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Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is the most prevalent oral malignant tumor worldwide. An early diagnosis can have a major positive impact on its prognosis. Human saliva contains cytokines, DNA and RNA molecules, circulating cells, and derivatives of tissues and extracellular vesicles, among othe...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624198/ https://www.ncbi.nlm.nih.gov/pubmed/34830096 http://dx.doi.org/10.3390/ijms222212215 |
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author | Manzano-Moreno, Francisco Javier Costela-Ruiz, Victor J. García-Recio, Enrique Olmedo-Gaya, Maria Victoria Ruiz, Concepción Reyes-Botella, Candelaria |
author_facet | Manzano-Moreno, Francisco Javier Costela-Ruiz, Victor J. García-Recio, Enrique Olmedo-Gaya, Maria Victoria Ruiz, Concepción Reyes-Botella, Candelaria |
author_sort | Manzano-Moreno, Francisco Javier |
collection | PubMed |
description | Oral squamous cell carcinoma (OSCC) is the most prevalent oral malignant tumor worldwide. An early diagnosis can have a major positive impact on its prognosis. Human saliva contains cytokines, DNA and RNA molecules, circulating cells, and derivatives of tissues and extracellular vesicles, among other factors that can serve as biomarkers. Hence, the analysis of saliva may provide useful information for the early diagnosis of OSCC for its prognosis. The objective of this review was to determine the potential usefulness of salivary biomarkers (cytokines and microRNA) to diagnose OSCC and improve its prognosis. A combination of salivary miRNA and proteomic data could allow a definitive and early diagnosis to be obtained. However, there remains a need to optimize and standardize the protocols used to quantify miRNAs. |
format | Online Article Text |
id | pubmed-8624198 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86241982021-11-27 Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma Manzano-Moreno, Francisco Javier Costela-Ruiz, Victor J. García-Recio, Enrique Olmedo-Gaya, Maria Victoria Ruiz, Concepción Reyes-Botella, Candelaria Int J Mol Sci Review Oral squamous cell carcinoma (OSCC) is the most prevalent oral malignant tumor worldwide. An early diagnosis can have a major positive impact on its prognosis. Human saliva contains cytokines, DNA and RNA molecules, circulating cells, and derivatives of tissues and extracellular vesicles, among other factors that can serve as biomarkers. Hence, the analysis of saliva may provide useful information for the early diagnosis of OSCC for its prognosis. The objective of this review was to determine the potential usefulness of salivary biomarkers (cytokines and microRNA) to diagnose OSCC and improve its prognosis. A combination of salivary miRNA and proteomic data could allow a definitive and early diagnosis to be obtained. However, there remains a need to optimize and standardize the protocols used to quantify miRNAs. MDPI 2021-11-11 /pmc/articles/PMC8624198/ /pubmed/34830096 http://dx.doi.org/10.3390/ijms222212215 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Manzano-Moreno, Francisco Javier Costela-Ruiz, Victor J. García-Recio, Enrique Olmedo-Gaya, Maria Victoria Ruiz, Concepción Reyes-Botella, Candelaria Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma |
title | Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma |
title_full | Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma |
title_fullStr | Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma |
title_full_unstemmed | Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma |
title_short | Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma |
title_sort | role of salivary microrna and cytokines in the diagnosis and prognosis of oral squamous cell carcinoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624198/ https://www.ncbi.nlm.nih.gov/pubmed/34830096 http://dx.doi.org/10.3390/ijms222212215 |
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