (2023)

Are the Hydantoin-1,3,5-triazine 5-HT(6)R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro
por: Lubelska, Annamaria, et al.
Publicado: (2019)

Structure Prediction, Evaluation, and Validation of GPR18 Lipid Receptor Using Free Programs
por: Michalik, Ilona, et al.
Publicado: (2022)

The Phenoxyalkyltriazine Antagonists for 5-HT(6) Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases
por: Sudoł, Sylwia, et al.
Publicado: (2021)

Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT(6) Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo
por: Kurczab, Rafał, et al.
Publicado: (2018)

Low Basicity as a Characteristic for Atypical Ligands of Serotonin Receptor 5-HT2
por: Podlewska, Sabina, et al.
Publicado: (2021)

Studies on Anticonvulsant Effects of Novel Histamine H3R Antagonists in Electrically and Chemically Induced Seizures in Rats
por: Alachkar, Alaa, et al.
Publicado: (2018)

The Significance of Halogen Bonding in Ligand–Receptor Interactions: The Lesson Learned from Molecular Dynamic Simulations of the D(4) Receptor
por: Kurczab, Rafał, et al.
Publicado: (2019)

5-Arylideneimidazolones with Amine at Position 3 as Potential Antibiotic Adjuvants against Multidrug Resistant Bacteria
por: Kaczor, Aneta, et al.
Publicado: (2019)

Low-basicity 5-HT(7) Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol
por: Hogendorf, Adam S., et al.
Publicado: (2017)

Xanthine–Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases
por: Załuski, Michał, et al.
Publicado: (2023)

Histamine H(3) Receptor Ligands—KSK-59 and KSK-73—Reduce Body Weight Gain in a Rat Model of Excessive Eating
por: Mika, Kamil, et al.
Publicado: (2021)

Novel serotonin 5-HT(2A) receptor antagonists derived from 4-phenylcyclohexane-5-spiro-and 5-methyl-5-phenyl-hydantoin, for use as potential antiplatelet agents
por: Czopek, Anna, et al.
Publicado: (2021)

New Triazine Derivatives as Serotonin 5-HT(6) Receptor Ligands
por: Łażewska, Dorota, et al.
Publicado: (2023)

Anti-inflammatory effects of new human histamine H(3) receptor ligands with flavonoid structure on BV-2 neuroinflammation
por: Honkisz-Orzechowska, Ewelina, et al.
Publicado: (2022)

Chalcogen-Varied Imidazolone Derivatives as Antibiotic Resistance Breakers in Staphylococcus aureus Strains
por: Witek, Karolina, et al.
Publicado: (2023)

Antidepressants Differentially Regulate Intracellular Signaling from α1-Adrenergic Receptor Subtypes In Vitro
por: Chmielarz, Piotr, et al.
Publicado: (2021)

Synthesis, biological activity and molecular modelling studies of tricyclic alkylimidazo-, pyrimido- and diazepinopurinediones
por: Drabczyńska, Anna, et al.
Publicado: (2013)

Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H(3) and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties
por: Szczepańska, Katarzyna, et al.
Publicado: (2021)

Study on the effect of EMD386088, a 5-HT(6) receptor partial agonist, in enhancing the anti-immobility action of some antidepressants in rats
por: Jastrzębska-Więsek, Magdalena, et al.
Publicado: (2017)

Aspects of a Distinct Cytotoxicity of Selenium Salts and Organic Selenides in Living Cells with Possible Implications for Drug Design
por: Castellucci Estevam, Ethiene, et al.
Publicado: (2015)

The Stereoselectivity and Hydrolysis Efficiency of Recombinant d-Hydantoinase from Vigna angularis Against 5-Benzylhydantoin Derivatives with Halogen and Methyl Substituents
por: Latacz, Gniewomir, et al.
Publicado: (2014)

Evaluation of phenylpiperazines as targeting agents for neuroblastoma.
por: Babich, J. W., et al.
Publicado: (1996)

Synthesis and acaricidal activity of phenylpiperazine derivatives
por: Suzuki, Jun, et al.
Publicado: (2021)

Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors
por: Mosolygó, Tímea, et al.
Publicado: (2019)

Selenazolinium Salts as “Small Molecule Catalysts” with High Potency against ESKAPE Bacterial Pathogens
por: Witek, Karolina, et al.
Publicado: (2017)

Synthesis and Activity of Novel Acylthiourea with Hydantoin
por: Han, Jintao, et al.
Publicado: (2013)

Phase-Transfer-Catalyzed Alkylation of Hydantoins
por: Keenan, Thomas, et al.
Publicado: (2022)

Chalcones as Potential Ligands for the Treatment of Parkinson’s Disease
por: Królicka, Ewelina, et al.
Publicado: (2022)

The GPR18 Agonist PSB-KD-107 Exerts Endothelium-Dependent Vasorelaxant Effects
por: Kotańska, Magdalena, et al.
Publicado: (2021)

N-Skatyltryptamines—Dual 5-HT(6)R/D(2)R Ligands with Antipsychotic and Procognitive Potential
por: Hogendorf, Agata, et al.
Publicado: (2021)

4-Phenylpiperazin-1-ium dihydrogen phosphate
por: Essid, Manel, et al.
Publicado: (2010)

Study on the Formation of Glycine by Hydantoin and Its Kinetics
por: Zhao, Hangyu, et al.
Publicado: (2020)

Biologically Oriented Hybrids of Indole and Hydantoin Derivatives
por: Kochetkov, Konstantin A., et al.
Publicado: (2023)

Preliminary Evidence of the Potent and Selective Adenosine A2B Receptor Antagonist PSB-603 in Reducing Obesity and Some of Its Associated Metabolic Disorders in Mice
por: Kotańska, Magdalena, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_b573fmdn9n7iphatsroepdok4g