Cargando…

Insulin-like Growth Factor Binding Protein-2 (IGFBP2) Is a Key Molecule in the MACC1-Mediated Platelet Communication and Metastasis of Colorectal Cancer Cells

Tumor cell crosstalk with platelets and, subsequently, their activation are key steps in hematogenous tumor metastasis. MACC1 is an oncogene involved in molecular pathogenesis of colorectal cancer (CRC) and other solid tumor entities, mediating motility and metastasis, making MACC1 an accepted progn...

Descripción completa

Detalles Bibliográficos
Autores principales:	Haschemi, Reza, Kobelt, Dennis, Steinwarz, Elisabeth, Schlesinger, Martin, Stein, Ulrike, Bendas, Gerd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624049/ https://www.ncbi.nlm.nih.gov/pubmed/34830078 http://dx.doi.org/10.3390/ijms222212195

Ejemplares similares

A Combined Activity of Thrombin and P-Selectin Is Essential for Platelet Activation by Pancreatic Cancer Cells
por: Haschemi, Reza, et al.
Publicado: (2021)

MACC1-Induced Collective Migration Is Promoted by Proliferation Rather Than Single Cell Biomechanics
por: Hohmann, Tim, et al.
Publicado: (2022)

MACC1 driven alterations in cellular biomechanics facilitate cell motility in glioblastoma
por: Hohmann, Tim, et al.
Publicado: (2020)

Restoring Treatment Response in Colorectal Cancer Cells by Targeting MACC1-Dependent ABCB1 Expression in Combination Therapy
por: Dahlmann, Mathias, et al.
Publicado: (2020)

The mechanisms how heparin affects the tumor cell induced VEGF and chemokine release from platelets to attenuate the early metastatic niche formation
por: Ponert, Jan Moritz, et al.
Publicado: (2018)

Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association
por: Bähr, Ina, et al.
Publicado: (2022)

Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1
por: Juneja, Manisha, et al.
Publicado: (2017)

Inhibition of MACC1-Induced Metastasis in Esophageal and Gastric Adenocarcinomas
por: Treese, Christoph, et al.
Publicado: (2022)

Systematic Identification of MACC1-Driven Metabolic Networks in Colorectal Cancer
por: Lisec, Jan, et al.
Publicado: (2021)

Pro-inflammatory TNF-α and IFN-γ Promote Tumor Growth and Metastasis via Induction of MACC1
por: Kobelt, Dennis, et al.
Publicado: (2020)

The GPIb-IX complex on platelets: insight into its novel physiological functions affecting immune surveillance, hepatic thrombopoietin generation, platelet clearance and its relevance for cancer development and metastasis
por: Bendas, Gerd, et al.
Publicado: (2022)

Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer
por: Link, Theresa, et al.
Publicado: (2019)

Circulating MACC1 Transcripts in Glioblastoma Patients Predict Prognosis and Treatment Response
por: Hagemann, Carsten, et al.
Publicado: (2019)

Saffron Crudes and Compounds Restrict MACC1-Dependent Cell Proliferation and Migration of Colorectal Cancer Cells
por: Güllü, Nazli, et al.
Publicado: (2020)

Calcium-binding protein S100P is a new target gene of MACC1, drives colorectal cancer metastasis and serves as a prognostic biomarker
por: Schmid, Felicitas, et al.
Publicado: (2022)

Elevated MACC1 Expression in Colorectal Cancer Is Driven by Chromosomal Instability and Is Associated with Molecular Subtype and Worse Patient Survival
por: Vuaroqueaux, Vincent, et al.
Publicado: (2022)

Combinatorial treatment with statins and niclosamide prevents CRC dissemination by unhinging the MACC1-β-catenin-S100A4 axis of metastasis
por: Kortüm, Benedikt, et al.
Publicado: (2022)

The newly identified MEK1 tyrosine phosphorylation target MACC1 is druggable by approved MEK1 inhibitors to restrict colorectal cancer metastasis
por: Kobelt, Dennis, et al.
Publicado: (2021)

