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Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma

Oral squamous cell carcinoma (OSCC) is the most prevalent oral malignant tumor worldwide. An early diagnosis can have a major positive impact on its prognosis. Human saliva contains cytokines, DNA and RNA molecules, circulating cells, and derivatives of tissues and extracellular vesicles, among othe...

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Autores principales: Manzano-Moreno, Francisco Javier, Costela-Ruiz, Victor J., García-Recio, Enrique, Olmedo-Gaya, Maria Victoria, Ruiz, Concepción, Reyes-Botella, Candelaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624198/
https://www.ncbi.nlm.nih.gov/pubmed/34830096
http://dx.doi.org/10.3390/ijms222212215
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author Manzano-Moreno, Francisco Javier
Costela-Ruiz, Victor J.
García-Recio, Enrique
Olmedo-Gaya, Maria Victoria
Ruiz, Concepción
Reyes-Botella, Candelaria
author_facet Manzano-Moreno, Francisco Javier
Costela-Ruiz, Victor J.
García-Recio, Enrique
Olmedo-Gaya, Maria Victoria
Ruiz, Concepción
Reyes-Botella, Candelaria
author_sort Manzano-Moreno, Francisco Javier
collection PubMed
description Oral squamous cell carcinoma (OSCC) is the most prevalent oral malignant tumor worldwide. An early diagnosis can have a major positive impact on its prognosis. Human saliva contains cytokines, DNA and RNA molecules, circulating cells, and derivatives of tissues and extracellular vesicles, among other factors that can serve as biomarkers. Hence, the analysis of saliva may provide useful information for the early diagnosis of OSCC for its prognosis. The objective of this review was to determine the potential usefulness of salivary biomarkers (cytokines and microRNA) to diagnose OSCC and improve its prognosis. A combination of salivary miRNA and proteomic data could allow a definitive and early diagnosis to be obtained. However, there remains a need to optimize and standardize the protocols used to quantify miRNAs.
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spelling pubmed-86241982021-11-27 Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma Manzano-Moreno, Francisco Javier Costela-Ruiz, Victor J. García-Recio, Enrique Olmedo-Gaya, Maria Victoria Ruiz, Concepción Reyes-Botella, Candelaria Int J Mol Sci Review Oral squamous cell carcinoma (OSCC) is the most prevalent oral malignant tumor worldwide. An early diagnosis can have a major positive impact on its prognosis. Human saliva contains cytokines, DNA and RNA molecules, circulating cells, and derivatives of tissues and extracellular vesicles, among other factors that can serve as biomarkers. Hence, the analysis of saliva may provide useful information for the early diagnosis of OSCC for its prognosis. The objective of this review was to determine the potential usefulness of salivary biomarkers (cytokines and microRNA) to diagnose OSCC and improve its prognosis. A combination of salivary miRNA and proteomic data could allow a definitive and early diagnosis to be obtained. However, there remains a need to optimize and standardize the protocols used to quantify miRNAs. MDPI 2021-11-11 /pmc/articles/PMC8624198/ /pubmed/34830096 http://dx.doi.org/10.3390/ijms222212215 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Manzano-Moreno, Francisco Javier
Costela-Ruiz, Victor J.
García-Recio, Enrique
Olmedo-Gaya, Maria Victoria
Ruiz, Concepción
Reyes-Botella, Candelaria
Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma
title Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma
title_full Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma
title_fullStr Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma
title_full_unstemmed Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma
title_short Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma
title_sort role of salivary microrna and cytokines in the diagnosis and prognosis of oral squamous cell carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624198/
https://www.ncbi.nlm.nih.gov/pubmed/34830096
http://dx.doi.org/10.3390/ijms222212215
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