A New Paradigm for KIM-PTP Drug Discovery: Identification of Allosteric Sites with Potential for Selective Inhibition Using Virtual Screening and LEI Analysis

The kinase interaction motif protein tyrosine phosphatases (KIM-PTPs), HePTP, PTPSL and STEP, are involved in the negative regulation of mitogen-activated protein kinase (MAPK) signalling pathways and are important therapeutic targets for a number of diseases. We have used VSpipe, a virtual screenin...

Descripción completa

Detalles Bibliográficos
Autores principales: Adams, James, Thornton, Benjamin P., Tabernero, Lydia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624330/
https://www.ncbi.nlm.nih.gov/pubmed/34830087
http://dx.doi.org/10.3390/ijms222212206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624330/
https://www.ncbi.nlm.nih.gov/pubmed/34830087
http://dx.doi.org/10.3390/ijms222212206

Ejemplares similares