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Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy

Background and Objectives: The aim of this study was to evaluate longitudinal changes using both upper limb muscle Magnetic Resonance Imaging (MRI) at shoulder, arm and forearm levels and Performance of upper limb (PUL) in ambulant and non-ambulant Duchenne Muscular Dystrophy (DMD) patients. We also...

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Autores principales: Brogna, Claudia, Cristiano, Lara, Verdolotti, Tommaso, Norcia, Giulia, Ficociello, Luana, Ruiz, Roberta, Coratti, Giorgia, Fanelli, Lavinia, Forcina, Nicola, Petracca, Giorgia, Chieppa, Fabrizia, Tartaglione, Tommaso, Colosimo, Cesare, Pane, Marika, Mercuri, Eugenio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624281/
https://www.ncbi.nlm.nih.gov/pubmed/34833484
http://dx.doi.org/10.3390/medicina57111267
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author Brogna, Claudia
Cristiano, Lara
Verdolotti, Tommaso
Norcia, Giulia
Ficociello, Luana
Ruiz, Roberta
Coratti, Giorgia
Fanelli, Lavinia
Forcina, Nicola
Petracca, Giorgia
Chieppa, Fabrizia
Tartaglione, Tommaso
Colosimo, Cesare
Pane, Marika
Mercuri, Eugenio
author_facet Brogna, Claudia
Cristiano, Lara
Verdolotti, Tommaso
Norcia, Giulia
Ficociello, Luana
Ruiz, Roberta
Coratti, Giorgia
Fanelli, Lavinia
Forcina, Nicola
Petracca, Giorgia
Chieppa, Fabrizia
Tartaglione, Tommaso
Colosimo, Cesare
Pane, Marika
Mercuri, Eugenio
author_sort Brogna, Claudia
collection PubMed
description Background and Objectives: The aim of this study was to evaluate longitudinal changes using both upper limb muscle Magnetic Resonance Imaging (MRI) at shoulder, arm and forearm levels and Performance of upper limb (PUL) in ambulant and non-ambulant Duchenne Muscular Dystrophy (DMD) patients. We also wished to define whether baseline muscle MRI could help to predict functional changes after one year. Materials and Methods: Twenty-seven patients had both baseline and 12month muscle MRI and PUL assessments one year later. Results: Ten were ambulant (age range 5–16 years), and 17 non ambulant (age range 10–30 years). Increased abnormalities equal or more than 1.5 point on muscle MRI at follow up were found on all domains: at shoulder level 12/27 patients (44%), at arm level 4/27 (15%) and at forearm level 6/27 (22%). Lower follow up PUL score were found in 8/27 patients (30%) at shoulder level, in 9/27 patients (33%) at mid-level whereas no functional changes were found at distal level. There was no constant association between baseline MRI scores and follow up PUL scores at arm and forearm levels but at shoulder level patients with moderate impairment on the baseline MRI scores between 16 and 34 had the highest risk of decreased function on PUL over a year. Conclusions: Our results confirmed that the integrated use of functional scales and imaging can help to monitor functional and MRI changes over time.
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spelling pubmed-86242812021-11-27 Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy Brogna, Claudia Cristiano, Lara Verdolotti, Tommaso Norcia, Giulia Ficociello, Luana Ruiz, Roberta Coratti, Giorgia Fanelli, Lavinia Forcina, Nicola Petracca, Giorgia Chieppa, Fabrizia Tartaglione, Tommaso Colosimo, Cesare Pane, Marika Mercuri, Eugenio Medicina (Kaunas) Article Background and Objectives: The aim of this study was to evaluate longitudinal changes using both upper limb muscle Magnetic Resonance Imaging (MRI) at shoulder, arm and forearm levels and Performance of upper limb (PUL) in ambulant and non-ambulant Duchenne Muscular Dystrophy (DMD) patients. We also wished to define whether baseline muscle MRI could help to predict functional changes after one year. Materials and Methods: Twenty-seven patients had both baseline and 12month muscle MRI and PUL assessments one year later. Results: Ten were ambulant (age range 5–16 years), and 17 non ambulant (age range 10–30 years). Increased abnormalities equal or more than 1.5 point on muscle MRI at follow up were found on all domains: at shoulder level 12/27 patients (44%), at arm level 4/27 (15%) and at forearm level 6/27 (22%). Lower follow up PUL score were found in 8/27 patients (30%) at shoulder level, in 9/27 patients (33%) at mid-level whereas no functional changes were found at distal level. There was no constant association between baseline MRI scores and follow up PUL scores at arm and forearm levels but at shoulder level patients with moderate impairment on the baseline MRI scores between 16 and 34 had the highest risk of decreased function on PUL over a year. Conclusions: Our results confirmed that the integrated use of functional scales and imaging can help to monitor functional and MRI changes over time. MDPI 2021-11-18 /pmc/articles/PMC8624281/ /pubmed/34833484 http://dx.doi.org/10.3390/medicina57111267 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Brogna, Claudia
Cristiano, Lara
Verdolotti, Tommaso
Norcia, Giulia
Ficociello, Luana
Ruiz, Roberta
Coratti, Giorgia
Fanelli, Lavinia
Forcina, Nicola
Petracca, Giorgia
Chieppa, Fabrizia
Tartaglione, Tommaso
Colosimo, Cesare
Pane, Marika
Mercuri, Eugenio
Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy
title Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy
title_full Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy
title_fullStr Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy
title_full_unstemmed Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy
title_short Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy
title_sort longitudinal motor functional outcomes and magnetic resonance imaging patterns of muscle involvement in upper limbs in duchenne muscular dystrophy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624281/
https://www.ncbi.nlm.nih.gov/pubmed/34833484
http://dx.doi.org/10.3390/medicina57111267
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