Cargando…
Neutrophils in Streptococcus suis Infection: From Host Defense to Pathology
Streptococcus suis is a swine pathogen and zoonotic agent responsible for economic losses to the porcine industry. Infected animals may develop meningitis, arthritis, endocarditis, sepsis and/or sudden death. The pathogenesis of the infection implies that bacteria breach mucosal host barriers and re...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624082/ https://www.ncbi.nlm.nih.gov/pubmed/34835517 http://dx.doi.org/10.3390/microorganisms9112392 |
_version_ | 1784606086575161344 |
---|---|
author | Bleuzé, Marêva Gottschalk, Marcelo Segura, Mariela |
author_facet | Bleuzé, Marêva Gottschalk, Marcelo Segura, Mariela |
author_sort | Bleuzé, Marêva |
collection | PubMed |
description | Streptococcus suis is a swine pathogen and zoonotic agent responsible for economic losses to the porcine industry. Infected animals may develop meningitis, arthritis, endocarditis, sepsis and/or sudden death. The pathogenesis of the infection implies that bacteria breach mucosal host barriers and reach the bloodstream, where they escape immune-surveillance mechanisms and spread throughout the organism. The clinical manifestations are mainly the consequence of an exacerbated inflammation, defined by an exaggerated production of cytokines and recruitment of immune cells. Among them, neutrophils arrive first in contact with the pathogens to combat the infection. Neutrophils initiate and maintain inflammation, by producing cytokines and deploying their arsenal of antimicrobial mechanisms. Furthermore, neutrophilic leukocytosis characterizes S. suis infection, and lesions of infected subjects contain a large number of neutrophils. Therefore, this cell type may play a role in host defense and/or in the exacerbated inflammation. Nevertheless, a limited number of studies addressed the role or functions of neutrophils in the context of S. suis infection. In this review, we will explore the literature about S. suis and neutrophils, from their interaction at a cellular level, to the roles and behaviors of neutrophils in the infected host in vivo. |
format | Online Article Text |
id | pubmed-8624082 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86240822021-11-27 Neutrophils in Streptococcus suis Infection: From Host Defense to Pathology Bleuzé, Marêva Gottschalk, Marcelo Segura, Mariela Microorganisms Review Streptococcus suis is a swine pathogen and zoonotic agent responsible for economic losses to the porcine industry. Infected animals may develop meningitis, arthritis, endocarditis, sepsis and/or sudden death. The pathogenesis of the infection implies that bacteria breach mucosal host barriers and reach the bloodstream, where they escape immune-surveillance mechanisms and spread throughout the organism. The clinical manifestations are mainly the consequence of an exacerbated inflammation, defined by an exaggerated production of cytokines and recruitment of immune cells. Among them, neutrophils arrive first in contact with the pathogens to combat the infection. Neutrophils initiate and maintain inflammation, by producing cytokines and deploying their arsenal of antimicrobial mechanisms. Furthermore, neutrophilic leukocytosis characterizes S. suis infection, and lesions of infected subjects contain a large number of neutrophils. Therefore, this cell type may play a role in host defense and/or in the exacerbated inflammation. Nevertheless, a limited number of studies addressed the role or functions of neutrophils in the context of S. suis infection. In this review, we will explore the literature about S. suis and neutrophils, from their interaction at a cellular level, to the roles and behaviors of neutrophils in the infected host in vivo. MDPI 2021-11-20 /pmc/articles/PMC8624082/ /pubmed/34835517 http://dx.doi.org/10.3390/microorganisms9112392 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bleuzé, Marêva Gottschalk, Marcelo Segura, Mariela Neutrophils in Streptococcus suis Infection: From Host Defense to Pathology |
title | Neutrophils in Streptococcus suis Infection: From Host Defense to Pathology |
title_full | Neutrophils in Streptococcus suis Infection: From Host Defense to Pathology |
title_fullStr | Neutrophils in Streptococcus suis Infection: From Host Defense to Pathology |
title_full_unstemmed | Neutrophils in Streptococcus suis Infection: From Host Defense to Pathology |
title_short | Neutrophils in Streptococcus suis Infection: From Host Defense to Pathology |
title_sort | neutrophils in streptococcus suis infection: from host defense to pathology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624082/ https://www.ncbi.nlm.nih.gov/pubmed/34835517 http://dx.doi.org/10.3390/microorganisms9112392 |
work_keys_str_mv | AT bleuzemareva neutrophilsinstreptococcussuisinfectionfromhostdefensetopathology AT gottschalkmarcelo neutrophilsinstreptococcussuisinfectionfromhostdefensetopathology AT seguramariela neutrophilsinstreptococcussuisinfectionfromhostdefensetopathology |