Cargando…
Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study
Alopecia areata is an autoimmune, inflammatory form of non-scarring hair loss that may affect any hair-bearing area. Recently, an increased risk of cardiovascular disorders has been described in patients with alopecia areata. The aim of the study was to evaluate the serum concentrations of proinflam...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624305/ https://www.ncbi.nlm.nih.gov/pubmed/34830700 http://dx.doi.org/10.3390/jcm10225418 |
_version_ | 1784606141364305920 |
---|---|
author | Waśkiel-Burnat, Anna Niemczyk, Anna Blicharz, Leszek Chmielińska, Paulina Zaremba, Michał Gąsecka, Aleksandra Filipiak, Krzysztof J. Olszewska, Małgorzata Rudnicka, Lidia |
author_facet | Waśkiel-Burnat, Anna Niemczyk, Anna Blicharz, Leszek Chmielińska, Paulina Zaremba, Michał Gąsecka, Aleksandra Filipiak, Krzysztof J. Olszewska, Małgorzata Rudnicka, Lidia |
author_sort | Waśkiel-Burnat, Anna |
collection | PubMed |
description | Alopecia areata is an autoimmune, inflammatory form of non-scarring hair loss that may affect any hair-bearing area. Recently, an increased risk of cardiovascular disorders has been described in patients with alopecia areata. The aim of the study was to evaluate the serum concentrations of proinflammatory proteins associated with atherosclerosis (chemokine C-C motif ligand 4; CCL4, chemokine C-C motif ligand 7, CCL7; and sortilin, SORT1), and cardiovascular risk (myeloperoxidase, MPO; interleukin 1 receptor-like 1, IL1RL1; and growth differentiation factor 15, GDF15) in patients with alopecia areata without symptoms or prior cardiovascular disease in comparison with healthy controls. Sixty otherwise healthy patients with alopecia areata and twenty control subjects matched for age, gender, and body mass index (BMI) were enrolled in the study. No significant differences in the serum levels of MPO, IL1RL1, CCL4, CCL7, SORT1, and GDF15 were detected between patients with alopecia areata and healthy controls. A positive correlation was found between the serum concentration of CCL7 and the severity of alopecia areata (r = 0.281, p = 0.03), while GDF15 correlated with age at the disease onset (r = 0.509, p < 0.0001). The results of the present study suggest that the severity of alopecia areata may be associated with an increased risk of atherosclerosis. |
format | Online Article Text |
id | pubmed-8624305 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86243052021-11-27 Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study Waśkiel-Burnat, Anna Niemczyk, Anna Blicharz, Leszek Chmielińska, Paulina Zaremba, Michał Gąsecka, Aleksandra Filipiak, Krzysztof J. Olszewska, Małgorzata Rudnicka, Lidia J Clin Med Article Alopecia areata is an autoimmune, inflammatory form of non-scarring hair loss that may affect any hair-bearing area. Recently, an increased risk of cardiovascular disorders has been described in patients with alopecia areata. The aim of the study was to evaluate the serum concentrations of proinflammatory proteins associated with atherosclerosis (chemokine C-C motif ligand 4; CCL4, chemokine C-C motif ligand 7, CCL7; and sortilin, SORT1), and cardiovascular risk (myeloperoxidase, MPO; interleukin 1 receptor-like 1, IL1RL1; and growth differentiation factor 15, GDF15) in patients with alopecia areata without symptoms or prior cardiovascular disease in comparison with healthy controls. Sixty otherwise healthy patients with alopecia areata and twenty control subjects matched for age, gender, and body mass index (BMI) were enrolled in the study. No significant differences in the serum levels of MPO, IL1RL1, CCL4, CCL7, SORT1, and GDF15 were detected between patients with alopecia areata and healthy controls. A positive correlation was found between the serum concentration of CCL7 and the severity of alopecia areata (r = 0.281, p = 0.03), while GDF15 correlated with age at the disease onset (r = 0.509, p < 0.0001). The results of the present study suggest that the severity of alopecia areata may be associated with an increased risk of atherosclerosis. MDPI 2021-11-19 /pmc/articles/PMC8624305/ /pubmed/34830700 http://dx.doi.org/10.3390/jcm10225418 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Waśkiel-Burnat, Anna Niemczyk, Anna Blicharz, Leszek Chmielińska, Paulina Zaremba, Michał Gąsecka, Aleksandra Filipiak, Krzysztof J. Olszewska, Małgorzata Rudnicka, Lidia Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study |
title | Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study |
title_full | Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study |
title_fullStr | Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study |
title_full_unstemmed | Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study |
title_short | Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study |
title_sort | chemokine c-c motif ligand 7 (ccl7), a biomarker of atherosclerosis, is associated with the severity of alopecia areata: a preliminary study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624305/ https://www.ncbi.nlm.nih.gov/pubmed/34830700 http://dx.doi.org/10.3390/jcm10225418 |
work_keys_str_mv | AT waskielburnatanna chemokineccmotifligand7ccl7abiomarkerofatherosclerosisisassociatedwiththeseverityofalopeciaareataapreliminarystudy AT niemczykanna chemokineccmotifligand7ccl7abiomarkerofatherosclerosisisassociatedwiththeseverityofalopeciaareataapreliminarystudy AT blicharzleszek chemokineccmotifligand7ccl7abiomarkerofatherosclerosisisassociatedwiththeseverityofalopeciaareataapreliminarystudy AT chmielinskapaulina chemokineccmotifligand7ccl7abiomarkerofatherosclerosisisassociatedwiththeseverityofalopeciaareataapreliminarystudy AT zarembamichał chemokineccmotifligand7ccl7abiomarkerofatherosclerosisisassociatedwiththeseverityofalopeciaareataapreliminarystudy AT gaseckaaleksandra chemokineccmotifligand7ccl7abiomarkerofatherosclerosisisassociatedwiththeseverityofalopeciaareataapreliminarystudy AT filipiakkrzysztofj chemokineccmotifligand7ccl7abiomarkerofatherosclerosisisassociatedwiththeseverityofalopeciaareataapreliminarystudy AT olszewskamałgorzata chemokineccmotifligand7ccl7abiomarkerofatherosclerosisisassociatedwiththeseverityofalopeciaareataapreliminarystudy AT rudnickalidia chemokineccmotifligand7ccl7abiomarkerofatherosclerosisisassociatedwiththeseverityofalopeciaareataapreliminarystudy |