MACC1-Dependent Antitumor Effect of Curcumin in Colorectal Cancer
por: Güllü, Nazli, et al.
Publicado: (2022)

Tumour cell-activated platelets modulate the immunological activity of CD4(+), CD8(+), and NK cells, which is efficiently antagonized by heparin
por: Gockel, Lukas M., et al.
Publicado: (2022)

The Low Molecular Weight Heparin Tinzaparin Attenuates Platelet Activation in Terms of Metastatic Niche Formation by Coagulation-Dependent and Independent Pathways
por: Gockel, Lukas Maria, et al.
Publicado: (2018)

MACC1 is post-transcriptionally regulated by miR-218 in colorectal cancer
por: Ilm, Katharina, et al.
Publicado: (2016)

Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders
por: Steinebach, Christian, et al.
Publicado: (2020)

Targeting Discoidin Domain Receptor 1 (DDR1) Signaling and Its Crosstalk with β(1)-Integrin Emerges as a Key Factor for Breast Cancer Chemosensitization upon Collagen Type 1 Binding
por: Baltes, Fabian, et al.
Publicado: (2020)

Glycosaminoglycans as Tools to Decipher the Platelet Tumor Cell Interaction: A Focus on P-Selectin
por: Schwarz, Svenja, et al.
Publicado: (2020)

SNPs in the coding region of the metastasis-inducing gene MACC1 and clinical outcome in colorectal cancer
por: Schmid, Felicitas, et al.
Publicado: (2012)

Circulating MACC1 Transcripts in Colorectal Cancer Patient Plasma Predict Metastasis and Prognosis
por: Stein, Ulrike, et al.
Publicado: (2012)

Quantification of mRNA Expression Using Single-Molecule Nanopore Sensing
por: Rozevsky, Yana, et al.
Publicado: (2020)

Increased MACC1 levels in tissues and blood identify colon adenoma patients at high risk
por: Ashktorab, Hassan, et al.
Publicado: (2016)

Increased Concentrations of Insulin-Like Growth Factor Binding Protein (IGFBP)-2, IGFBP-3, and IGFBP-4 Are Associated With Fetal Mortality in Pregnant Cows
por: Mense, Kirsten, et al.
Publicado: (2018)

Small Ones to Fight a Big Problem—Intervention of Cancer Metastasis by Small Molecules
por: Kobelt, Dennis, et al.
Publicado: (2020)

Multicomponent reactions provide key molecules for secret communication
por: Boukis, Andreas C., et al.
Publicado: (2018)

Core-Clock Genes Regulate Proliferation and Invasion via a Reciprocal Interplay with MACC1 in Colorectal Cancer Cells
por: Basti, Alireza, et al.
Publicado: (2022)

Cantharidin and Its Analogue Norcantharidin Inhibit Metastasis—Inducing Genes S100A4 and MACC1
por: Schöpe, Paul Curtis, et al.
Publicado: (2023)

Mechanisms of Matrix-Induced Chemoresistance of Breast Cancer Cells—Deciphering Novel Potential Targets for a Cell Sensitization
por: Jakubzig, Bastian, et al.
Publicado: (2018)

Insulin Growth Factor Binding Protein 7 (IGFBP7)-Related Cancer and IGFBP3 and IGFBP7 Crosstalk
por: Jin, Li, et al.
Publicado: (2020)

Raised serum levels of IGFBP-1 and IGFBP-2 in idiopathic pulmonary fibrosis
por: Guiot, J., et al.
Publicado: (2016)

LncRNA MACC1-AS1 associates with DDX5 to modulate MACC1 transcription in breast cancer cells
por: Zheng, Guiyu, et al.
Publicado: (2023)

High MACC1 expression in combination with mutated KRAS G13 indicates poor survival of colorectal cancer patients
por: Ilm, Katharina, et al.
Publicado: (2015)

MACC1 regulates clathrin-mediated endocytosis and receptor recycling of transferrin receptor and EGFR in colorectal cancer
por: Imbastari, Francesca, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5dbss3uoeuqe5pae1cnc6ulkgr