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High Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients

Background: The aim of this study was to evaluate how the high sensitivity C-reactive protein (hs-CRP) values influence the risk of carotid plaque instability in association with other cardiovascular risk factors. Methods: One hundred and fifty-six carotid plaques from both symptomatic and asymptoma...

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Autores principales: Scimeca, Manuel, Montanaro, Manuela, Cardellini, Marina, Bonfiglio, Rita, Anemona, Lucia, Urbano, Nicoletta, Bonanno, Elena, Menghini, Rossella, Casagrande, Viviana, Martelli, Eugenio, Servadei, Francesca, Giacobbi, Erica, Ippoliti, Arnaldo, Bei, Roberto, Manzari, Vittorio, Federici, Massimo, Schillaci, Orazio, Mauriello, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624324/
https://www.ncbi.nlm.nih.gov/pubmed/34829465
http://dx.doi.org/10.3390/diagnostics11112117
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author Scimeca, Manuel
Montanaro, Manuela
Cardellini, Marina
Bonfiglio, Rita
Anemona, Lucia
Urbano, Nicoletta
Bonanno, Elena
Menghini, Rossella
Casagrande, Viviana
Martelli, Eugenio
Servadei, Francesca
Giacobbi, Erica
Ippoliti, Arnaldo
Bei, Roberto
Manzari, Vittorio
Federici, Massimo
Schillaci, Orazio
Mauriello, Alessandro
author_facet Scimeca, Manuel
Montanaro, Manuela
Cardellini, Marina
Bonfiglio, Rita
Anemona, Lucia
Urbano, Nicoletta
Bonanno, Elena
Menghini, Rossella
Casagrande, Viviana
Martelli, Eugenio
Servadei, Francesca
Giacobbi, Erica
Ippoliti, Arnaldo
Bei, Roberto
Manzari, Vittorio
Federici, Massimo
Schillaci, Orazio
Mauriello, Alessandro
author_sort Scimeca, Manuel
collection PubMed
description Background: The aim of this study was to evaluate how the high sensitivity C-reactive protein (hs-CRP) values influence the risk of carotid plaque instability in association with other cardiovascular risk factors. Methods: One hundred and fifty-six carotid plaques from both symptomatic and asymptomatic patients requiring surgical carotid endarterectomy were retrospectively collected. According to the modified American Heart Association, atherosclerosis plaques have been histologically distinguished into unstable and stable. The following anamnestic and hematochemical data were also considered: age, gender, hypertension, diabetes mellitus, smoking habit, therapy, low-density lipoprotein (LDL)-C, kidney failure and hs-CRP. Results: The results of our study clearly show that high levels of hs-CRP significantly increase the carotid plaque instability in dyslipidemic patients. Specifically, a 67% increase of the risk of carotid plaque instability was observed in patients with high LDL-C. Therefore, the highest risk was observed in male dyslipidemic patients 2333 (95% CI 0.73–7.48) and in aged female patients 2713 (95% CI 0.14–53.27). Discussion: These data strongly suggest a biological relationship between the hs-CRP values and the alteration of lipidic metabolism mostly in male patients affected by carotid atherosclerosis. The measurement of hs-CRP might be useful as a potential screening tool in the prevention of atheroscletotic disease.
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spelling pubmed-86243242021-11-27 High Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients Scimeca, Manuel Montanaro, Manuela Cardellini, Marina Bonfiglio, Rita Anemona, Lucia Urbano, Nicoletta Bonanno, Elena Menghini, Rossella Casagrande, Viviana Martelli, Eugenio Servadei, Francesca Giacobbi, Erica Ippoliti, Arnaldo Bei, Roberto Manzari, Vittorio Federici, Massimo Schillaci, Orazio Mauriello, Alessandro Diagnostics (Basel) Article Background: The aim of this study was to evaluate how the high sensitivity C-reactive protein (hs-CRP) values influence the risk of carotid plaque instability in association with other cardiovascular risk factors. Methods: One hundred and fifty-six carotid plaques from both symptomatic and asymptomatic patients requiring surgical carotid endarterectomy were retrospectively collected. According to the modified American Heart Association, atherosclerosis plaques have been histologically distinguished into unstable and stable. The following anamnestic and hematochemical data were also considered: age, gender, hypertension, diabetes mellitus, smoking habit, therapy, low-density lipoprotein (LDL)-C, kidney failure and hs-CRP. Results: The results of our study clearly show that high levels of hs-CRP significantly increase the carotid plaque instability in dyslipidemic patients. Specifically, a 67% increase of the risk of carotid plaque instability was observed in patients with high LDL-C. Therefore, the highest risk was observed in male dyslipidemic patients 2333 (95% CI 0.73–7.48) and in aged female patients 2713 (95% CI 0.14–53.27). Discussion: These data strongly suggest a biological relationship between the hs-CRP values and the alteration of lipidic metabolism mostly in male patients affected by carotid atherosclerosis. The measurement of hs-CRP might be useful as a potential screening tool in the prevention of atheroscletotic disease. MDPI 2021-11-15 /pmc/articles/PMC8624324/ /pubmed/34829465 http://dx.doi.org/10.3390/diagnostics11112117 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Scimeca, Manuel
Montanaro, Manuela
Cardellini, Marina
Bonfiglio, Rita
Anemona, Lucia
Urbano, Nicoletta
Bonanno, Elena
Menghini, Rossella
Casagrande, Viviana
Martelli, Eugenio
Servadei, Francesca
Giacobbi, Erica
Ippoliti, Arnaldo
Bei, Roberto
Manzari, Vittorio
Federici, Massimo
Schillaci, Orazio
Mauriello, Alessandro
High Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients
title High Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients
title_full High Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients
title_fullStr High Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients
title_full_unstemmed High Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients
title_short High Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients
title_sort high sensitivity c-reactive protein increases the risk of carotid plaque instability in male dyslipidemic patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624324/
https://www.ncbi.nlm.nih.gov/pubmed/34829465
http://dx.doi.org/10.3390/diagnostics11112117
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