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Alzheimer’s Disease-Related Metabolic Pattern in Diverse Forms of Neurodegenerative Diseases

Dementia is broadly characterized by cognitive and psychological dysfunction that significantly impairs daily functioning. Dementia has many causes including Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and frontotemporal lobar degeneration (FTLD). Detection and differential diagnosis...

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Autores principales: Lau, Angus, Beheshti, Iman, Modirrousta, Mandana, Kolesar, Tiffany A., Goertzen, Andrew L., Ko, Ji Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624480/
https://www.ncbi.nlm.nih.gov/pubmed/34829370
http://dx.doi.org/10.3390/diagnostics11112023
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author Lau, Angus
Beheshti, Iman
Modirrousta, Mandana
Kolesar, Tiffany A.
Goertzen, Andrew L.
Ko, Ji Hyun
author_facet Lau, Angus
Beheshti, Iman
Modirrousta, Mandana
Kolesar, Tiffany A.
Goertzen, Andrew L.
Ko, Ji Hyun
author_sort Lau, Angus
collection PubMed
description Dementia is broadly characterized by cognitive and psychological dysfunction that significantly impairs daily functioning. Dementia has many causes including Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and frontotemporal lobar degeneration (FTLD). Detection and differential diagnosis in the early stages of dementia remains challenging. Fueled by AD Neuroimaging Initiatives (ADNI) (Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. As such, the investigators within ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report.), a number of neuroimaging biomarkers for AD have been proposed, yet it remains to be seen whether these markers are also sensitive to other types of dementia. We assessed AD-related metabolic patterns in 27 patients with diverse forms of dementia (five had probable/possible AD while others had atypical cases) and 20 non-demented individuals. All participants had positron emission tomography (PET) scans on file. We used a pre-trained machine learning-based AD designation (MAD) framework to investigate the AD-related metabolic pattern among the participants under study. The MAD algorithm showed a sensitivity of 0.67 and specificity of 0.90 for distinguishing dementia patients from non-dementia participants. A total of 18/27 dementia patients and 2/20 non-dementia patients were identified as having AD-like patterns of metabolism. These results highlight that many underlying causes of dementia have similar hypometabolic pattern as AD and this similarity is an interesting avenue for future research.
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spelling pubmed-86244802021-11-27 Alzheimer’s Disease-Related Metabolic Pattern in Diverse Forms of Neurodegenerative Diseases Lau, Angus Beheshti, Iman Modirrousta, Mandana Kolesar, Tiffany A. Goertzen, Andrew L. Ko, Ji Hyun Diagnostics (Basel) Article Dementia is broadly characterized by cognitive and psychological dysfunction that significantly impairs daily functioning. Dementia has many causes including Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and frontotemporal lobar degeneration (FTLD). Detection and differential diagnosis in the early stages of dementia remains challenging. Fueled by AD Neuroimaging Initiatives (ADNI) (Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. As such, the investigators within ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report.), a number of neuroimaging biomarkers for AD have been proposed, yet it remains to be seen whether these markers are also sensitive to other types of dementia. We assessed AD-related metabolic patterns in 27 patients with diverse forms of dementia (five had probable/possible AD while others had atypical cases) and 20 non-demented individuals. All participants had positron emission tomography (PET) scans on file. We used a pre-trained machine learning-based AD designation (MAD) framework to investigate the AD-related metabolic pattern among the participants under study. The MAD algorithm showed a sensitivity of 0.67 and specificity of 0.90 for distinguishing dementia patients from non-dementia participants. A total of 18/27 dementia patients and 2/20 non-dementia patients were identified as having AD-like patterns of metabolism. These results highlight that many underlying causes of dementia have similar hypometabolic pattern as AD and this similarity is an interesting avenue for future research. MDPI 2021-11-01 /pmc/articles/PMC8624480/ /pubmed/34829370 http://dx.doi.org/10.3390/diagnostics11112023 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lau, Angus
Beheshti, Iman
Modirrousta, Mandana
Kolesar, Tiffany A.
Goertzen, Andrew L.
Ko, Ji Hyun
Alzheimer’s Disease-Related Metabolic Pattern in Diverse Forms of Neurodegenerative Diseases
title Alzheimer’s Disease-Related Metabolic Pattern in Diverse Forms of Neurodegenerative Diseases
title_full Alzheimer’s Disease-Related Metabolic Pattern in Diverse Forms of Neurodegenerative Diseases
title_fullStr Alzheimer’s Disease-Related Metabolic Pattern in Diverse Forms of Neurodegenerative Diseases
title_full_unstemmed Alzheimer’s Disease-Related Metabolic Pattern in Diverse Forms of Neurodegenerative Diseases
title_short Alzheimer’s Disease-Related Metabolic Pattern in Diverse Forms of Neurodegenerative Diseases
title_sort alzheimer’s disease-related metabolic pattern in diverse forms of neurodegenerative diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624480/
https://www.ncbi.nlm.nih.gov/pubmed/34829370
http://dx.doi.org/10.3390/diagnostics11112023
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