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Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study
Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing this evolution. Methods: The CORDIOPREV study is a randomized, long-term secondar...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624211/ https://www.ncbi.nlm.nih.gov/pubmed/34836298 http://dx.doi.org/10.3390/nu13114046 |
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author | Martin-Piedra, Laura Alcala-Diaz, Juan F. Gutierrez-Mariscal, Francisco M. Arenas de Larriva, Antonio P. Romero-Cabrera, Juan L. Torres-Peña, Jose D. Caballero-Villarraso, Javier Luque, Raul M. Perez-Martinez, Pablo Lopez-Miranda, Jose Delgado-Lista, Javier |
author_facet | Martin-Piedra, Laura Alcala-Diaz, Juan F. Gutierrez-Mariscal, Francisco M. Arenas de Larriva, Antonio P. Romero-Cabrera, Juan L. Torres-Peña, Jose D. Caballero-Villarraso, Javier Luque, Raul M. Perez-Martinez, Pablo Lopez-Miranda, Jose Delgado-Lista, Javier |
author_sort | Martin-Piedra, Laura |
collection | PubMed |
description | Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing this evolution. Methods: The CORDIOPREV study is a randomized, long-term secondary prevention study with two healthy diets: Mediterranean and low-fat. All obese patients were classified as either metabolically healthy obese (MHO) or metabolically unhealthy obese (MUO). We evaluated the changes in the metabolic phenotypes and related variables after 5 years of dietary intervention. Results: Initially, 562 out of the 1002 CORDIOPREV patients were obese. After 5 years, 476 obese patients maintained their clinical and dietary visits; 71.8% of MHO patients changed to unhealthy phenotypes (MHO-Progressors), whereas the MHO patients who maintained healthy phenotypes (MHO-Non-Progressors) lost more in terms of their body mass index (BMI) and had a lower fatty liver index (FLI-score) (p < 0.05). Most of the MUO (92%) patients maintained unhealthy phenotypes (MUO-Non-Responders), but 8% became metabolically healthy (MUO-Responders) after a significant decrease in their BMI and FLI-score, with improvement in all metabolic criteria. No differences were found among dietary groups. Conclusions: A greater loss of weight and liver fat is associated with a lower progression of the MHO phenotype to unhealthy phenotypes. Likewise, a marked improvement in these parameters is associated with regression from MUO to healthy phenotypes. |
format | Online Article Text |
id | pubmed-8624211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86242112021-11-27 Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study Martin-Piedra, Laura Alcala-Diaz, Juan F. Gutierrez-Mariscal, Francisco M. Arenas de Larriva, Antonio P. Romero-Cabrera, Juan L. Torres-Peña, Jose D. Caballero-Villarraso, Javier Luque, Raul M. Perez-Martinez, Pablo Lopez-Miranda, Jose Delgado-Lista, Javier Nutrients Article Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing this evolution. Methods: The CORDIOPREV study is a randomized, long-term secondary prevention study with two healthy diets: Mediterranean and low-fat. All obese patients were classified as either metabolically healthy obese (MHO) or metabolically unhealthy obese (MUO). We evaluated the changes in the metabolic phenotypes and related variables after 5 years of dietary intervention. Results: Initially, 562 out of the 1002 CORDIOPREV patients were obese. After 5 years, 476 obese patients maintained their clinical and dietary visits; 71.8% of MHO patients changed to unhealthy phenotypes (MHO-Progressors), whereas the MHO patients who maintained healthy phenotypes (MHO-Non-Progressors) lost more in terms of their body mass index (BMI) and had a lower fatty liver index (FLI-score) (p < 0.05). Most of the MUO (92%) patients maintained unhealthy phenotypes (MUO-Non-Responders), but 8% became metabolically healthy (MUO-Responders) after a significant decrease in their BMI and FLI-score, with improvement in all metabolic criteria. No differences were found among dietary groups. Conclusions: A greater loss of weight and liver fat is associated with a lower progression of the MHO phenotype to unhealthy phenotypes. Likewise, a marked improvement in these parameters is associated with regression from MUO to healthy phenotypes. MDPI 2021-11-12 /pmc/articles/PMC8624211/ /pubmed/34836298 http://dx.doi.org/10.3390/nu13114046 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Martin-Piedra, Laura Alcala-Diaz, Juan F. Gutierrez-Mariscal, Francisco M. Arenas de Larriva, Antonio P. Romero-Cabrera, Juan L. Torres-Peña, Jose D. Caballero-Villarraso, Javier Luque, Raul M. Perez-Martinez, Pablo Lopez-Miranda, Jose Delgado-Lista, Javier Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study |
title | Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study |
title_full | Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study |
title_fullStr | Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study |
title_full_unstemmed | Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study |
title_short | Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study |
title_sort | evolution of metabolic phenotypes of obesity in coronary patients after 5 years of dietary intervention: from the cordioprev study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624211/ https://www.ncbi.nlm.nih.gov/pubmed/34836298 http://dx.doi.org/10.3390/nu13114046 |
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