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Epidemiological and Immunological Features of Obesity and SARS-CoV-2
Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response remain poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demog...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624148/ https://www.ncbi.nlm.nih.gov/pubmed/34835041 http://dx.doi.org/10.3390/v13112235 |
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author | Nilles, Eric J. Siddiqui, Sameed M. Fischinger, Stephanie Bartsch, Yannic C. de St. Aubin, Michael Zhou, Guohai Gluck, Matthew J. Berger, Samuel Rhee, Justin Petersen, Eric Mormann, Benjamin Loesche, Michael Hu, Yiyuan Chen, Zhilin Yu, Jingyou Gebre, Makda Atyeo, Caroline Gorman, Matthew J. Zhu, Alex Lee Burke, John Slein, Matthew Hasdianda, Mohammad A. Jambaulikar, Guruprasad Boyer, Edward W. Sabeti, Pardis C. Barouch, Dan H. Julg, Boris Kucharski, Adam J. Musk, Elon R. Lauffenburger, Douglas A. Alter, Galit Menon, Anil S. |
author_facet | Nilles, Eric J. Siddiqui, Sameed M. Fischinger, Stephanie Bartsch, Yannic C. de St. Aubin, Michael Zhou, Guohai Gluck, Matthew J. Berger, Samuel Rhee, Justin Petersen, Eric Mormann, Benjamin Loesche, Michael Hu, Yiyuan Chen, Zhilin Yu, Jingyou Gebre, Makda Atyeo, Caroline Gorman, Matthew J. Zhu, Alex Lee Burke, John Slein, Matthew Hasdianda, Mohammad A. Jambaulikar, Guruprasad Boyer, Edward W. Sabeti, Pardis C. Barouch, Dan H. Julg, Boris Kucharski, Adam J. Musk, Elon R. Lauffenburger, Douglas A. Alter, Galit Menon, Anil S. |
author_sort | Nilles, Eric J. |
collection | PubMed |
description | Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response remain poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, and prior COVID-19 compatible symptoms were assessed at baseline and serostatus and symptoms monthly thereafter. SARS-CoV-2 immunoassays included an IgG ELISA targeting the spike RBD, multiarray Luminex targeting 20 viral antigens, pseudovirus neutralization, and T cell ELISPOT assays. Our results from a large prospective SARS-CoV-2 cohort study indicate symptom phenotype is strongly influenced by obesity among younger but not older age groups; we did not identify evidence to suggest obese individuals are at higher risk of SARS-CoV-2 infection; and remarkably homogenous immune activity across BMI categories suggests immune protection across these groups may be similar. |
format | Online Article Text |
id | pubmed-8624148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86241482021-11-27 Epidemiological and Immunological Features of Obesity and SARS-CoV-2 Nilles, Eric J. Siddiqui, Sameed M. Fischinger, Stephanie Bartsch, Yannic C. de St. Aubin, Michael Zhou, Guohai Gluck, Matthew J. Berger, Samuel Rhee, Justin Petersen, Eric Mormann, Benjamin Loesche, Michael Hu, Yiyuan Chen, Zhilin Yu, Jingyou Gebre, Makda Atyeo, Caroline Gorman, Matthew J. Zhu, Alex Lee Burke, John Slein, Matthew Hasdianda, Mohammad A. Jambaulikar, Guruprasad Boyer, Edward W. Sabeti, Pardis C. Barouch, Dan H. Julg, Boris Kucharski, Adam J. Musk, Elon R. Lauffenburger, Douglas A. Alter, Galit Menon, Anil S. Viruses Article Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response remain poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, and prior COVID-19 compatible symptoms were assessed at baseline and serostatus and symptoms monthly thereafter. SARS-CoV-2 immunoassays included an IgG ELISA targeting the spike RBD, multiarray Luminex targeting 20 viral antigens, pseudovirus neutralization, and T cell ELISPOT assays. Our results from a large prospective SARS-CoV-2 cohort study indicate symptom phenotype is strongly influenced by obesity among younger but not older age groups; we did not identify evidence to suggest obese individuals are at higher risk of SARS-CoV-2 infection; and remarkably homogenous immune activity across BMI categories suggests immune protection across these groups may be similar. MDPI 2021-11-06 /pmc/articles/PMC8624148/ /pubmed/34835041 http://dx.doi.org/10.3390/v13112235 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nilles, Eric J. Siddiqui, Sameed M. Fischinger, Stephanie Bartsch, Yannic C. de St. Aubin, Michael Zhou, Guohai Gluck, Matthew J. Berger, Samuel Rhee, Justin Petersen, Eric Mormann, Benjamin Loesche, Michael Hu, Yiyuan Chen, Zhilin Yu, Jingyou Gebre, Makda Atyeo, Caroline Gorman, Matthew J. Zhu, Alex Lee Burke, John Slein, Matthew Hasdianda, Mohammad A. Jambaulikar, Guruprasad Boyer, Edward W. Sabeti, Pardis C. Barouch, Dan H. Julg, Boris Kucharski, Adam J. Musk, Elon R. Lauffenburger, Douglas A. Alter, Galit Menon, Anil S. Epidemiological and Immunological Features of Obesity and SARS-CoV-2 |
title | Epidemiological and Immunological Features of Obesity and SARS-CoV-2 |
title_full | Epidemiological and Immunological Features of Obesity and SARS-CoV-2 |
title_fullStr | Epidemiological and Immunological Features of Obesity and SARS-CoV-2 |
title_full_unstemmed | Epidemiological and Immunological Features of Obesity and SARS-CoV-2 |
title_short | Epidemiological and Immunological Features of Obesity and SARS-CoV-2 |
title_sort | epidemiological and immunological features of obesity and sars-cov-2 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624148/ https://www.ncbi.nlm.nih.gov/pubmed/34835041 http://dx.doi.org/10.3390/v13112235 |
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