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Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up

We report an unprecedented case of a young patient with epilepsy coexisting with acute zonal occult outer retinopathy (AZOOR), a rare white dot syndrome of unknown etiology, associated with damage to the large zones of the outer retina. Recently, it has been established that epileptic episodes contr...

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Autores principales: Karska-Basta, Izabella, Romanowska-Dixon, Bożena, Pojda-Wilczek, Dorota, Bakunowicz-Łazarczyk, Alina, Kubicka-Trząska, Agnieszka, Gerba-Górecka, Karolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624097/
https://www.ncbi.nlm.nih.gov/pubmed/34833494
http://dx.doi.org/10.3390/medicina57111276
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author Karska-Basta, Izabella
Romanowska-Dixon, Bożena
Pojda-Wilczek, Dorota
Bakunowicz-Łazarczyk, Alina
Kubicka-Trząska, Agnieszka
Gerba-Górecka, Karolina
author_facet Karska-Basta, Izabella
Romanowska-Dixon, Bożena
Pojda-Wilczek, Dorota
Bakunowicz-Łazarczyk, Alina
Kubicka-Trząska, Agnieszka
Gerba-Górecka, Karolina
author_sort Karska-Basta, Izabella
collection PubMed
description We report an unprecedented case of a young patient with epilepsy coexisting with acute zonal occult outer retinopathy (AZOOR), a rare white dot syndrome of unknown etiology, associated with damage to the large zones of the outer retina. Recently, it has been established that epileptic episodes contribute to an inflammatory response both in the brain and the retina. A 13-year-old male patient with epilepsy was referred by a neurologist for an ophthalmologic consultation due to a sudden deterioration of visual acuity in the left eye. The examination, with a key role of multimodal imaging including color fundus photography, fluorescein angiography, indocyanine green angiography (ICGA), fundus autofluorescence (FAF), swept-source optical coherence tomography (SS-OCT) with visual field assessment, and electroretinography indicated AZOOR as the underlying entity. Findings at the first admission included enlargement of the blind spot in visual field examination along a typical trizonal pattern, which was revealed by FAF, ICGA, and SS-OCT in the left eye. The right eye exhibited no abnormalities. Seminal follow-up revealed no changes in best corrected visual acuity, and multimodal imaging findings remain unaltered. Thus, no medical intervention is required. Our case and recent laboratory findings suggest a causative link between epilepsy and retinal disorders, although this issue requires further research.
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spelling pubmed-86240972021-11-27 Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up Karska-Basta, Izabella Romanowska-Dixon, Bożena Pojda-Wilczek, Dorota Bakunowicz-Łazarczyk, Alina Kubicka-Trząska, Agnieszka Gerba-Górecka, Karolina Medicina (Kaunas) Case Report We report an unprecedented case of a young patient with epilepsy coexisting with acute zonal occult outer retinopathy (AZOOR), a rare white dot syndrome of unknown etiology, associated with damage to the large zones of the outer retina. Recently, it has been established that epileptic episodes contribute to an inflammatory response both in the brain and the retina. A 13-year-old male patient with epilepsy was referred by a neurologist for an ophthalmologic consultation due to a sudden deterioration of visual acuity in the left eye. The examination, with a key role of multimodal imaging including color fundus photography, fluorescein angiography, indocyanine green angiography (ICGA), fundus autofluorescence (FAF), swept-source optical coherence tomography (SS-OCT) with visual field assessment, and electroretinography indicated AZOOR as the underlying entity. Findings at the first admission included enlargement of the blind spot in visual field examination along a typical trizonal pattern, which was revealed by FAF, ICGA, and SS-OCT in the left eye. The right eye exhibited no abnormalities. Seminal follow-up revealed no changes in best corrected visual acuity, and multimodal imaging findings remain unaltered. Thus, no medical intervention is required. Our case and recent laboratory findings suggest a causative link between epilepsy and retinal disorders, although this issue requires further research. MDPI 2021-11-20 /pmc/articles/PMC8624097/ /pubmed/34833494 http://dx.doi.org/10.3390/medicina57111276 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Karska-Basta, Izabella
Romanowska-Dixon, Bożena
Pojda-Wilczek, Dorota
Bakunowicz-Łazarczyk, Alina
Kubicka-Trząska, Agnieszka
Gerba-Górecka, Karolina
Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up
title Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up
title_full Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up
title_fullStr Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up
title_full_unstemmed Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up
title_short Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up
title_sort acute zonal occult outer retinopathy in a patient suffering from epilepsy: five-year follow-up
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624097/
https://www.ncbi.nlm.nih.gov/pubmed/34833494
http://dx.doi.org/10.3390/medicina57111276
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