A Rare Case of Waldenstrom Macroglobulinemia of the Rectosigmoid Colon

Waldenstrom macroglobulinemia is an uncommon mature B-cell lymphoma characterized by monoclonal immunoglobulin M protein in peripheral blood and lymphoplasmacytic cells in bone marrow and/or extramedullary sites. The gastrointestinal tract is a rare site of involvement. The diagnosis is based on cli...

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Autores principales: Zelman, Sara, Russell, Michael B., Hojat, Amin, Pilichowska, Monika, Olans, Lori B., Sterling, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624017/
https://www.ncbi.nlm.nih.gov/pubmed/34849377
http://dx.doi.org/10.14309/crj.0000000000000689
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author Zelman, Sara
Russell, Michael B.
Hojat, Amin
Pilichowska, Monika
Olans, Lori B.
Sterling, Mark J.
author_facet Zelman, Sara
Russell, Michael B.
Hojat, Amin
Pilichowska, Monika
Olans, Lori B.
Sterling, Mark J.
author_sort Zelman, Sara
collection PubMed
description Waldenstrom macroglobulinemia is an uncommon mature B-cell lymphoma characterized by monoclonal immunoglobulin M protein in peripheral blood and lymphoplasmacytic cells in bone marrow and/or extramedullary sites. The gastrointestinal tract is a rare site of involvement. The diagnosis is based on clinicopathologic findings, although somatic mutations, such as MYD88, can aid in the diagnosis. We present a patient with irregular stools diagnosed with Waldenstrom macroglobulinemia involving the rectosigmoid colon by histopathology and immunohistochemistry on colonic biopsies, immunoglobulin M protein in serum, clonal plasma cells in bone marrow, and MYD88 mutation in colonic and bone marrow specimens.
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spelling pubmed-86240172021-11-29 A Rare Case of Waldenstrom Macroglobulinemia of the Rectosigmoid Colon Zelman, Sara Russell, Michael B. Hojat, Amin Pilichowska, Monika Olans, Lori B. Sterling, Mark J. ACG Case Rep J Case Report Waldenstrom macroglobulinemia is an uncommon mature B-cell lymphoma characterized by monoclonal immunoglobulin M protein in peripheral blood and lymphoplasmacytic cells in bone marrow and/or extramedullary sites. The gastrointestinal tract is a rare site of involvement. The diagnosis is based on clinicopathologic findings, although somatic mutations, such as MYD88, can aid in the diagnosis. We present a patient with irregular stools diagnosed with Waldenstrom macroglobulinemia involving the rectosigmoid colon by histopathology and immunohistochemistry on colonic biopsies, immunoglobulin M protein in serum, clonal plasma cells in bone marrow, and MYD88 mutation in colonic and bone marrow specimens. Wolters Kluwer 2021-11-29 /pmc/articles/PMC8624017/ /pubmed/34849377 http://dx.doi.org/10.14309/crj.0000000000000689 Text en © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Zelman, Sara
Russell, Michael B.
Hojat, Amin
Pilichowska, Monika
Olans, Lori B.
Sterling, Mark J.
A Rare Case of Waldenstrom Macroglobulinemia of the Rectosigmoid Colon
title A Rare Case of Waldenstrom Macroglobulinemia of the Rectosigmoid Colon
title_full A Rare Case of Waldenstrom Macroglobulinemia of the Rectosigmoid Colon
title_fullStr A Rare Case of Waldenstrom Macroglobulinemia of the Rectosigmoid Colon
title_full_unstemmed A Rare Case of Waldenstrom Macroglobulinemia of the Rectosigmoid Colon
title_short A Rare Case of Waldenstrom Macroglobulinemia of the Rectosigmoid Colon
title_sort rare case of waldenstrom macroglobulinemia of the rectosigmoid colon
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624017/
https://www.ncbi.nlm.nih.gov/pubmed/34849377
http://dx.doi.org/10.14309/crj.0000000000000689
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