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Is Primary HPV with Secondary p16/Ki67 Dual-Stain an Alternative HSIL-Risk Detection Strategy in Cervical Cancer Screening for Women under 30 Years?

Recently, cervical cancer rates elevation has been noted in women aged 20–39 years in regions with a very high human development index (HDI). The onset of cancer elevation rates is observed in the age range of 25–29 years, which should necessitate effective precancer screening in younger age groups,...

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Autores principales: Trzeszcz, Martyna, Mazurec, Maciej, Jach, Robert, Mazurec, Karolina, Jach, Zofia, Kotkowska-Szeps, Izabela, Kania, Magdalena, Wantuchowicz, Mariola, Prokopyk, Anna, Barcikowski, Piotr, Przybylski, Marcin, Wach, Joanna, Halon, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624363/
https://www.ncbi.nlm.nih.gov/pubmed/34829358
http://dx.doi.org/10.3390/diagnostics11112012
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author Trzeszcz, Martyna
Mazurec, Maciej
Jach, Robert
Mazurec, Karolina
Jach, Zofia
Kotkowska-Szeps, Izabela
Kania, Magdalena
Wantuchowicz, Mariola
Prokopyk, Anna
Barcikowski, Piotr
Przybylski, Marcin
Wach, Joanna
Halon, Agnieszka
author_facet Trzeszcz, Martyna
Mazurec, Maciej
Jach, Robert
Mazurec, Karolina
Jach, Zofia
Kotkowska-Szeps, Izabela
Kania, Magdalena
Wantuchowicz, Mariola
Prokopyk, Anna
Barcikowski, Piotr
Przybylski, Marcin
Wach, Joanna
Halon, Agnieszka
author_sort Trzeszcz, Martyna
collection PubMed
description Recently, cervical cancer rates elevation has been noted in women aged 20–39 years in regions with a very high human development index (HDI). The onset of cancer elevation rates is observed in the age range of 25–29 years, which should necessitate effective precancer screening in younger age groups, including those <25 years. From 30.066 liquid-based screening tests results (n = 30.066), 3849 liquid-based cytology, 1321 high-risk human papillomavirus (HRHPV) and 316 p16/Ki67 performed in women <30 years were selected. Performance characteristics were calculated for three screening models: primary HRHPV with p16/Ki67 triage, primary cytology with reflex HPV and primary cytology alone. Primary HRHPV with p16/Ki67 triage was significantly more sensitive in high-grade squamous intraepithelial lesion quantified with cervical intraepithelial neoplasia grade 2 or worse [HSIL(CIN2+)] detection than cytology with reflex HRHPV and cytology alone (83.3% vs. 70.8%/45.8%) and had significantly higher diagnostic predictive values (PPV:29.4%/21.3%/22.9%; NPV:91.7%/82.9%/82.2%, respectively at CIN2+ threshold). The number of colposcopies per HSIL(CIN2+) detection indices was 3.4, 4.7 and 4.4, respectively. Primary HPV testing in women <30 years with p16/Ki67 triage of HPV-positive cases might be an effective cervical cancer screening strategy for HSIL(CIN2+) detection with superior diagnostic performance when compared with primary cytology-based models. Women <25 years might also benefit from an introduction to a more sensitive screening approach.
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spelling pubmed-86243632021-11-27 Is Primary HPV with Secondary p16/Ki67 Dual-Stain an Alternative HSIL-Risk Detection Strategy in Cervical Cancer Screening for Women under 30 Years? Trzeszcz, Martyna Mazurec, Maciej Jach, Robert Mazurec, Karolina Jach, Zofia Kotkowska-Szeps, Izabela Kania, Magdalena Wantuchowicz, Mariola Prokopyk, Anna Barcikowski, Piotr Przybylski, Marcin Wach, Joanna Halon, Agnieszka Diagnostics (Basel) Article Recently, cervical cancer rates elevation has been noted in women aged 20–39 years in regions with a very high human development index (HDI). The onset of cancer elevation rates is observed in the age range of 25–29 years, which should necessitate effective precancer screening in younger age groups, including those <25 years. From 30.066 liquid-based screening tests results (n = 30.066), 3849 liquid-based cytology, 1321 high-risk human papillomavirus (HRHPV) and 316 p16/Ki67 performed in women <30 years were selected. Performance characteristics were calculated for three screening models: primary HRHPV with p16/Ki67 triage, primary cytology with reflex HPV and primary cytology alone. Primary HRHPV with p16/Ki67 triage was significantly more sensitive in high-grade squamous intraepithelial lesion quantified with cervical intraepithelial neoplasia grade 2 or worse [HSIL(CIN2+)] detection than cytology with reflex HRHPV and cytology alone (83.3% vs. 70.8%/45.8%) and had significantly higher diagnostic predictive values (PPV:29.4%/21.3%/22.9%; NPV:91.7%/82.9%/82.2%, respectively at CIN2+ threshold). The number of colposcopies per HSIL(CIN2+) detection indices was 3.4, 4.7 and 4.4, respectively. Primary HPV testing in women <30 years with p16/Ki67 triage of HPV-positive cases might be an effective cervical cancer screening strategy for HSIL(CIN2+) detection with superior diagnostic performance when compared with primary cytology-based models. Women <25 years might also benefit from an introduction to a more sensitive screening approach. MDPI 2021-10-29 /pmc/articles/PMC8624363/ /pubmed/34829358 http://dx.doi.org/10.3390/diagnostics11112012 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Trzeszcz, Martyna
Mazurec, Maciej
Jach, Robert
Mazurec, Karolina
Jach, Zofia
Kotkowska-Szeps, Izabela
Kania, Magdalena
Wantuchowicz, Mariola
Prokopyk, Anna
Barcikowski, Piotr
Przybylski, Marcin
Wach, Joanna
Halon, Agnieszka
Is Primary HPV with Secondary p16/Ki67 Dual-Stain an Alternative HSIL-Risk Detection Strategy in Cervical Cancer Screening for Women under 30 Years?
title Is Primary HPV with Secondary p16/Ki67 Dual-Stain an Alternative HSIL-Risk Detection Strategy in Cervical Cancer Screening for Women under 30 Years?
title_full Is Primary HPV with Secondary p16/Ki67 Dual-Stain an Alternative HSIL-Risk Detection Strategy in Cervical Cancer Screening for Women under 30 Years?
title_fullStr Is Primary HPV with Secondary p16/Ki67 Dual-Stain an Alternative HSIL-Risk Detection Strategy in Cervical Cancer Screening for Women under 30 Years?
title_full_unstemmed Is Primary HPV with Secondary p16/Ki67 Dual-Stain an Alternative HSIL-Risk Detection Strategy in Cervical Cancer Screening for Women under 30 Years?
title_short Is Primary HPV with Secondary p16/Ki67 Dual-Stain an Alternative HSIL-Risk Detection Strategy in Cervical Cancer Screening for Women under 30 Years?
title_sort is primary hpv with secondary p16/ki67 dual-stain an alternative hsil-risk detection strategy in cervical cancer screening for women under 30 years?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624363/
https://www.ncbi.nlm.nih.gov/pubmed/34829358
http://dx.doi.org/10.3390/diagnostics11112012
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