Cargando…

Opposing Immune-Metabolic Signature in Visceral Versus Subcutaneous Adipose Tissue in Patients with Adenocarcinoma of the Oesophagus and the Oesophagogastric Junction

Oesophageal adenocarcinoma (OAC) is an exemplar model of obesity-associated cancer. Previous work in our group has demonstrated that overweight/obese OAC patients have better responses to neoadjuvant therapy, but the underlying mechanisms are unknown. Unravelling the immune–metabolic signatures of a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Heeran, Aisling B., McCready, Jessica, Dunne, Margaret R., Donlon, Noel E., Nugent, Timothy S., Bhardwaj, Anshul, Mitchelson, Kathleen A. J., Buckley, Amy M., Ravi, Narayanasamy, Roche, Helen M., Reynolds, John V., Lynam-Lennon, Niamh, O’Sullivan, Jacintha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624269/ https://www.ncbi.nlm.nih.gov/pubmed/34822426 http://dx.doi.org/10.3390/metabo11110768

Ejemplares similares

Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma
por: Donlon, Noel E, et al.
Publicado: (2022)

The Protein Secretome Is Altered in Rectal Cancer Tissue Compared to Normal Rectal Tissue, and Alterations in the Secretome Induce Enhanced Innate Immune Responses
por: Heeran, Aisling B., et al.
Publicado: (2021)

Radiation-induced Bystander Effect (RIBE) alters mitochondrial metabolism using a human rectal cancer ex vivo explant model
por: Heeran, Aisling B., et al.
Publicado: (2020)

FLOT and CROSS chemotherapy regimens alter the frequency of CD27(+) and CD69(+) T cells in oesophagogastric adenocarcinomas: implications for combination with immunotherapy
por: Davern, Maria, et al.
Publicado: (2022)

Potential of damage associated molecular patterns in synergising radiation and the immune response in oesophageal cancer
por: Donlon, Noel E, et al.
Publicado: (2023)

The Prognostic Value of the Lymph Node in Oesophageal Adenocarcinoma; Incorporating Clinicopathological and Immunological Profiling
por: Donlon, Noel E., et al.
Publicado: (2021)

Leukaemia inhibitory factor is associated with treatment resistance in oesophageal adenocarcinoma
por: Buckley, Amy M., et al.
Publicado: (2018)

Energy Metabolism, Metabolite, and Inflammatory Profiles in Human Ex Vivo Adipose Tissue Are Influenced by Obesity Status, Metabolic Dysfunction, and Treatment Regimes in Patients with Oesophageal Adenocarcinoma
por: O’Connell, Fiona, et al.
Publicado: (2023)

PD-1 blockade attenuates surgery-mediated immunosuppression and boosts Th1 immunity perioperatively in oesophagogastric junctional adenocarcinoma
por: Davern, Maria, et al.
Publicado: (2023)

Chemotherapy regimens induce inhibitory immune checkpoint protein expression on stem-like and senescent-like oesophageal adenocarcinoma cells
por: Davern, Maria, et al.
Publicado: (2021)

Energy Metabolism Is Altered in Radioresistant Rectal Cancer
por: Buckley, Croí E., et al.
Publicado: (2023)

Visceral adipose tissue secretome from early and late-stage oesophageal cancer patients differentially affects effector and regulatory T cells
por: Davern, Maria, et al.
Publicado: (2023)

Prognostic, Diagnostic and Predictive Biomarkers in the Barrett’s Oesophagus-Adenocarcinoma Disease Sequence
por: O’Dowd, Darragh, et al.
Publicado: (2022)

Altered Mitochondrial Function and Energy Metabolism Is Associated with a Radioresistant Phenotype in Oesophageal Adenocarcinoma
por: Lynam-Lennon, Niamh, et al.
Publicado: (2014)

ICORG 10-14: NEOadjuvant trial in Adenocarcinoma of the oEsophagus and oesophagoGastric junction International Study (Neo-AEGIS)
por: Reynolds, JV, et al.
Publicado: (2017)

Metformin is a metabolic modulator and radiosensitiser in rectal cancer
por: Buckley, Croí E., et al.
Publicado: (2023)

Visceral Adipose Tissue Modulates Radiosensitivity in Oesophageal Adenocarcinoma
por: Mongan, Ann Marie, et al.
Publicado: (2019)

Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial
por: Reynolds, John V, et al.
Publicado: (2023)

Resection of oesophageal and oesophagogastric junction cancer liver metastases — a summary of current evidence
por: Weiss, Andreas R. R., et al.
Publicado: (2021)

Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma
por: Lynam-Lennon, Niamh, et al.
Publicado: (2014)

PD-1 and TIGIT blockade differentially affect tumour cell survival under hypoxia and glucose deprived conditions in oesophageal adenocarcinoma; implications for overcoming resistance to PD-1 blockade in hypoxic tumours
por: Davern, Maria, et al.
Publicado: (2022)

Linking Circulating Serum Proteins with Clinical Outcomes in Esophageal Adenocarcinoma—An Emerging Role for Chemokines
por: Donlon, Noel E., et al.
Publicado: (2020)

Rehabilitation strategies following oesophagogastric and Hepatopancreaticobiliary cancer (ReStOre II): a protocol for a randomized controlled trial
por: O’Neill, Linda, et al.
Publicado: (2020)

The Impact of Esophageal Oncological Surgery on Perioperative Immune Function; Implications for Adjuvant Immune Checkpoint Inhibition
por: Donlon, Noel E., et al.
Publicado: (2022)

Precision Medicine and Novel Therapeutic Strategies in Detection and Treatment of Cancer: Highlights from the 58th IACR Annual Conference
por: Kennedy, Sean P., et al.
Publicado: (2022)

The evolving immunotherapeutic landscape in advanced oesophagogastric cancer
por: Flynn, Michael, et al.
Publicado: (2018)

The tumour microenvironment of the upper and lower gastrointestinal tract differentially influences dendritic cell maturation
por: Morrissey, Maria E., et al.
Publicado: (2020)

PD-1 blockade enhances chemotherapy toxicity in oesophageal adenocarcinoma
por: Davern, Maria, et al.
Publicado: (2022)

Perioperative Therapy of Oesophagogastric Adenocarcinoma: Mainstay and Future Directions
por: Bose, Katrin, et al.
Publicado: (2017)

Thinking inside the box: intracellular roles for complement system proteins come into focus
por: O’Brien, Rebecca M., et al.
Publicado: (2023)

Carcinoma of the oesophagus
por: Seitz, J F, et al.
Publicado: (2001)

Stricture of the Œsophagus
Publicado: (1901)

Rupture of the Œsophagus
Publicado: (1900)

Rupture of Œsophagus
Publicado: (1933)

Spasm of the Œsophagus
Publicado: (1881)

Rupture of the Œsophagus
por: Colegrove, C.
Publicado: (1849)

On Polypus of the Œsophagus
Publicado: (1859)

Diverticulum of the Œsophagus
por: Clement, A. W.
Publicado: (1891)

Polypus of the Œsophagus
por: Everett, J. T.
Publicado: (1871)

Case of Aneurism of the Aorta Simulating Phthisis
por: McCready, W. B.
Publicado: (1852)

Cannot write session to /tmp/vufind_sessions/sess_1b5sspj44qqtnu8j8p25stnmhi