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LSD1: Expanding Functions in Stem Cells and Differentiation

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful model system to uncover fundamental mechanisms that control cellular identity during mammalian development. Histone methylation governs gene expression programs that play a key role in the regulation of the bala...

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Autores principales: Martinez-Gamero, Carlos, Malla, Sandhya, Aguilo, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624367/
https://www.ncbi.nlm.nih.gov/pubmed/34831474
http://dx.doi.org/10.3390/cells10113252
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author Martinez-Gamero, Carlos
Malla, Sandhya
Aguilo, Francesca
author_facet Martinez-Gamero, Carlos
Malla, Sandhya
Aguilo, Francesca
author_sort Martinez-Gamero, Carlos
collection PubMed
description Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful model system to uncover fundamental mechanisms that control cellular identity during mammalian development. Histone methylation governs gene expression programs that play a key role in the regulation of the balance between self-renewal and differentiation of ESCs. Lysine-specific demethylase 1 (LSD1, also known as KDM1A), the first identified histone lysine demethylase, demethylates H3K4me1/2 and H3K9me1/2 at target loci in a context-dependent manner. Moreover, it has also been shown to demethylate non-histone substrates playing a central role in the regulation of numerous cellular processes. In this review, we summarize current knowledge about LSD1 and the molecular mechanism by which LSD1 influences the stem cells state, including the regulatory circuitry underlying self-renewal and pluripotency.
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spelling pubmed-86243672021-11-27 LSD1: Expanding Functions in Stem Cells and Differentiation Martinez-Gamero, Carlos Malla, Sandhya Aguilo, Francesca Cells Review Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful model system to uncover fundamental mechanisms that control cellular identity during mammalian development. Histone methylation governs gene expression programs that play a key role in the regulation of the balance between self-renewal and differentiation of ESCs. Lysine-specific demethylase 1 (LSD1, also known as KDM1A), the first identified histone lysine demethylase, demethylates H3K4me1/2 and H3K9me1/2 at target loci in a context-dependent manner. Moreover, it has also been shown to demethylate non-histone substrates playing a central role in the regulation of numerous cellular processes. In this review, we summarize current knowledge about LSD1 and the molecular mechanism by which LSD1 influences the stem cells state, including the regulatory circuitry underlying self-renewal and pluripotency. MDPI 2021-11-20 /pmc/articles/PMC8624367/ /pubmed/34831474 http://dx.doi.org/10.3390/cells10113252 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martinez-Gamero, Carlos
Malla, Sandhya
Aguilo, Francesca
LSD1: Expanding Functions in Stem Cells and Differentiation
title LSD1: Expanding Functions in Stem Cells and Differentiation
title_full LSD1: Expanding Functions in Stem Cells and Differentiation
title_fullStr LSD1: Expanding Functions in Stem Cells and Differentiation
title_full_unstemmed LSD1: Expanding Functions in Stem Cells and Differentiation
title_short LSD1: Expanding Functions in Stem Cells and Differentiation
title_sort lsd1: expanding functions in stem cells and differentiation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624367/
https://www.ncbi.nlm.nih.gov/pubmed/34831474
http://dx.doi.org/10.3390/cells10113252
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