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Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study

Alopecia areata is an autoimmune, inflammatory form of non-scarring hair loss that may affect any hair-bearing area. Recently, an increased risk of cardiovascular disorders has been described in patients with alopecia areata. The aim of the study was to evaluate the serum concentrations of proinflam...

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Autores principales: Waśkiel-Burnat, Anna, Niemczyk, Anna, Blicharz, Leszek, Chmielińska, Paulina, Zaremba, Michał, Gąsecka, Aleksandra, Filipiak, Krzysztof J., Olszewska, Małgorzata, Rudnicka, Lidia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624305/
https://www.ncbi.nlm.nih.gov/pubmed/34830700
http://dx.doi.org/10.3390/jcm10225418
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author Waśkiel-Burnat, Anna
Niemczyk, Anna
Blicharz, Leszek
Chmielińska, Paulina
Zaremba, Michał
Gąsecka, Aleksandra
Filipiak, Krzysztof J.
Olszewska, Małgorzata
Rudnicka, Lidia
author_facet Waśkiel-Burnat, Anna
Niemczyk, Anna
Blicharz, Leszek
Chmielińska, Paulina
Zaremba, Michał
Gąsecka, Aleksandra
Filipiak, Krzysztof J.
Olszewska, Małgorzata
Rudnicka, Lidia
author_sort Waśkiel-Burnat, Anna
collection PubMed
description Alopecia areata is an autoimmune, inflammatory form of non-scarring hair loss that may affect any hair-bearing area. Recently, an increased risk of cardiovascular disorders has been described in patients with alopecia areata. The aim of the study was to evaluate the serum concentrations of proinflammatory proteins associated with atherosclerosis (chemokine C-C motif ligand 4; CCL4, chemokine C-C motif ligand 7, CCL7; and sortilin, SORT1), and cardiovascular risk (myeloperoxidase, MPO; interleukin 1 receptor-like 1, IL1RL1; and growth differentiation factor 15, GDF15) in patients with alopecia areata without symptoms or prior cardiovascular disease in comparison with healthy controls. Sixty otherwise healthy patients with alopecia areata and twenty control subjects matched for age, gender, and body mass index (BMI) were enrolled in the study. No significant differences in the serum levels of MPO, IL1RL1, CCL4, CCL7, SORT1, and GDF15 were detected between patients with alopecia areata and healthy controls. A positive correlation was found between the serum concentration of CCL7 and the severity of alopecia areata (r = 0.281, p = 0.03), while GDF15 correlated with age at the disease onset (r = 0.509, p < 0.0001). The results of the present study suggest that the severity of alopecia areata may be associated with an increased risk of atherosclerosis.
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spelling pubmed-86243052021-11-27 Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study Waśkiel-Burnat, Anna Niemczyk, Anna Blicharz, Leszek Chmielińska, Paulina Zaremba, Michał Gąsecka, Aleksandra Filipiak, Krzysztof J. Olszewska, Małgorzata Rudnicka, Lidia J Clin Med Article Alopecia areata is an autoimmune, inflammatory form of non-scarring hair loss that may affect any hair-bearing area. Recently, an increased risk of cardiovascular disorders has been described in patients with alopecia areata. The aim of the study was to evaluate the serum concentrations of proinflammatory proteins associated with atherosclerosis (chemokine C-C motif ligand 4; CCL4, chemokine C-C motif ligand 7, CCL7; and sortilin, SORT1), and cardiovascular risk (myeloperoxidase, MPO; interleukin 1 receptor-like 1, IL1RL1; and growth differentiation factor 15, GDF15) in patients with alopecia areata without symptoms or prior cardiovascular disease in comparison with healthy controls. Sixty otherwise healthy patients with alopecia areata and twenty control subjects matched for age, gender, and body mass index (BMI) were enrolled in the study. No significant differences in the serum levels of MPO, IL1RL1, CCL4, CCL7, SORT1, and GDF15 were detected between patients with alopecia areata and healthy controls. A positive correlation was found between the serum concentration of CCL7 and the severity of alopecia areata (r = 0.281, p = 0.03), while GDF15 correlated with age at the disease onset (r = 0.509, p < 0.0001). The results of the present study suggest that the severity of alopecia areata may be associated with an increased risk of atherosclerosis. MDPI 2021-11-19 /pmc/articles/PMC8624305/ /pubmed/34830700 http://dx.doi.org/10.3390/jcm10225418 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Waśkiel-Burnat, Anna
Niemczyk, Anna
Blicharz, Leszek
Chmielińska, Paulina
Zaremba, Michał
Gąsecka, Aleksandra
Filipiak, Krzysztof J.
Olszewska, Małgorzata
Rudnicka, Lidia
Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study
title Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study
title_full Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study
title_fullStr Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study
title_full_unstemmed Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study
title_short Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study
title_sort chemokine c-c motif ligand 7 (ccl7), a biomarker of atherosclerosis, is associated with the severity of alopecia areata: a preliminary study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624305/
https://www.ncbi.nlm.nih.gov/pubmed/34830700
http://dx.doi.org/10.3390/jcm10225418
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