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Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021

The recognition of biomolecules is crucial in key areas such as the timely diagnosis of somatic and infectious diseases, food quality control, and environmental monitoring. This determines the need to develop highly sensitive display devices based on the achievements of modern science and technology...

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Autores principales: Rudenko, Natalia, Fursova, Ksenia, Shepelyakovskaya, Anna, Karatovskaya, Anna, Brovko, Fedor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624206/
https://www.ncbi.nlm.nih.gov/pubmed/34833687
http://dx.doi.org/10.3390/s21227614
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author Rudenko, Natalia
Fursova, Ksenia
Shepelyakovskaya, Anna
Karatovskaya, Anna
Brovko, Fedor
author_facet Rudenko, Natalia
Fursova, Ksenia
Shepelyakovskaya, Anna
Karatovskaya, Anna
Brovko, Fedor
author_sort Rudenko, Natalia
collection PubMed
description The recognition of biomolecules is crucial in key areas such as the timely diagnosis of somatic and infectious diseases, food quality control, and environmental monitoring. This determines the need to develop highly sensitive display devices based on the achievements of modern science and technology, characterized by high selectivity, high speed, low cost, availability, and small size. Such requirements are met by biosensor systems—devices for reagent-free analysis of compounds that consist of a biologically sensitive element (receptor), a transducer, and a working solution. The diversity of biological material and methods for its immobilization on the surface or in the volume of the transducer and the use of nanotechnologies have led to the appearance of an avalanche-like number of different biosensors, which, depending on the type of biologically sensitive element, can be divided into three groups: enzyme, affinity, and cellular/tissue. Affinity biosensors are one of the rapidly developing areas in immunoassay, where the key point is to register the formation of an antigen–antibody complex. This review analyzes the latest work by Russian researchers concerning the production of molecules used in various immunoassay formats as well as new fundamental scientific data obtained as a result of their use.
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spelling pubmed-86242062021-11-27 Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021 Rudenko, Natalia Fursova, Ksenia Shepelyakovskaya, Anna Karatovskaya, Anna Brovko, Fedor Sensors (Basel) Review The recognition of biomolecules is crucial in key areas such as the timely diagnosis of somatic and infectious diseases, food quality control, and environmental monitoring. This determines the need to develop highly sensitive display devices based on the achievements of modern science and technology, characterized by high selectivity, high speed, low cost, availability, and small size. Such requirements are met by biosensor systems—devices for reagent-free analysis of compounds that consist of a biologically sensitive element (receptor), a transducer, and a working solution. The diversity of biological material and methods for its immobilization on the surface or in the volume of the transducer and the use of nanotechnologies have led to the appearance of an avalanche-like number of different biosensors, which, depending on the type of biologically sensitive element, can be divided into three groups: enzyme, affinity, and cellular/tissue. Affinity biosensors are one of the rapidly developing areas in immunoassay, where the key point is to register the formation of an antigen–antibody complex. This review analyzes the latest work by Russian researchers concerning the production of molecules used in various immunoassay formats as well as new fundamental scientific data obtained as a result of their use. MDPI 2021-11-16 /pmc/articles/PMC8624206/ /pubmed/34833687 http://dx.doi.org/10.3390/s21227614 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rudenko, Natalia
Fursova, Ksenia
Shepelyakovskaya, Anna
Karatovskaya, Anna
Brovko, Fedor
Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021
title Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021
title_full Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021
title_fullStr Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021
title_full_unstemmed Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021
title_short Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021
title_sort antibodies as biosensors’ key components: state-of-the-art in russia 2020–2021
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624206/
https://www.ncbi.nlm.nih.gov/pubmed/34833687
http://dx.doi.org/10.3390/s21227614
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