Lentiviral Vectors Expressing Chimeric NEDD4 Ubiquitin Ligases: An Innovative Approach for Interfering with Alpha-Synuclein Accumulation

One of the main pathological features of Parkinson’s disease (PD) is a diffuse accumulation of alpha-synuclein (aS) aggregates in neurons. The NEDD4 E3 Ub ligase promotes aS degradation by the endosomal–lysosomal route. Interestingly, NEDD4, as well as being a small molecule able to trigger its func...

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Detalles Bibliográficos
Autores principales: Vogiatzis, Stefania, Celestino, Michele, Trevisan, Marta, Magro, Gloria, Del Vecchio, Claudia, Erdengiz, Deran, Palù, Giorgio, Parolin, Cristina, Maguire-Zeiss, Kathleen, Calistri, Arianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624294/
https://www.ncbi.nlm.nih.gov/pubmed/34831478
http://dx.doi.org/10.3390/cells10113256

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