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Association between Hepatic Steatosis and Obstructive Sleep Apnea in Children and Adolescents with Obesity
Background: Owing to the increasing rate of pediatric obesity, its complications such as non-alcoholic fatty liver disease (NAFLD) and obstructive sleep apnea (OSA) have become prevalent already in childhood. We aimed to assess the relationship between these two diseases in a cohort of children with...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624374/ https://www.ncbi.nlm.nih.gov/pubmed/34828697 http://dx.doi.org/10.3390/children8110984 |
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author | Carotenuto, Marco Di Sessa, Anna Esposito, Maria Grandone, Anna Marzuillo, Pierluigi Bitetti, Ilaria Umano, Giuseppina Rosaria Precenzano, Francesco Miraglia del Giudice, Emanuele Santoro, Nicola |
author_facet | Carotenuto, Marco Di Sessa, Anna Esposito, Maria Grandone, Anna Marzuillo, Pierluigi Bitetti, Ilaria Umano, Giuseppina Rosaria Precenzano, Francesco Miraglia del Giudice, Emanuele Santoro, Nicola |
author_sort | Carotenuto, Marco |
collection | PubMed |
description | Background: Owing to the increasing rate of pediatric obesity, its complications such as non-alcoholic fatty liver disease (NAFLD) and obstructive sleep apnea (OSA) have become prevalent already in childhood. We aimed to assess the relationship between these two diseases in a cohort of children with obesity. Methods: We enrolled 153 children with obesity (mean age 10.5 ± 2.66, mean BMI 30.9 ± 5.1) showing OSA. Subjects underwent a laboratory evaluation, a cardio-respiratory polysomnography (PSG), and a liver ultrasound. Results: All subjects had a clinical diagnosis of OSA based on the AHI > 1/h (mean AHI 8.0 ± 5.9; range 2.21–19.0). Of these, 69 showed hepatic steatosis (62.3% as mild, 20.3% as moderate, and 17.4% as severe degree). A strong association between ALT and apnea/hypopnea index (AHI) was observed (p = 0.0003). This association was not confirmed after adjusting for hepatic steatosis (p = 0.53). By subdividing our population according to the presence/absence of steatosis, this association was found only in the steatosis group (p = 0.009). As the severity of steatosis increased, the significance of its association with AHI compared to the absence of steatosis became progressively stronger (all p < 0.0001). Conclusions: Hepatic steatosis seems to drive the association between OSA and ALT levels, suggesting a potential pathogenic role of OSA in NAFLD. |
format | Online Article Text |
id | pubmed-8624374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86243742021-11-27 Association between Hepatic Steatosis and Obstructive Sleep Apnea in Children and Adolescents with Obesity Carotenuto, Marco Di Sessa, Anna Esposito, Maria Grandone, Anna Marzuillo, Pierluigi Bitetti, Ilaria Umano, Giuseppina Rosaria Precenzano, Francesco Miraglia del Giudice, Emanuele Santoro, Nicola Children (Basel) Article Background: Owing to the increasing rate of pediatric obesity, its complications such as non-alcoholic fatty liver disease (NAFLD) and obstructive sleep apnea (OSA) have become prevalent already in childhood. We aimed to assess the relationship between these two diseases in a cohort of children with obesity. Methods: We enrolled 153 children with obesity (mean age 10.5 ± 2.66, mean BMI 30.9 ± 5.1) showing OSA. Subjects underwent a laboratory evaluation, a cardio-respiratory polysomnography (PSG), and a liver ultrasound. Results: All subjects had a clinical diagnosis of OSA based on the AHI > 1/h (mean AHI 8.0 ± 5.9; range 2.21–19.0). Of these, 69 showed hepatic steatosis (62.3% as mild, 20.3% as moderate, and 17.4% as severe degree). A strong association between ALT and apnea/hypopnea index (AHI) was observed (p = 0.0003). This association was not confirmed after adjusting for hepatic steatosis (p = 0.53). By subdividing our population according to the presence/absence of steatosis, this association was found only in the steatosis group (p = 0.009). As the severity of steatosis increased, the significance of its association with AHI compared to the absence of steatosis became progressively stronger (all p < 0.0001). Conclusions: Hepatic steatosis seems to drive the association between OSA and ALT levels, suggesting a potential pathogenic role of OSA in NAFLD. MDPI 2021-11-01 /pmc/articles/PMC8624374/ /pubmed/34828697 http://dx.doi.org/10.3390/children8110984 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Carotenuto, Marco Di Sessa, Anna Esposito, Maria Grandone, Anna Marzuillo, Pierluigi Bitetti, Ilaria Umano, Giuseppina Rosaria Precenzano, Francesco Miraglia del Giudice, Emanuele Santoro, Nicola Association between Hepatic Steatosis and Obstructive Sleep Apnea in Children and Adolescents with Obesity |
title | Association between Hepatic Steatosis and Obstructive Sleep Apnea in Children and Adolescents with Obesity |
title_full | Association between Hepatic Steatosis and Obstructive Sleep Apnea in Children and Adolescents with Obesity |
title_fullStr | Association between Hepatic Steatosis and Obstructive Sleep Apnea in Children and Adolescents with Obesity |
title_full_unstemmed | Association between Hepatic Steatosis and Obstructive Sleep Apnea in Children and Adolescents with Obesity |
title_short | Association between Hepatic Steatosis and Obstructive Sleep Apnea in Children and Adolescents with Obesity |
title_sort | association between hepatic steatosis and obstructive sleep apnea in children and adolescents with obesity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624374/ https://www.ncbi.nlm.nih.gov/pubmed/34828697 http://dx.doi.org/10.3390/children8110984 |
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