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The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer
IL6-like cytokines are a family of regulators with a complex, pleiotropic role in both the healthy organism, where they regulate immunity and homeostasis, and in different diseases, including cancer. Here we summarise how these cytokines exert their effect through the shared signal transducer IL6ST...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624266/ https://www.ncbi.nlm.nih.gov/pubmed/34834425 http://dx.doi.org/10.3390/jpm11111073 |
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author | Martínez-Pérez, Carlos Kay, Charlene Meehan, James Gray, Mark Dixon, J. Michael Turnbull, Arran K. |
author_facet | Martínez-Pérez, Carlos Kay, Charlene Meehan, James Gray, Mark Dixon, J. Michael Turnbull, Arran K. |
author_sort | Martínez-Pérez, Carlos |
collection | PubMed |
description | IL6-like cytokines are a family of regulators with a complex, pleiotropic role in both the healthy organism, where they regulate immunity and homeostasis, and in different diseases, including cancer. Here we summarise how these cytokines exert their effect through the shared signal transducer IL6ST (gp130) and we review the extensive evidence on the role that different members of this family play in breast cancer. Additionally, we discuss how the different cytokines, their related receptors and downstream effectors, as well as specific polymorphisms in these molecules, can serve as predictive or prognostic biomarkers with the potential for clinical application in breast cancer. Lastly, we also discuss how our increasing understanding of this complex signalling axis presents promising opportunities for the development or repurposing of therapeutic strategies against cancer and, specifically, breast neoplasms. |
format | Online Article Text |
id | pubmed-8624266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86242662021-11-27 The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer Martínez-Pérez, Carlos Kay, Charlene Meehan, James Gray, Mark Dixon, J. Michael Turnbull, Arran K. J Pers Med Review IL6-like cytokines are a family of regulators with a complex, pleiotropic role in both the healthy organism, where they regulate immunity and homeostasis, and in different diseases, including cancer. Here we summarise how these cytokines exert their effect through the shared signal transducer IL6ST (gp130) and we review the extensive evidence on the role that different members of this family play in breast cancer. Additionally, we discuss how the different cytokines, their related receptors and downstream effectors, as well as specific polymorphisms in these molecules, can serve as predictive or prognostic biomarkers with the potential for clinical application in breast cancer. Lastly, we also discuss how our increasing understanding of this complex signalling axis presents promising opportunities for the development or repurposing of therapeutic strategies against cancer and, specifically, breast neoplasms. MDPI 2021-10-24 /pmc/articles/PMC8624266/ /pubmed/34834425 http://dx.doi.org/10.3390/jpm11111073 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Martínez-Pérez, Carlos Kay, Charlene Meehan, James Gray, Mark Dixon, J. Michael Turnbull, Arran K. The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer |
title | The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer |
title_full | The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer |
title_fullStr | The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer |
title_full_unstemmed | The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer |
title_short | The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer |
title_sort | il6-like cytokine family: role and biomarker potential in breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624266/ https://www.ncbi.nlm.nih.gov/pubmed/34834425 http://dx.doi.org/10.3390/jpm11111073 |
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