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Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review

Background and objectives: Rosai–Dorfman disease (RDD) is a type of histiocytosis that usually appears in young adults or children as bilateral cervical lymphadenopathy, but extranodal involvement in not uncommon. Although the pathogenesis is not entirely elucidated, recent studies showed a possible...

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Autores principales: Iancu, George, Gica, Nicolae, Mustata, Laura Mihaela, Panaitescu, Anca Maria, Vasile, Danut, Peltecu, Gheorghe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624438/
https://www.ncbi.nlm.nih.gov/pubmed/34833385
http://dx.doi.org/10.3390/medicina57111167
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author Iancu, George
Gica, Nicolae
Mustata, Laura Mihaela
Panaitescu, Anca Maria
Vasile, Danut
Peltecu, Gheorghe
author_facet Iancu, George
Gica, Nicolae
Mustata, Laura Mihaela
Panaitescu, Anca Maria
Vasile, Danut
Peltecu, Gheorghe
author_sort Iancu, George
collection PubMed
description Background and objectives: Rosai–Dorfman disease (RDD) is a type of histiocytosis that usually appears in young adults or children as bilateral cervical lymphadenopathy, but extranodal involvement in not uncommon. Although the pathogenesis is not entirely elucidated, recent studies showed a possible neoplastic process. Materials and methods: Our manuscript presents a rare case of Rosai–Dorfman disease of the breast, the management of this rare case, and a literature review. There are few cases reported of RDD of the breast (around 90 globally reported cases); the data is poor, and the management not yet standardized for these cases. The case reported here shows the importance of correct breast investigation, breast imaging, and ultrasound-guided biopsy that provided an accurate diagnosis and guided further management. Results: Although RDD of the breast was rarely presented as bilateral disease in other case reports, our case showed bilateral breast disease with the suspicion of breast cancer on imaging. Pathology and immunohistochemistry were of critical importance and showed a specific pattern for histiocytosis. A multidisciplinary approach was taken into consideration for these cases in order to establish the approach. Some patients underwent surgery, but watchful waiting and close follow-up were the preferred approach. Conclusions: RDD of the breast is a rare form of histiocytosis, with fewer than 100 globally published cases. Although the management of this disease is not established yet by guidelines, a follow-up approach should be enough for these patients, and surgery might be overtreatment. Mortality from RDD is very low due to comorbidities. A multidisciplinary team decision is important, and abstinence might significantly benefit these patients.
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spelling pubmed-86244382021-11-27 Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review Iancu, George Gica, Nicolae Mustata, Laura Mihaela Panaitescu, Anca Maria Vasile, Danut Peltecu, Gheorghe Medicina (Kaunas) Case Report Background and objectives: Rosai–Dorfman disease (RDD) is a type of histiocytosis that usually appears in young adults or children as bilateral cervical lymphadenopathy, but extranodal involvement in not uncommon. Although the pathogenesis is not entirely elucidated, recent studies showed a possible neoplastic process. Materials and methods: Our manuscript presents a rare case of Rosai–Dorfman disease of the breast, the management of this rare case, and a literature review. There are few cases reported of RDD of the breast (around 90 globally reported cases); the data is poor, and the management not yet standardized for these cases. The case reported here shows the importance of correct breast investigation, breast imaging, and ultrasound-guided biopsy that provided an accurate diagnosis and guided further management. Results: Although RDD of the breast was rarely presented as bilateral disease in other case reports, our case showed bilateral breast disease with the suspicion of breast cancer on imaging. Pathology and immunohistochemistry were of critical importance and showed a specific pattern for histiocytosis. A multidisciplinary approach was taken into consideration for these cases in order to establish the approach. Some patients underwent surgery, but watchful waiting and close follow-up were the preferred approach. Conclusions: RDD of the breast is a rare form of histiocytosis, with fewer than 100 globally published cases. Although the management of this disease is not established yet by guidelines, a follow-up approach should be enough for these patients, and surgery might be overtreatment. Mortality from RDD is very low due to comorbidities. A multidisciplinary team decision is important, and abstinence might significantly benefit these patients. MDPI 2021-10-27 /pmc/articles/PMC8624438/ /pubmed/34833385 http://dx.doi.org/10.3390/medicina57111167 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Iancu, George
Gica, Nicolae
Mustata, Laura Mihaela
Panaitescu, Anca Maria
Vasile, Danut
Peltecu, Gheorghe
Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review
title Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review
title_full Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review
title_fullStr Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review
title_full_unstemmed Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review
title_short Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review
title_sort rosai–dorfman disease: breast involvement—case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624438/
https://www.ncbi.nlm.nih.gov/pubmed/34833385
http://dx.doi.org/10.3390/medicina57111167
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