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LSD1: Expanding Functions in Stem Cells and Differentiation
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful model system to uncover fundamental mechanisms that control cellular identity during mammalian development. Histone methylation governs gene expression programs that play a key role in the regulation of the bala...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624367/ https://www.ncbi.nlm.nih.gov/pubmed/34831474 http://dx.doi.org/10.3390/cells10113252 |
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author | Martinez-Gamero, Carlos Malla, Sandhya Aguilo, Francesca |
author_facet | Martinez-Gamero, Carlos Malla, Sandhya Aguilo, Francesca |
author_sort | Martinez-Gamero, Carlos |
collection | PubMed |
description | Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful model system to uncover fundamental mechanisms that control cellular identity during mammalian development. Histone methylation governs gene expression programs that play a key role in the regulation of the balance between self-renewal and differentiation of ESCs. Lysine-specific demethylase 1 (LSD1, also known as KDM1A), the first identified histone lysine demethylase, demethylates H3K4me1/2 and H3K9me1/2 at target loci in a context-dependent manner. Moreover, it has also been shown to demethylate non-histone substrates playing a central role in the regulation of numerous cellular processes. In this review, we summarize current knowledge about LSD1 and the molecular mechanism by which LSD1 influences the stem cells state, including the regulatory circuitry underlying self-renewal and pluripotency. |
format | Online Article Text |
id | pubmed-8624367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86243672021-11-27 LSD1: Expanding Functions in Stem Cells and Differentiation Martinez-Gamero, Carlos Malla, Sandhya Aguilo, Francesca Cells Review Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful model system to uncover fundamental mechanisms that control cellular identity during mammalian development. Histone methylation governs gene expression programs that play a key role in the regulation of the balance between self-renewal and differentiation of ESCs. Lysine-specific demethylase 1 (LSD1, also known as KDM1A), the first identified histone lysine demethylase, demethylates H3K4me1/2 and H3K9me1/2 at target loci in a context-dependent manner. Moreover, it has also been shown to demethylate non-histone substrates playing a central role in the regulation of numerous cellular processes. In this review, we summarize current knowledge about LSD1 and the molecular mechanism by which LSD1 influences the stem cells state, including the regulatory circuitry underlying self-renewal and pluripotency. MDPI 2021-11-20 /pmc/articles/PMC8624367/ /pubmed/34831474 http://dx.doi.org/10.3390/cells10113252 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Martinez-Gamero, Carlos Malla, Sandhya Aguilo, Francesca LSD1: Expanding Functions in Stem Cells and Differentiation |
title | LSD1: Expanding Functions in Stem Cells and Differentiation |
title_full | LSD1: Expanding Functions in Stem Cells and Differentiation |
title_fullStr | LSD1: Expanding Functions in Stem Cells and Differentiation |
title_full_unstemmed | LSD1: Expanding Functions in Stem Cells and Differentiation |
title_short | LSD1: Expanding Functions in Stem Cells and Differentiation |
title_sort | lsd1: expanding functions in stem cells and differentiation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624367/ https://www.ncbi.nlm.nih.gov/pubmed/34831474 http://dx.doi.org/10.3390/cells10113252 |
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