Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination

The Fanconi anemia (FA) DNA repair pathway coordinates a faithful repair mechanism for stalled DNA replication forks caused by factors such as DNA interstrand crosslinks (ICLs) or replication stress. An important role of FA pathway activation is initiated by monoubiquitination of FANCD2 and its bind...

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Autor principal: Ishiai, Masamichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624177/
https://www.ncbi.nlm.nih.gov/pubmed/34828369
http://dx.doi.org/10.3390/genes12111763
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author Ishiai, Masamichi
author_facet Ishiai, Masamichi
author_sort Ishiai, Masamichi
collection PubMed
description The Fanconi anemia (FA) DNA repair pathway coordinates a faithful repair mechanism for stalled DNA replication forks caused by factors such as DNA interstrand crosslinks (ICLs) or replication stress. An important role of FA pathway activation is initiated by monoubiquitination of FANCD2 and its binding partner of FANCI, which is regulated by the ATM-related kinase, ATR. Therefore, regulation of the FA pathway is a good example of the contribution of ATR to genome stability. In this short review, we summarize the knowledge accumulated over the years regarding how the FA pathway is activated via phosphorylation and monoubiquitination.
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spelling pubmed-86241772021-11-27 Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination Ishiai, Masamichi Genes (Basel) Review The Fanconi anemia (FA) DNA repair pathway coordinates a faithful repair mechanism for stalled DNA replication forks caused by factors such as DNA interstrand crosslinks (ICLs) or replication stress. An important role of FA pathway activation is initiated by monoubiquitination of FANCD2 and its binding partner of FANCI, which is regulated by the ATM-related kinase, ATR. Therefore, regulation of the FA pathway is a good example of the contribution of ATR to genome stability. In this short review, we summarize the knowledge accumulated over the years regarding how the FA pathway is activated via phosphorylation and monoubiquitination. MDPI 2021-11-05 /pmc/articles/PMC8624177/ /pubmed/34828369 http://dx.doi.org/10.3390/genes12111763 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ishiai, Masamichi
Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination
title Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination
title_full Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination
title_fullStr Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination
title_full_unstemmed Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination
title_short Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination
title_sort regulation of the fanconi anemia dna repair pathway by phosphorylation and monoubiquitination
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624177/
https://www.ncbi.nlm.nih.gov/pubmed/34828369
http://dx.doi.org/10.3390/genes12111763
work_keys_str_mv AT ishiaimasamichi regulationofthefanconianemiadnarepairpathwaybyphosphorylationandmonoubiquitination

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